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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001416Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5783Least InformativeInherited
Disease Ontology (DO)genetic disease0.002693Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008689Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.04215Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07735Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1234Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1681Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002208InformativeDirect
Disease Ontology (DO)malignant glioma0.00000235InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008742InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001042InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008361InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9811InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004775Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.0000262Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008818Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.00028Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0003063Least InformativeDirect
Mode of Inheritance (MI)Somatic mutation0.0000001077InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09733Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1047Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1785Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00009517Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1256Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.326Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.005732InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.04675InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the stomach0.0002293Highly InformativeDirect
Phenotypic Abnormality (PA)Hemangioma0.0002743Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.006266Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.01433Highly InformativeInherited
Phenotypic Abnormality (PA)Urinary tract neoplasm0.2366Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006079Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002006Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001271Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002117Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03163Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.924Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000006818Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005045Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0000814Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002534Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003005Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003854Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01609Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9547Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002426InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0384InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08465InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.213InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2483InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.0005812Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007433Least InformativeDirect
Worm Phenotype (WP)larval lethal0.0008662Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002296Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004009Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01148Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01221Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.08399Least InformativeInherited
Worm Phenotype (WP)larval development variant0.1483Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.2927Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.4582Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4601Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000000002756Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00006282Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.002536Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.01467Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01949Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.0814Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2863Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.347Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.3583Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.4524Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.9413Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.9625Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.9722Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.979Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9796Moderately InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.9809Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.9949Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.000000357InformativeDirect
Worm Phenotype (WP)metal response variant0.000002555InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002995InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001031InformativeDirect
Worm Phenotype (WP)life span variant0.0002394InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.0002851InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0004237InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0004523InformativeDirect
Worm Phenotype (WP)protein modification variant0.0006552InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.002642InformativeInherited
Worm Phenotype (WP)nervous system physiology variant0.005222InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.007346InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.02694InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.05353InformativeInherited
Worm Phenotype (WP)egg laying variant0.07345InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.1384InformativeInherited
Worm Phenotype (WP)chemical resistant0.141InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1665InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1717InformativeInherited
Worm Phenotype (WP)vulva development variant0.2604InformativeInherited
Worm Phenotype (WP)drug resistant0.4666InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.6018InformativeInherited
Worm Phenotype (WP)odorant chemosensory response variant0.6208InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.6836InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.6933InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.7029InformativeInherited
Worm Phenotype (WP)cell number increased0.9073InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.915InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000000001469Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000008684Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001991Highly InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.000000962Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000001744Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.000006947Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.00001728Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00002044Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.0000484Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00006724Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001388Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0003763Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0004804Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0005897Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.0006423Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.003313Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.004822Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.009336Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01574Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.06405Highly InformativeInherited
Worm Phenotype (WP)egg laying defective0.269Highly InformativeInherited
Worm Phenotype (WP)postembryonic cell lineage variant0.2702Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.852Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9224Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08671Least InformativeInherited
Fly Phenotype (FP)lethal0.8235Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0000001345InformativeDirect
Fly Phenotype (FP)cell number defective0.0000005456InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.000002002InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.000007331InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001319InformativeDirect
Fly Phenotype (FP)visible0.00002667InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001492InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0006734InformativeDirect
Fly Phenotype (FP)sterile0.000884InformativeDirect
Fly Phenotype (FP)size defective0.0000000003503Highly InformativeDirect
Fly Phenotype (FP)cell size defective0.000000008336Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.0000004999Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.00003212Highly InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0001309Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0005071Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.0009434Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.0003868Least InformativeDirect
Fly Anatomy (FA)nervous system0.0006157Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0009831Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.002866Least InformativeInherited
Fly Anatomy (FA)adult0.01309Least InformativeInherited
Fly Anatomy (FA)larva0.01854Least InformativeInherited
Fly Anatomy (FA)cell0.09933Least InformativeInherited
Fly Anatomy (FA)embryo0.0000001127Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.00009279Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0006122Moderately InformativeDirect
Fly Anatomy (FA)gonad0.002632Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01254Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01545Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.05867Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.129Moderately InformativeInherited
Fly Anatomy (FA)cell component0.00005862InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.0003773InformativeDirect
Fly Anatomy (FA)epithelial cell0.0006733InformativeDirect
Fly Anatomy (FA)gut section0.01695InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.03812InformativeInherited
Fly Anatomy (FA)epithelial tube0.7194InformativeInherited
Fly Anatomy (FA)imaginal disc0.0001151Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.01Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.08753Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.1022Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3333Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08238Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1685InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.2428InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.3149InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.5676InformativeInherited
Zebrafish Anatomy (ZA)vein0.1558Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.3837Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4632Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1197Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2318Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7745Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00004684InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02073InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.0001212Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.1474Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]