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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001416Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5783Least InformativeInherited
Disease Ontology (DO)genetic disease0.002693Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008689Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.04215Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07735Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1234Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1681Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002208InformativeDirect
Disease Ontology (DO)malignant glioma0.00000235InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008742InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001042InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008361InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9811InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004775Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.0000262Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008818Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.00028Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0.0007505Moderately InformativeDirect
Mode of Inheritance (MI)Autosomal dominant inheritance0.0006476Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.0000003866InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1239Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.128Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0001037Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.09011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.3443Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.007229InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.3309InformativeInherited
Phenotypic Abnormality (PA)Hemangioma0.0002064Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the stomach0.0002234Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.006936Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006079Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002006Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001271Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002117Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03163Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.924Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000006818Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005045Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0000814Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002534Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003005Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003854Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01609Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9547Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002426InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0384InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08465InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.213InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2483InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.0005812Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000003721Least InformativeDirect
Worm Phenotype (WP)larval lethal0.0006133Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001124Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.001738Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.003333Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.005701Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.005787Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0129Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.117Least InformativeInherited
Worm Phenotype (WP)larval development variant0.1726Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.3164Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3824Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000000004981Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.0000004961Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.002244Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01781Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.08559Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2719Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3318Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.3593Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4322Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.4499Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.4499Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.4526Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.4551Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.5149Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.5184Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.696Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.9901Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.0000001106InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001131InformativeDirect
Worm Phenotype (WP)positive chemotaxis variant0.00003099InformativeDirect
Worm Phenotype (WP)metal response variant0.00004256InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00007031InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001058InformativeDirect
Worm Phenotype (WP)life span variant0.0003521InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001376InformativeInherited
Worm Phenotype (WP)oxygen response variant0.003892InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.003914InformativeInherited
Worm Phenotype (WP)protein modification variant0.00446InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.004818InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.04378InformativeInherited
Worm Phenotype (WP)egg laying variant0.05374InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1474InformativeInherited
Worm Phenotype (WP)vulva development variant0.2825InformativeInherited
Worm Phenotype (WP)drug resistant0.4381InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5398InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.6288InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.6959InformativeInherited
Worm Phenotype (WP)cell number increased0.8369InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.8454InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9084InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.952InformativeInherited
Worm Phenotype (WP)vesicle morphology variant1InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000008635Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.000000002587Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001905Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000001072Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.000006625Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00002598Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00003586Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00005402Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001367Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0005421Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005918Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0007311Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.0027Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.005246Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.006333Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01381Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1256Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.173Highly InformativeInherited
Worm Phenotype (WP)egg laying defective0.4929Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8378Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9161Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1229Least InformativeInherited
Fly Phenotype (FP)lethal0.8238Moderately InformativeInherited
Fly Phenotype (FP)size defective0.0000000000029InformativeDirect
Fly Phenotype (FP)wild-type0.0000001401InformativeDirect
Fly Phenotype (FP)cell number defective0.0000002091InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.00000199InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.000003867InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001419InformativeDirect
Fly Phenotype (FP)visible0.00003201InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000155InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0006951InformativeDirect
Fly Phenotype (FP)sterile0.0009844InformativeDirect
Fly Phenotype (FP)cell size defective0.000000008957Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.0000004669Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.00003354Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0001309Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0004982Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0008379Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.001309Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.003243Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.006489Least InformativeInherited
Fly Anatomy (FA)larva0.01575Least InformativeInherited
Fly Anatomy (FA)adult0.03099Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2924Least InformativeInherited
Fly Anatomy (FA)embryo0.000000003866Moderately InformativeDirect
Fly Anatomy (FA)gonad0.0044Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01488Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01605Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.05475Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.1349Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1981Moderately InformativeInherited
Fly Anatomy (FA)cell component0.00008828InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0002963InformativeDirect
Fly Anatomy (FA)ovariole0.0004361InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.0005772InformativeDirect
Fly Anatomy (FA)epithelial cell0.0007081InformativeDirect
Fly Anatomy (FA)gut section0.01752InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.03852InformativeInherited
Fly Anatomy (FA)fat body0.1807InformativeInherited
Fly Anatomy (FA)epithelial tube0.7185InformativeInherited
Fly Anatomy (FA)imaginal disc0.0001261Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.01034Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.04931Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.1097Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2404Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.06368Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.09849InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1894InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.229InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.5236InformativeInherited
Zebrafish Anatomy (ZA)scale0.00001321Highly InformativeDirect
Zebrafish Anatomy (ZA)vein0.1614Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4702Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.111Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2351Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7795Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00005404InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02058InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.000127Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1444Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]