SUPERFAMILY 1.75 HMM library and genome assignments server

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Hect, E3 ligase catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Family:   Hect, E3 ligase catalytic domain [ 56205] (2)


Family statistics
Genomes (501) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,689 17,005 2
Proteins 5,665 16,937 2


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.001072Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.13Least InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle tone0.0006063Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.004325Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.03357Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.1238Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.5859Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7616Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.0004106InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0008161InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.09354InformativeInherited
Phenotypic Abnormality (PA)Wide mouth0.00009236Highly InformativeDirect
Phenotypic Abnormality (PA)Downturned corners of mouth0.0006455Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the eyebrow0.002504Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.04459Least InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.04293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2937Moderately InformativeInherited
Mammalian Phenotype (MP)decreased lean body mass0.00005955Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000008626Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001198Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0007137Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.04645Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.04645Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.000000007175Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0000001063Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000002992Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000006625Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.06374Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0.00000000000002735InformativeDirect
Worm Phenotype (WP)germ cell physiology variant0.0000626Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]