SUPERFAMILY 1.75 HMM library and genome assignments server


DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,872) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 26,014 67,010 17
Proteins 25,660 66,677 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.00023510.2431Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.000544Least InformativeInherited
Biological Process (BP)single-organism cellular process0.19290.8004Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.62460.8305Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.00067661Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0007110.3463Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00025580.3147Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00047470.09665Least InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process2.495e-051.72e-09Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.11750Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.43450Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.35550Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00018860.001735Moderately InformativeInherited
Biological Process (BP)DNA metabolic process1.683e-151.085e-14InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process1.368e-053.787e-14InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process5.645e-100InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis6.101e-051.085e-14InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0012160InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0035070InformativeInherited
Biological Process (BP)dephosphorylation0.0080950InformativeInherited
Biological Process (BP)DNA catabolic process3.736e-120Highly InformativeDirect
Biological Process (BP)cellular component disassembly2.12e-062.139e-06Highly InformativeDirect
Biological Process (BP)lipid modification0.00026720Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process1.608e-050Highly InformativeDirect
Molecular Function (MF)hydrolase activity5.786e-090Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.92651.87e-09InformativeInherited
Molecular Function (MF)nuclease activity2.8e-060.102InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000544 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.8305 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8004 Least Informative Inherited
Biological Process (BP) localization 0.9346 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6339 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6783 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3463 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3147 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.09665 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2431 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1181 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1139 Least Informative Inherited
Biological Process (BP) developmental process 0.7255 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0001639 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0005198 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.72e-09 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.936e-15 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.5044 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4917 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02043 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3144 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1514 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.009009 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4141 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.533 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6246 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.715 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6755 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.01112 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08159 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001238 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1703 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04905 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2661 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.0287 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.02623 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7782 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1782 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.00166 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1722 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0374 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8449 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2869 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9766 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001165 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001735 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) DNA metabolic process 1.085e-14 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.724e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005578 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003235 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.371e-05 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001985 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 9.615e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001245 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0006893 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 3.787e-14 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0006167 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003124 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.806e-06 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 3.098e-11 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 6.803e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002603 Informative Direct
Biological Process (BP) negative regulation of transport 5.23e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 8.954e-07 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.469e-10 Informative Direct
Biological Process (BP) organelle localization 0.0004534 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0003474 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1.085e-14 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0005589 Informative Direct
Biological Process (BP) regulation of system process 0.001795 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001268 Informative Inherited
Biological Process (BP) protein transport 0.058 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1256 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.03208 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01255 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002818 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09614 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.1734 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.0204 Informative Inherited
Biological Process (BP) growth 0.5336 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4103 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005797 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005445 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4707 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03962 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01184 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1466 Informative Inherited
Biological Process (BP) sexual reproduction 0.3161 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4781 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5347 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9377 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4573 Informative Inherited
Biological Process (BP) cell projection organization 0.05978 Informative Inherited
Biological Process (BP) RNA processing 0.06612 Informative Inherited
Biological Process (BP) secretion by cell 0.03621 Informative Inherited
Biological Process (BP) synaptic transmission 0.0171 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1627 Informative Inherited
Biological Process (BP) regulation of cell development 0.2766 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01702 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.3825 Informative Inherited
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 2.272e-10 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 8.623e-06 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0007276 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 4.964e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 8.898e-09 Highly Informative Direct
Biological Process (BP) polyol metabolic process 5.379e-09 Highly Informative Direct
Biological Process (BP) cellular component disassembly 2.139e-06 Highly Informative Direct
Biological Process (BP) signal release 0.0001753 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.096e-08 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 9.631e-07 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 2.912e-10 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 6.853e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 6.391e-07 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 6.689e-09 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 2.932e-10 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 1.242e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.333e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 3.348e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 6.154e-06 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.733e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.667e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.078e-08 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 3.492e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 6.602e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 2.762e-13 Highly Informative Direct
Biological Process (BP) cellular response to peptide 4.688e-05 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.02033 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.003786 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.104 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.221 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.006656 Highly Informative Inherited
Biological Process (BP) DNA modification 0.001837 Highly Informative Inherited
Biological Process (BP) cell division 0.02762 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2729 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.7009 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.00745 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.009739 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01153 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.03576 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1454 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1.87e-09 Informative Direct
Molecular Function (MF) DNA binding 0.01816 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.4529 Informative Inherited
Molecular Function (MF) receptor activity 0.4743 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5406 Informative Inherited
Molecular Function (MF) nuclease activity 0.102 Informative Inherited
Molecular Function (MF) manganese ion binding 5.858e-09 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 4.216e-07 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0.0011 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.4656 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.006155 Least Informative Inherited
Cellular Component (CC) membrane 0.6312 Least Informative Inherited
Cellular Component (CC) protein complex 0.8524 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4193 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 4.482e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.9992 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 2.405e-08 Informative Direct
Cellular Component (CC) nucleoplasm part 0.01278 Informative Inherited
Cellular Component (CC) trans-Golgi network 3.667e-08 Highly Informative Direct
Cellular Component (CC) nuclear body 1.114e-08 Highly Informative Direct
Cellular Component (CC) cell projection membrane 7.561e-08 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.459e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases5.811e-06Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase3.8e-10InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III8.279e-15Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest7.384e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.111Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05199Moderately InformativeInherited
Worm Phenotype (WP)locomotor coordination variant8.817e-05InformativeDirect
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000188Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0535Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005707InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3533Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001493Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0316Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6676Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000207InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase2.271e-11Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002367Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.3064Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation4.713e-16Moderately InformativeDirect
Biological processApoptosis1.382e-14Moderately InformativeDirect
Biological processDNA damage1.532e-11Moderately InformativeDirect
Biological processLipid metabolism3.334e-06Moderately InformativeDirect
Biological processEndocytosis1.261e-08InformativeDirect
Biological processCytolysis1.297e-06InformativeDirect
Biological processTranslation regulation2.227e-06InformativeDirect
Biological processDNA recombination4.663e-05InformativeDirect
Biological processCell adhesion0.0008912InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing9.172e-12Highly InformativeDirect
Biological processHemolysis1.95e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum1.935e-10Moderately InformativeDirect
Cellular componentCell projection6.844e-09Moderately InformativeDirect
Cellular componentGolgi apparatus4.74e-06Moderately InformativeDirect
DomainRepeat3.429e-05Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding9.229e-16InformativeDirect
DomainSH2 domain2.038e-10InformativeDirect
Molecular functionMetal-binding2.704e-13Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding1.45e-09Moderately InformativeDirect
Molecular functionCalcium2.34e-06Moderately InformativeDirect
Molecular functionActin-binding6.603e-15InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator4.66e-12Moderately InformativeDirect
Post-translational modificationRepressor6.406e-09Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2387Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationRNA-directed DNA polymerase1.19e-12Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0009896Least InformativeDirect
Post-translational modificationS-nitrosylation3.734e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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