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Phoshoinositide 3-kinase (PI3K), catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Family:   Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]

Family statistics
Genomes (496) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,195 6,411 4
Proteins 2,191 6,400 4

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.000000000000009211Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.00000000000008231Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.03238Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5824Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0007943Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0009887Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.05741Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.1144Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.2488Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.003704InformativeInherited
Disease Ontology (DO)bile duct adenocarcinoma0.0005883Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1049Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2652Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.042Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.06606Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1258Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.1356InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00001415Highly InformativeDirect
Phenotypic Abnormality (PA)Breast carcinoma0.00006755Highly InformativeDirect
Phenotypic Abnormality (PA)Cafe-au-lait spot0.0002846Highly InformativeDirect
Phenotypic Abnormality (PA)Telangiectasia0.0003915Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000315Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.0003426Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000559Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0006728Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.001349Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001358Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.01707Least InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.0000005507Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.000005021Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.0000296Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.0001696Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0001872Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.0006123Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.001834Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.006275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.00755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.008114Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.008533Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.01029Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04178Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05497Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05521Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1897Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2629Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3777Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.5127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.0000009137InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.000004107InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.000004719InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.00002111InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.000228InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0003037InformativeDirect
Mammalian Phenotype (MP)premature death0.0003389InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0004826InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.0008344InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0.0008442InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.000991InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.001243InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.004002InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.01358InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.01442InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.06468InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1873InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen level0.00001849Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.00009316Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0002718Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0008752Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung size0.00139Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.1128Highly InformativeInherited
Mammalian Phenotype (MP)small liver0.274Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001548Least InformativeInherited
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.00001413Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.001645Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.001848Moderately InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0003196InformativeDirect
Worm Phenotype (WP)RNA expression variant0.04386InformativeInherited
Worm Phenotype (WP)mRNA levels increased0.00002086Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0.00001812Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.00003351InformativeDirect
Fly Phenotype (FP)cell death defective0.00007915InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.00000191Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)larva0.2384Least InformativeInherited
Fly Anatomy (FA)somatic cell0.723Least InformativeInherited
Fly Anatomy (FA)digestive system0.002405Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.05718Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.06433Moderately InformativeInherited
Fly Anatomy (FA)midgut0.000405InformativeDirect
Fly Anatomy (FA)somatic stem cell0.02073InformativeInherited
Fly Anatomy (FA)imaginal disc0.0261InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.02729InformativeInherited
Fly Anatomy (FA)epithelial tube0.08221InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.09306InformativeInherited
Fly Anatomy (FA)intestinal stem cell0.000001616Highly InformativeDirect
Fly Anatomy (FA)eye disc0.00005497Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.2282Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000000003816Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]