SUPERFAMILY 1.75 HMM library and genome assignments server

PurM C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PurM C-terminal domain-like [ 56041]
Superfamily:   PurM C-terminal domain-like [ 56042]
Families:   PurM C-terminal domain-like [ 56043] (6)


Superfamily statistics
Genomes (2,915) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,838 67,761 16
Proteins 10,048 52,345 11


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.00000000005305 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000005142 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000001583 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000004088 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000006107 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000172 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.02295 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000000001246 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000000004924 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000005574 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000121 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000159 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000194 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000002384 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000001112 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0001066 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.05711 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.05523 Moderately Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.000000000009118 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000005121 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00007872 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0003867 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.03909 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.3313 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.0000004883 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0000008562 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.00001987 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00002021 Highly Informative Direct
Molecular Function (MF) binding 0.4245 Least Informative Inherited
Molecular Function (MF) transferase activity 0.3156 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0005933 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1485 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.04964 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.001256 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000008685 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00001216 Informative Direct
Molecular Function (MF) nucleotide binding 0.0001151 Informative Direct
Molecular Function (MF) kinase activity 0.0002612 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0003529 Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000005038 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000716 Highly Informative Direct
Cellular Component (CC) membrane 0.8827 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7672 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.0003844 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.1089 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0000003947 Informative Direct
Cellular Component (CC) nuclear membrane 0.0000000009383 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.02445InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000000006207Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0.000000000001678Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)visible0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)cuticular specialization0InformativeDirect
Fly Anatomy (FA)wing vein0Highly InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.93Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.01635InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000000006082Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0.0000000000009478Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processThiamine biosynthesis0.0000000007337Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)thiamine metabolism0.00004838InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010918 SSF56042 Protein matches
Abstract

This entry includes Hydrogen expression/formation protein, HypE, which may be involved in the maturation of NifE hydrogenase; AIR synthase and FGAM synthase, which are involved in de novo purine biosynthesis; and selenide, water dikinase, an enzyme which synthesizes selenophosphate from selenide and ATP.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PurM C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PurM C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]