SUPERFAMILY 1.75 HMM library and genome assignments server


DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,873) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,015 67,010 17
Proteins 25,661 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.00023960.2614Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0003881Least InformativeInherited
Biological Process (BP)single-organism cellular process0.19470.7666Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.630.6937Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00065671Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00072210.37Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00025860.3341Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00048010.108Least InformativeInherited
Biological Process (BP)organic substance catabolic process2.193e-053.755e-15Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.1720Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.44280Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.36420Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00019650.002036Moderately InformativeInherited
Biological Process (BP)DNA metabolic process1.688e-159.148e-15InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.634e-053.788e-14InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process5.508e-100InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis6.159e-051.086e-14InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0012160InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0034640InformativeInherited
Biological Process (BP)dephosphorylation0.0083450InformativeInherited
Biological Process (BP)DNA catabolic process3.287e-120Highly InformativeDirect
Biological Process (BP)cellular component disassembly2.102e-063.41e-08Highly InformativeDirect
Biological Process (BP)lipid modification0.00026780Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process1.611e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity5.822e-090Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.93512.911e-09InformativeInherited
Molecular Function (MF)nuclease activity2.534e-060.09468InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0003881 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.6937 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7666 Least Informative Inherited
Biological Process (BP) localization 0.8769 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5931 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7744 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.37 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3341 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.108 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2614 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1173 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1067 Least Informative Inherited
Biological Process (BP) developmental process 0.7089 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 3.607e-05 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0006066 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 3.755e-15 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.4983 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4885 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01175 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3143 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1607 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005105 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002039 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4094 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5085 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6379 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7498 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7083 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0881 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001408 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1802 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05213 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.03114 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8094 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2019 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.002148 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1709 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5813 Moderately Informative Inherited
Biological Process (BP) system process 0.01426 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01394 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3008 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9811 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001238 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002036 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 9.148e-15 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.537e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005967 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003424 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.36e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0.0002045 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0001004 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001278 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.000682 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 3.788e-14 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0006435 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003359 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.92e-06 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 1.69e-12 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 6.567e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002916 Informative Direct
Biological Process (BP) negative regulation of transport 5.703e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.045e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.046e-10 Informative Direct
Biological Process (BP) organelle localization 0.0001698 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1.086e-14 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000613 Informative Direct
Biological Process (BP) regulation of system process 0.002065 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001282 Informative Inherited
Biological Process (BP) regulation of protein localization 0.003089 Informative Inherited
Biological Process (BP) protein transport 0.05807 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.07968 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01313 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01217 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.003123 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.08465 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.1539 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.02106 Informative Inherited
Biological Process (BP) growth 0.5438 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4293 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006804 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006405 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4344 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04293 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01171 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1484 Informative Inherited
Biological Process (BP) sexual reproduction 0.3224 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4826 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5324 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9368 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.466 Informative Inherited
Biological Process (BP) cell projection organization 0.05869 Informative Inherited
Biological Process (BP) RNA processing 0.06725 Informative Inherited
Biological Process (BP) synaptic transmission 0.006953 Informative Inherited
Biological Process (BP) secretion by cell 0.004653 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.04615 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1632 Informative Inherited
Biological Process (BP) regulation of cell development 0.2888 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01917 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.4016 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0003259 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 2.173e-10 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 1.325e-07 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0007705 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.009e-07 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 8.421e-09 Highly Informative Direct
Biological Process (BP) polyol metabolic process 3.178e-09 Highly Informative Direct
Biological Process (BP) cellular component disassembly 3.41e-08 Highly Informative Direct
Biological Process (BP) signal release 4.398e-06 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.341e-08 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 9.286e-07 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 3.272e-10 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 6.843e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 8.127e-07 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 2.284e-10 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 1.362e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.55e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 3.768e-05 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 1.599e-10 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.89e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.564e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 2.675e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.308e-08 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 3.943e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 7.507e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 5.154e-13 Highly Informative Direct
Biological Process (BP) cellular response to peptide 4.857e-05 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.01682 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.003887 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1047 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2323 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.005717 Highly Informative Inherited
Biological Process (BP) DNA modification 0.001814 Highly Informative Inherited
Biological Process (BP) cell division 0.02671 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2803 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.6398 Highly Informative Inherited
Biological Process (BP) exocytosis 0.005631 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.00732 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.01037 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01199 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.03504 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1464 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 2.911e-09 Informative Direct
Molecular Function (MF) DNA binding 0.01874 Informative Inherited
Molecular Function (MF) receptor activity 0.4722 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5399 Informative Inherited
Molecular Function (MF) nuclease activity 0.09468 Informative Inherited
Molecular Function (MF) manganese ion binding 8.49e-09 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 4.869e-07 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.001098 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.4775 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.004019 Least Informative Inherited
Cellular Component (CC) membrane 0.4967 Least Informative Inherited
Cellular Component (CC) protein complex 0.7645 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4052 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 5.901e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 2.534e-08 Informative Direct
Cellular Component (CC) nucleoplasm part 0.01272 Informative Inherited
Cellular Component (CC) trans-Golgi network 3.868e-08 Highly Informative Direct
Cellular Component (CC) nuclear body 1.032e-08 Highly Informative Direct
Cellular Component (CC) cell projection membrane 9.812e-08 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.345e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases5.811e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase3.8e-10InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III8.279e-15Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest7.384e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant8.817e-05InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3583Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001471Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.03137Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6642Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0002028InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase2.227e-11Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002332Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.3051Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation4.711e-16Moderately InformativeDirect
Biological processApoptosis1.384e-14Moderately InformativeDirect
Biological processDNA damage1.505e-11Moderately InformativeDirect
Biological processLipid metabolism3.289e-06Moderately InformativeDirect
Biological processEndocytosis1.33e-08InformativeDirect
Biological processCytolysis1.289e-06InformativeDirect
Biological processTranslation regulation2.242e-06InformativeDirect
Biological processDNA recombination4.628e-05InformativeDirect
Biological processCell adhesion0.0008951InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing9.095e-12Highly InformativeDirect
Biological processHemolysis1.937e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum2.209e-10Moderately InformativeDirect
Cellular componentCell projection7.343e-09Moderately InformativeDirect
Cellular componentGolgi apparatus4.923e-06Moderately InformativeDirect
DomainRepeat3.55e-05Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.217e-16InformativeDirect
DomainSH2 domain1.998e-10InformativeDirect
Molecular functionMetal-binding5.142e-13Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding1.496e-09Moderately InformativeDirect
Molecular functionCalcium2.702e-06Moderately InformativeDirect
Molecular functionActin-binding6.82e-15InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator4.654e-12Moderately InformativeDirect
Post-translational modificationRepressor7.548e-09Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2378Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase1.181e-12Highly InformativeDirect
Post-translational modificationS-nitrosylation3.702e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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