SUPERFAMILY 1.75 HMM library and genome assignments server


DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,244) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,154 36,058 17
Proteins 21,887 35,855 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process12.229e-06Least InformativeInherited
Biological Process (BP)single-organism cellular process0.28691Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.41990.5607Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0032630.6687Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0037270.7865Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0044860.5208Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0071920.829Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.011571Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.31430Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.049730Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.17780Moderately InformativeInherited
Biological Process (BP)DNA metabolic process3.675e-106.775e-10InformativeDirect
Biological Process (BP)cellular component disassembly2.398e-068.063e-07InformativeDirect
Biological Process (BP)dephosphorylation0.00090710InformativeDirect
Biological Process (BP)phospholipid metabolic process0.00095320InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.0041910InformativeInherited
Biological Process (BP)phosphatidylinositol metabolic process1.405e-050Highly InformativeDirect
Biological Process (BP)lipid modification0.00022740Highly InformativeDirect
Molecular Function (MF)hydrolase activity5.65e-080Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds2.587e-150Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.8191.031e-10InformativeInherited
Molecular Function (MF)nuclease activity3.444e-050.3932InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 2.229e-06 Least Informative Direct
Biological Process (BP) localization 0.6756 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5607 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6238 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9838 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7865 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.829 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5208 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6687 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.08748 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1399 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 9.377e-07 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 5.274e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002316 Moderately Informative Direct
Biological Process (BP) cellular localization 0.01828 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2889 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6883 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1698 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9297 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.186 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03563 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4876 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3027 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.125 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5774 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4437 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.01943 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2092 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2021 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.005788 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2715 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.0476 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1703 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2246 Moderately Informative Inherited
Biological Process (BP) system process 0.004452 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03473 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.003096 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.06835 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6798 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.005177 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1651 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6358 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001504 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7934 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 6.775e-10 Informative Direct
Biological Process (BP) cellular component disassembly 8.063e-07 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.561e-08 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001297 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 5.386e-05 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 2.738e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.515e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.011e-07 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.604e-05 Informative Direct
Biological Process (BP) positive regulation of transport 2.106e-05 Informative Direct
Biological Process (BP) regulation of intracellular transport 2.853e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.923e-05 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 4.801e-05 Informative Direct
Biological Process (BP) response to cytokine stimulus 6.937e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 7.398e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001126 Informative Direct
Biological Process (BP) regulation of reproductive process 0.000177 Informative Direct
Biological Process (BP) regulation of ion transport 0.0002015 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002446 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000263 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002887 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0002931 Informative Direct
Biological Process (BP) regulation of system process 0.0003011 Informative Direct
Biological Process (BP) response to organic nitrogen 0.0004438 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0008479 Informative Direct
Biological Process (BP) cellular membrane organization 0.0008486 Informative Direct
Biological Process (BP) regulation of protein localization 0.00167 Informative Inherited
Biological Process (BP) protein transport 0.0453 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.06023 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01008 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.08498 Informative Inherited
Biological Process (BP) regulation of response to stress 0.9584 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.06577 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1235 Informative Inherited
Biological Process (BP) growth 0.3894 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1418 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.03517 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02307 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6012 Informative Inherited
Biological Process (BP) response to external stimulus 0.978 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1905 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.03871 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.004177 Informative Inherited
Biological Process (BP) cell projection organization 0.0405 Informative Inherited
Biological Process (BP) synaptic transmission 0.00758 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04506 Informative Inherited
Biological Process (BP) regulation of cell development 0.1058 Informative Inherited
Biological Process (BP) generation of neurons 0.8387 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001269 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.4786 Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 4.1e-13 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 1.934e-11 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 4.696e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 4.986e-11 Highly Informative Direct
Biological Process (BP) RNA 3'-end processing 6.283e-11 Highly Informative Direct
Biological Process (BP) protein localization to membrane 5.863e-10 Highly Informative Direct
Biological Process (BP) negative regulation of reproductive process 1.452e-09 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.497e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 2.491e-09 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.921e-09 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 3.143e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 3.314e-09 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 6.77e-08 Highly Informative Direct
Biological Process (BP) synaptic vesicle transport 9.708e-08 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.922e-07 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 4.294e-07 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 7.795e-07 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 9.925e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.991e-06 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 2.668e-06 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 4.693e-06 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 1.602e-05 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.719e-05 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 5.275e-05 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0001742 Highly Informative Direct
Biological Process (BP) signal release 0.0002651 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0.000281 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.106 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.008346 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002109 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.002161 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.1342 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.2519 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.1585 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.2755 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.005143 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.003353 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.05268 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.7289 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.7666 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1.031e-10 Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity 7.829e-05 Informative Direct
Molecular Function (MF) DNA binding 0.004723 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.4909 Informative Inherited
Molecular Function (MF) nuclease activity 0.3932 Informative Inherited
Molecular Function (MF) receptor activity 0.2692 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3407 Informative Inherited
Molecular Function (MF) phospholipase activity 9.846e-11 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1.292e-07 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.0003556 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.09819 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.5514 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001233 Least Informative Inherited
Cellular Component (CC) membrane 0.3962 Least Informative Inherited
Cellular Component (CC) protein complex 0.5801 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2104 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 5.368e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.9793 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9034 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell projection part 2.753e-10 Informative Direct
Cellular Component (CC) cell leading edge 1.748e-08 Informative Direct
Cellular Component (CC) neuron part 2.943e-05 Informative Direct
Cellular Component (CC) nucleoplasm part 0.005771 Informative Inherited
Cellular Component (CC) CCR4-NOT complex 0 Highly Informative Direct
Cellular Component (CC) leading edge membrane 1.764e-12 Highly Informative Direct
Cellular Component (CC) nuclear body 4.238e-09 Highly Informative Direct
Cellular Component (CC) ruffle 7.702e-09 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 1.163e-08 Highly Informative Direct
Cellular Component (CC) cell projection membrane 2.014e-08 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 6.978e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases5.811e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase3.8e-10InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III8.279e-15Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest7.384e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1079Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1938Moderately InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to diet-induced obesity0.0007896Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant8.817e-05InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.1833Least InformativeInherited
Plant ANatomical entity (PAN)root epidermal cell0.002708InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007979Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2616Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001006Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001787Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6383Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases2.428e-05InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase3.436e-10Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters6.859e-05Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.2053Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis6.743e-15Moderately InformativeDirect
Biological processTranscription regulation1.721e-13Moderately InformativeDirect
Biological processDNA damage6.01e-11Moderately InformativeDirect
Biological processLipid metabolism2.323e-06Moderately InformativeDirect
Biological processEndocytosis9.088e-09InformativeDirect
Biological processCytolysis1.029e-06InformativeDirect
Biological processDNA recombination0.0005331InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processHemolysis1.604e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.1959Least InformativeInherited
Cellular componentEndoplasmic reticulum4.734e-11Moderately InformativeDirect
Cellular componentCell projection7.798e-10Moderately InformativeDirect
Cellular componentGolgi apparatus2.251e-06Moderately InformativeDirect
Cellular componentCytoskeleton0.0006669Moderately InformativeDirect
DomainRepeat5.102e-05Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding1.274e-15InformativeDirect
DomainSH2 domain2.863e-10InformativeDirect
Molecular functionMetal-binding5.561e-10Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding1.389e-08Moderately InformativeDirect
Molecular functionCalcium1.077e-06Moderately InformativeDirect
Molecular functionActin-binding1.604e-15InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator2.841e-12Moderately InformativeDirect
Post-translational modificationRepressor4.14e-09Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.3493Moderately InformativeInherited
Post-translational modificationExonuclease3.971e-14InformativeDirect
Post-translational modificationRNA-directed DNA polymerase4.826e-11Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000444Least InformativeDirect
Post-translational modificationS-nitrosylation6.584e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]