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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]

Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233

Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0002011Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5818Least InformativeInherited
Disease Ontology (DO)genetic disease0.002851Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008723Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.03835Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.08127Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1296Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1632Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002524InformativeDirect
Disease Ontology (DO)malignant glioma0.000002916InformativeDirect
Disease Ontology (DO)liver carcinoma0.00009549InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001041InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008086InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9809InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000005027Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00002868Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00009079Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0002894Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007545Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.000001256InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.08467Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.001103Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.331Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.009636InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the stomach0.08596Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006254Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002004Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001304Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002115Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03127Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9245Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.00000000682Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005051Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00007907Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002534Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003017Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003927Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.005708Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9539Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002505InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.03917InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08543InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.2152InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2441InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005107Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.0005605Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000002833Least InformativeDirect
Worm Phenotype (WP)larval lethal0.00001616Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001634Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.002215Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.01534Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01859Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03511Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4509Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6188Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00000000009106Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0000002646Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.0001416Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.002318Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.03837Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1257Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2808Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.3375Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.466Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.8438Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9375Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant1Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00000003997InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000004105InformativeDirect
Worm Phenotype (WP)positive chemotaxis variant0.00003345InformativeDirect
Worm Phenotype (WP)metal response variant0.00003773InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001308InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0004087InformativeDirect
Worm Phenotype (WP)protein modification variant0.003947InformativeInherited
Worm Phenotype (WP)oxygen response variant0.004163InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.01346InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.04526InformativeInherited
Worm Phenotype (WP)egg laying variant0.1264InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.1881InformativeInherited
Worm Phenotype (WP)vulva development variant0.2889InformativeInherited
Worm Phenotype (WP)drug resistant0.4026InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5628InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.5873InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.645InformativeInherited
Worm Phenotype (WP)VPC competence variant0.749InformativeInherited
Worm Phenotype (WP)cell number increased0.8235InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9102InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)endosome morphology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.00000000000009492Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000001306Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0000000009948Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001296Highly InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.0000004158Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0000007332Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.00000416Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0000325Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0000342Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00004846Highly InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.00007254Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001477Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0001898Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005663Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0006447Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.0007504Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.002119Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.007344Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01356Highly InformativeInherited
Worm Phenotype (WP)response to food variant0.02588Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.06496Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1278Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1744Highly InformativeInherited
Worm Phenotype (WP)egg retention0.422Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8521Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9322Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.139Least InformativeInherited
Fly Phenotype (FP)visible0.00001205Moderately InformativeDirect
Fly Phenotype (FP)lethal0.8198Moderately InformativeInherited
Fly Phenotype (FP)size defective0.0000000000004802InformativeDirect
Fly Phenotype (FP)wild-type0.0000001545InformativeDirect
Fly Phenotype (FP)cell number defective0.0000002519InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.000007985InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001394InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001599InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0004837InformativeDirect
Fly Phenotype (FP)sterile0.000868InformativeDirect
Fly Phenotype (FP)cell size defective0.00000006902Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.000002358Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0001325Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0005364Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0008602Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.001332Least InformativeInherited
Fly Anatomy (FA)larva0.002567Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.004842Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.005391Least InformativeInherited
Fly Anatomy (FA)adult0.07529Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3849Least InformativeInherited
Fly Anatomy (FA)gonad0.004433Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01115Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01578Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03488Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.09265Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1293Moderately InformativeInherited
Fly Anatomy (FA)cell component0.0005688InformativeDirect
Fly Anatomy (FA)epithelial cell0.0006434InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.0007002InformativeDirect
Fly Anatomy (FA)gut section0.01353InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.03058InformativeInherited
Fly Anatomy (FA)imaginal disc0.0002125Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.006158Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.002271Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.05439Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3373Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08826Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.08766InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1853InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1866InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.4725InformativeInherited
Zebrafish Anatomy (ZA)vein0.1125Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.3939Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4062Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1518Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2548Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7903Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00008202InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.002746InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.009626InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.00009176Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0005678Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1262Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]