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DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,875) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,477 67,010 17
Proteins 26,123 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.000039370.01221Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000057930.1062Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.00075041Least InformativeInherited
Biological Process (BP)response to stimulus0.36060.02219Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.000060160.08714Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00014890.103Least InformativeInherited
Biological Process (BP)primary metabolic process0.011530.000007076Least InformativeInherited
Biological Process (BP)response to stress0.0064860.6742Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.1040.0555Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.22110.000003296Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.0000000000000059440.0000000000003081InformativeDirect
Biological Process (BP)cellular response to DNA damage stimulus0.00000010990.0000004883InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0042610.00000002442InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.0130.00000000006205InformativeInherited
Biological Process (BP)DNA catabolic process0.00016840.0009233Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000099910Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)nuclease activity0.000000000027380.002049InformativeInherited
Molecular Function (MF)deoxyribonuclease activity0.000000023920.00002255Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 0.000007076 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000005712 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.01221 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.949 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.103 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.08714 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02219 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02516 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1062 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.000003296 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.04563 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.02046 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2253 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.22 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6043 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9326 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4581 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03744 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3888 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04425 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.009601 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.09552 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.005326 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.03848 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.008645 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6006 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3026 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2168 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4174 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3384 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.6843 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0555 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.8978 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.2937 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5145 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01496 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.017 Moderately Informative Inherited
Biological Process (BP) response to stress 0.6742 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2793 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3205 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1649 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1031 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.05768 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0000000000003081 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0000004883 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000002442 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000000006205 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00000000158 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000002084 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000006027 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0000004166 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000954 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000006997 Informative Direct
Biological Process (BP) system process 0.00001636 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00004001 Informative Direct
Biological Process (BP) response to cytokine 0.00005594 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000873 Informative Direct
Biological Process (BP) protein targeting 0.0001231 Informative Direct
Biological Process (BP) regulation of system process 0.0002483 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002762 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0002769 Informative Direct
Biological Process (BP) negative regulation of transport 0.0003221 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000407 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.0005784 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.1093 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.01232 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.004778 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.006677 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.0236 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04252 Informative Inherited
Biological Process (BP) regulation of ion transport 0.00149 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.008128 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009282 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.008963 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.01419 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.4502 Informative Inherited
Biological Process (BP) cell development 0.4833 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7697 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9099 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01265 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.002858 Informative Inherited
Biological Process (BP) behavior 0.3049 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.01403 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.002209 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.08411 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8066 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.03922 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8545 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1175 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.002638 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.006065 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.04453 Informative Inherited
Biological Process (BP) DNA catabolic process 0.0009233 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.000000000000003692 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.00000000000001582 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.000000000005423 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.0000000001638 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000000003002 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000003797 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0.0000000007134 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.000000001456 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.000000001538 Highly Informative Direct
Biological Process (BP) negative regulation of cellular protein localization 0.0000000016 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000002169 Highly Informative Direct
Biological Process (BP) regulation of viral life cycle 0.000000002241 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.00000002248 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.00000002352 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000000029 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00000007826 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.000000268 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.0000002871 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000004101 Highly Informative Direct
Biological Process (BP) renal system process 0.0000004416 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0000005631 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.0000008326 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.00000114 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.000002837 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000002901 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00001855 Highly Informative Direct
Biological Process (BP) demethylation 0.00001876 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00001898 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.00002149 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00006666 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00007758 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00008058 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0001302 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0001304 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0001839 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0002019 Highly Informative Direct
Biological Process (BP) vesicle localization 0.0003014 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1246 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2755 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.05867 Highly Informative Inherited
Biological Process (BP) endocytosis 0.8437 Highly Informative Inherited
Biological Process (BP) cell division 0.02587 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.05392 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.2744 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02359 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1011 Highly Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.002139 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.9672 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.004104 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.08238 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1403 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.00006265 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.5016 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5796 Informative Inherited
Molecular Function (MF) signal transducer activity 0.6417 Informative Inherited
Molecular Function (MF) nuclease activity 0.002049 Informative Inherited
Molecular Function (MF) DNA binding 0.01208 Informative Inherited
Molecular Function (MF) deoxyribonuclease activity 0.00002255 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0000000000004336 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.00000001967 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0.0000105 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.2139 Highly Informative Inherited
Molecular Function (MF) chromatin binding 0.05561 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.08426 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001132 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1514 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6333 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002845 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell projection part 0.00000005475 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00002491 Informative Direct
Cellular Component (CC) organelle subcompartment 0.00002791 Informative Direct
Cellular Component (CC) plasma membrane region 0.00007547 Informative Direct
Cellular Component (CC) Golgi apparatus 0.003345 Informative Inherited
Cellular Component (CC) cis-Golgi network 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0 Highly Informative Direct
Cellular Component (CC) ruffle 0.000000000426 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000005811Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000038InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III0.000000000000008279Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.00007384Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.05377Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005717InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007667Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3597Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.0009079Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.006037Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6865Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00003076InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.0000000000283Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002166Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.3014Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000000000000006823Moderately InformativeDirect
Biological processApoptosis0.00000000000004407Moderately InformativeDirect
Biological processDNA damage0.000000000005455Moderately InformativeDirect
Biological processLipid metabolism0.0000007522Moderately InformativeDirect
Biological processImmunity0.0000009062Moderately InformativeDirect
Biological processEndocytosis0.000000001127InformativeDirect
Biological processmRNA processing0.000000008535InformativeDirect
Biological processCytolysis0.00000008535InformativeDirect
Biological processTranslation regulation0.000004636InformativeDirect
Biological processDNA recombination0.00003196InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00000000003769Highly InformativeDirect
Biological processHemolysis0.000000008213Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.1837Least InformativeInherited
Cellular componentEndoplasmic reticulum0.00000000003062Moderately InformativeDirect
Cellular componentCell projection0.0000000004472Moderately InformativeDirect
Cellular componentCytoskeleton0.0000002133Moderately InformativeDirect
Cellular componentGolgi apparatus0.00005073Moderately InformativeDirect
Cellular componentSecreted0.0006377Moderately InformativeDirect
DomainRepeat0.00008361Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding6.217e-16InformativeDirect
DomainSH2 domain0.0000000002234InformativeDirect
Molecular functionMetal-binding0.00000000004733Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0.00000001581Moderately InformativeDirect
Molecular functionCalcium0.00000006931Moderately InformativeDirect
Molecular functionActin-binding0.00000000000001957InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator0.00000000003075Moderately InformativeDirect
Post-translational modificationRepressor0.00000002829Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2858Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0.000000000001864Highly InformativeDirect
Post-translational modificationS-nitrosylation0.0000001543InformativeDirect
Post-translational modificationPrenylation0.0004612InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]