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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001416Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5783Least InformativeInherited
Disease Ontology (DO)genetic disease0.002693Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008689Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.04215Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07735Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1234Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1681Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002208InformativeDirect
Disease Ontology (DO)malignant glioma0.00000235InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008742InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001042InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008361InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9811InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004775Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.0000262Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008818Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.00028Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003038Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.0000001071InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09798Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1053Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1777Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00009834Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1243Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2177Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.327Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.005676InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.04664InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the stomach0.0002293Highly InformativeDirect
Phenotypic Abnormality (PA)Hemangioma0.0002735Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.006272Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.01433Highly InformativeInherited
Phenotypic Abnormality (PA)Urinary tract neoplasm0.2366Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002038Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001294Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002145Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03144Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9243Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000006774Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005029Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00008086Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002524Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.002968Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003857Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01609Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1949Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7303Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.0000241InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.03835InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08466InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.2131InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2476InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005031Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.000581Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007154Least InformativeDirect
Worm Phenotype (WP)larval lethal0.000944Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002169Least InformativeInherited
Worm Phenotype (WP)cell development variant0.003803Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01112Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01517Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.08727Least InformativeInherited
Worm Phenotype (WP)larval development variant0.1547Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.3023Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4599Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.4908Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000000002272Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00005289Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.00355Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.01487Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01607Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.08139Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.284Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.3456Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.3569Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.4496Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.9403Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.9498Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.972Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9798Moderately InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.9807Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.9837Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.9873Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.0000003525InformativeDirect
Worm Phenotype (WP)metal response variant0.000002555InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002965InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.000103InformativeDirect
Worm Phenotype (WP)life span variant0.0002044InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0002576InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.000285InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0004114InformativeDirect
Worm Phenotype (WP)protein modification variant0.0006551InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.00269InformativeInherited
Worm Phenotype (WP)nervous system physiology variant0.005196InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.007413InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.02694InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.05351InformativeInherited
Worm Phenotype (WP)egg laying variant0.07339InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.131InformativeInherited
Worm Phenotype (WP)chemical resistant0.1409InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1671InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1717InformativeInherited
Worm Phenotype (WP)vulva development variant0.2631InformativeInherited
Worm Phenotype (WP)drug resistant0.4666InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.5958InformativeInherited
Worm Phenotype (WP)odorant chemosensory response variant0.6208InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.6837InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.6949InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.703InformativeInherited
Worm Phenotype (WP)cell number increased0.9074InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9117InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000000001451Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000008619Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001549Highly InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.0000007575Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.00000165Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.00000679Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.00001717Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00002043Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.0000484Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00006701Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001388Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0003763Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0004919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0005872Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.0006088Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.003306Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.004823Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.009281Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.0157Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.06389Highly InformativeInherited
Worm Phenotype (WP)egg laying defective0.2689Highly InformativeInherited
Worm Phenotype (WP)postembryonic cell lineage variant0.2702Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8518Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9226Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.07311Least InformativeInherited
Fly Phenotype (FP)lethal0.8227Moderately InformativeInherited
Fly Phenotype (FP)size defective0.00000000008805InformativeDirect
Fly Phenotype (FP)wild-type0.0000001293InformativeDirect
Fly Phenotype (FP)cell number defective0.0000005272InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.000002156InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.000007621InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001265InformativeDirect
Fly Phenotype (FP)visible0.00002252InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001426InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0007292InformativeDirect
Fly Phenotype (FP)sterile0.0007862InformativeDirect
Fly Phenotype (FP)cell size defective0.000000002573Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.0000004677Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.00003559Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0001194Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0005052Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.0003596Least InformativeDirect
Fly Anatomy (FA)organism subdivision0.0003782Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0009518Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.002576Least InformativeInherited
Fly Anatomy (FA)adult0.01006Least InformativeInherited
Fly Anatomy (FA)larva0.01638Least InformativeInherited
Fly Anatomy (FA)cell0.06986Least InformativeInherited
Fly Anatomy (FA)embryo0.000000317Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0005325Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0.0008498Moderately InformativeDirect
Fly Anatomy (FA)gonad0.002522Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01285Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01797Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06052Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.1419Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.16Moderately InformativeInherited
Fly Anatomy (FA)cell component0.00002583InformativeDirect
Fly Anatomy (FA)imaginal disc0.0001091InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.000281InformativeDirect
Fly Anatomy (FA)gut section0.01743InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.1228InformativeInherited
Fly Anatomy (FA)epithelial tube0.4748InformativeInherited
Fly Anatomy (FA)egg0.0009285Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.002576Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.08056Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2178Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.6091InformativeInherited
Zebrafish Anatomy (ZA)integument0.3828Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1198Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2305Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.773Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00004699InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02119InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.0001217Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1475Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]