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DNase I-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNase I-like [ 56218]
Superfamily:   DNase I-like [ 56219] (3)
Families:   DNase I-like [ 56220] (6)
  Inositol polyphosphate 5-phosphatase (IPP5) [ 64422] (2)
  Sphingomyelin phosphodiesterase-like [ 143902]


Superfamily statistics
Genomes (2,880) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 26,835 110,021 17
Proteins 26,478 109,211 17


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.000075190.0008414Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00024950.06048Least InformativeInherited
Biological Process (BP)response to stimulus0.28820.0206Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.000084970.03712Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.00090011Least InformativeInherited
Biological Process (BP)primary metabolic process0.020770.000005901Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000082390.04861Least InformativeInherited
Biological Process (BP)cellular response to stress0.0001030.00001321Moderately InformativeDirect
Biological Process (BP)DNA metabolic process0.000000000000011910.00000000000005114InformativeDirect
Biological Process (BP)cellular response to DNA damage stimulus0.00000035270.0000001093InformativeDirect
Molecular Function (MF)hydrolase activity0.00000002440Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds7.089e-160Moderately InformativeDirect
Molecular Function (MF)nuclease activity0.000000000037480.005358InformativeInherited
Molecular Function (MF)deoxyribonuclease activity0.000000018340.000008111Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.0008414 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000005901 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000007708 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002813 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.06048 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.04861 Least Informative Inherited
Biological Process (BP) response to stimulus 0.0206 Least Informative Inherited
Biological Process (BP) biological regulation 0.6534 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.03712 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.00001321 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000001608 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00005625 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.8194 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03745 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.0859 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.06487 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001919 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.03018 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4759 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.05841 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.008538 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7023 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.708 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3542 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9695 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.006666 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6984 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.2161 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1344 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6151 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6257 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06968 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9031 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.4883 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2397 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.246 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.06255 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3181 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03493 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02986 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3883 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2122 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.493 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.00000000000005114 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0000001093 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000004618 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000000000008963 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000000001542 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000000002637 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000009139 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000003108 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000003867 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000004485 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.00001495 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.00003224 Informative Direct
Biological Process (BP) membrane organization 0.00005797 Informative Direct
Biological Process (BP) response to cytokine 0.0001709 Informative Direct
Biological Process (BP) regulation of system process 0.0002975 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0004115 Informative Direct
Biological Process (BP) positive regulation of transport 0.0004831 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.0005648 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0007116 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0007258 Informative Direct
Biological Process (BP) organelle localization 0.0007895 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.1472 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.006997 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01035 Informative Inherited
Biological Process (BP) cell development 0.5661 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.8799 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0557 Informative Inherited
Biological Process (BP) intracellular protein transport 0.2836 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0229 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001771 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.06506 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01391 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.02298 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.7158 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8309 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.03064 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.07191 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.00523 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.01641 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.01473 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02703 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.09503 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.01027 Informative Inherited
Biological Process (BP) regulation of ion transport 0.00164 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9418 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.05848 Informative Inherited
Biological Process (BP) system process 0.003563 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.008351 Informative Inherited
Biological Process (BP) cellular lipid catabolic process 0.8976 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.7649 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.04792 Informative Inherited
Biological Process (BP) behavior 0.3191 Informative Inherited
Biological Process (BP) RNA catabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.00000000006966 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.0000000001139 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.0000000004211 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000006788 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.000000002068 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000000003957 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000004052 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000000004583 Highly Informative Direct
Biological Process (BP) renal system process 0.00000000562 Highly Informative Direct
Biological Process (BP) regulation of viral process 0.000000007899 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000001078 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0000000214 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000000295 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.00000003091 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000005524 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00000006345 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0000008286 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.000001359 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.000001433 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.000001966 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.000002158 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000374 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00000535 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.000007598 Highly Informative Direct
Biological Process (BP) demethylation 0.00002216 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00002328 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00002527 Highly Informative Direct
Biological Process (BP) vesicle localization 0.00003497 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000618 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00009576 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0001613 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0001842 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0002004 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0003472 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1529 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2901 Highly Informative Inherited
Biological Process (BP) cell division 0.04099 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.07881 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02663 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.02501 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.01458 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.007358 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.0949 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2701 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0.8929 Informative Inherited
Molecular Function (MF) nuclease activity 0.005358 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.6059 Informative Inherited
Molecular Function (MF) signal transducer activity 0.6912 Informative Inherited
Molecular Function (MF) DNA binding 0.03197 Informative Inherited
Molecular Function (MF) deoxyribonuclease activity 0.000008111 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.00000000000003473 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.00000004007 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0.000007747 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.06865 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.1123 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.1442 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0006178 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2625 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0005718 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.00002217 Informative Direct
Cellular Component (CC) nucleoplasm part 0.0001263 Informative Direct
Cellular Component (CC) plasma membrane region 0.0001344 Informative Direct
Cellular Component (CC) Golgi apparatus 0.004392 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0 Highly Informative Direct
Cellular Component (CC) cis-Golgi network 0 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000000005751 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.000001929 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00002295 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.2093Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.6315Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000005811Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004367Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000038InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonuclease III0.000000000000008279Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.00007384Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0.007261Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.0006305InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.05377Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.005717InformativeInherited
Plant ANatomical entity (PAN)root hair cell0.0007667Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.369Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.0008293Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.006258Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.673Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00003588InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000002593Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.0002113Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.2989Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000000000000008004Moderately InformativeDirect
Biological processApoptosis0.00000000000004505Moderately InformativeDirect
Biological processDNA damage0.00000000000552Moderately InformativeDirect
Biological processLipid metabolism0.0000007411Moderately InformativeDirect
Biological processImmunity0.000001039Moderately InformativeDirect
Biological processEndocytosis0.000000001164InformativeDirect
Biological processmRNA processing0.000000009139InformativeDirect
Biological processCytolysis0.0000000944InformativeDirect
Biological processTranslation regulation0.000005134InformativeDirect
Biological processDNA recombination0.00003152InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00000000004235Highly InformativeDirect
Biological processHemolysis0.000000008863Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.1872Least InformativeInherited
Cellular componentEndoplasmic reticulum0.00000000004145Moderately InformativeDirect
Cellular componentCell projection0.0000000009902Moderately InformativeDirect
Cellular componentCytoskeleton0.0000002595Moderately InformativeDirect
Cellular componentGolgi apparatus0.00005261Moderately InformativeDirect
Cellular componentSecreted0.0006449Moderately InformativeDirect
DomainRepeat0.00009255Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH3-binding6.234e-16InformativeDirect
DomainSH2 domain0.0000000002271InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0.00000000006637Least InformativeDirect
Molecular functionCalcium0.0000000755Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationActivator0.00000000001225Moderately InformativeDirect
Post-translational modificationRepressor0.00000001268Moderately InformativeDirect
Post-translational modificationRNA-binding0.00000002222Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.2818Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationActin-binding0.00000000000002388InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0.000000000001783Highly InformativeDirect
Post-translational modificationS-nitrosylation0.0000001563InformativeDirect
Post-translational modificationPrenylation0.000457InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR005135 SSF56219 Protein matches
Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [PubMed10838565]. Proteins this domain is found in include: AP endonuclease proteins , DNase I proteins , Synaptojanin an inositol-1,4,5-trisphosphate phosphatase and Sphingomyelinase .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNase I-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the DNase I-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]