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PurM C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PurM C-terminal domain-like [ 56041]
Superfamily:   PurM C-terminal domain-like [ 56042]
Families:   PurM C-terminal domain-like [ 56043] (6)


Superfamily statistics
Genomes (2,916) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,839 67,761 16
Proteins 10,047 52,345 11


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000000001505 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000003715 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000005352 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000001736 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000000161 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.003637 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01669 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.00000000001919 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.0000000004696 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.00000001156 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.0000267 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0002944 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.4199 Moderately Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.000000002685 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000004701 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.1153 Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.000004214 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.001325 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.5667 Least Informative Inherited
Molecular Function (MF) binding 0.9629 Least Informative Inherited
Molecular Function (MF) protein binding 0.874 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.001564 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.02966 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.1358 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.004375 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00004458 Informative Direct
Molecular Function (MF) kinase activity 0.00005428 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.00006644 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.00006754 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001054 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0001212 Informative Direct
Molecular Function (MF) protein dimerization activity 0.002298 Informative Inherited
Molecular Function (MF) ATP binding 0.000004499 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000004672 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.01785 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001704 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2887 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.000001508 Informative Direct
Cellular Component (CC) nuclear membrane 0.000000008369 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.02445InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000000006207Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0.000000000001678Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)visible0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)cuticular specialization0InformativeDirect
Fly Anatomy (FA)wing vein0Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.8761Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.01263InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000000005018Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0.0000000000007116Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processThiamine biosynthesis0.0000000006781Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentVirion0.5713Moderately InformativeInherited
Coding sequence diversitySelenocysteine0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)thiamine metabolism0.00005041InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010918 SSF56042 Protein matches
Abstract

This entry includes Hydrogen expression/formation protein, HypE, which may be involved in the maturation of NifE hydrogenase; AIR synthase and FGAM synthase, which are involved in de novo purine biosynthesis; and selenide, water dikinase, an enzyme which synthesizes selenophosphate from selenide and ATP.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PurM C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PurM C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]