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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001416Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5783Least InformativeInherited
Disease Ontology (DO)genetic disease0.002693Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008689Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.04215Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07735Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1234Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1681Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002208InformativeDirect
Disease Ontology (DO)malignant glioma0.00000235InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008742InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001042InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008361InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9811InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004775Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.0000262Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008818Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.00028Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0.0007505Moderately InformativeDirect
Mode of Inheritance (MI)Autosomal dominant inheritance0.0006476Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.0000003866InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1239Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.128Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0001037Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.09011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.3443Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.007229InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.3309InformativeInherited
Phenotypic Abnormality (PA)Hemangioma0.0002064Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the stomach0.0002234Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.006936Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006079Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002063Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001272Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002162Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03161Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.924Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000006818Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005045Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00008139Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002533Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.002966Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003852Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01608Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9547Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002503InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0384InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08466InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.213InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2483InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.0005812Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000003496Least InformativeDirect
Worm Phenotype (WP)larval lethal0.0006287Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001117Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.001643Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.00337Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.005624Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.005708Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01234Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.119Least InformativeInherited
Worm Phenotype (WP)larval development variant0.1739Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.3183Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3761Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000000004784Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.000000485Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00236Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01765Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.08421Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2718Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3302Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.3591Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4356Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.444Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.444Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.4468Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.4496Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.5125Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.5214Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6949Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.9907Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00000006471InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0000001063InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001098InformativeDirect
Worm Phenotype (WP)metal response variant0.00004208InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00006825InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001036InformativeDirect
Worm Phenotype (WP)life span variant0.0003391InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001342InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.003813InformativeInherited
Worm Phenotype (WP)oxygen response variant0.003863InformativeInherited
Worm Phenotype (WP)protein modification variant0.004452InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.004811InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.04374InformativeInherited
Worm Phenotype (WP)egg laying variant0.05318InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1473InformativeInherited
Worm Phenotype (WP)vulva development variant0.2824InformativeInherited
Worm Phenotype (WP)drug resistant0.4378InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5382InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.6286InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.6885InformativeInherited
Worm Phenotype (WP)cell number increased0.8367InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.8483InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9067InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.9519InformativeInherited
Worm Phenotype (WP)vesicle morphology variant1InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000008415Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.000000002579Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001863Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000001062Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.000006407Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00002591Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0000354Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00005387Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001364Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0005278Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005846Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0007294Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.002676Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.005188Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.006324Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.0137Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1247Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1717Highly InformativeInherited
Worm Phenotype (WP)egg laying defective0.4895Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8377Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9159Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1344Least InformativeInherited
Fly Phenotype (FP)lethal0.8296Moderately InformativeInherited
Fly Phenotype (FP)size defective0.0000000000008042InformativeDirect
Fly Phenotype (FP)wild-type0.0000001176InformativeDirect
Fly Phenotype (FP)cell number defective0.0000003528InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.0000112InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001198InformativeDirect
Fly Phenotype (FP)visible0.0000159InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001467InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0005083InformativeDirect
Fly Phenotype (FP)sterile0.0007923InformativeDirect
Fly Phenotype (FP)cell size defective0.00000001489Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.0000002555Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.00003149Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0001222Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0004649Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0006796Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.0006278Least InformativeDirect
Fly Anatomy (FA)nervous system0.001539Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.004308Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.005142Least InformativeInherited
Fly Anatomy (FA)adult0.06475Least InformativeInherited
Fly Anatomy (FA)somatic cell0.294Least InformativeInherited
Fly Anatomy (FA)portion of tissue0.00002453Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0009388Moderately InformativeDirect
Fly Anatomy (FA)gonad0.003859Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01119Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02061Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04362Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.1025Moderately InformativeInherited
Fly Anatomy (FA)cell component0.0002281InformativeDirect
Fly Anatomy (FA)ovariole0.0003971InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0005148InformativeDirect
Fly Anatomy (FA)epithelial cell0.0005518InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.0009373InformativeDirect
Fly Anatomy (FA)gut section0.01472InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.04071InformativeInherited
Fly Anatomy (FA)fat body0.1459InformativeInherited
Fly Anatomy (FA)epithelial tube0.65InformativeInherited
Fly Anatomy (FA)imaginal disc0.0002138Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.004766Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.001476Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.05145Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2403Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.06386Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.09803InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1892InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.228InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.5165InformativeInherited
Zebrafish Anatomy (ZA)vein0.1533Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.3955Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4613Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1249Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.22Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7567Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00004947InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.01158InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.000129Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1388Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]