SUPERFAMILY 1.75 HMM library and genome assignments server

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Proteasome subunits family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Family:   Proteasome subunits [ 56251] (3)


Family statistics
Genomes (2,389) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,760 44,424 67
Proteins 11,746 44,363 67


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of body weight0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal homeostasis0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal inflammatory response0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Flexion contracture0InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0InformativeDirect
Phenotypic Abnormality (PA)Anemia0InformativeDirect
Phenotypic Abnormality (PA)Fever0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0InformativeDirect
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet count0InformativeDirect
Phenotypic Abnormality (PA)Pain0InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0InformativeDirect
Phenotypic Abnormality (PA)Abnormal liver morphology0InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0Highly InformativeDirect
Phenotypic Abnormality (PA)Skin rash0Highly InformativeDirect
Phenotypic Abnormality (PA)Failure to thrive0Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent fever0Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatomegaly0Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0Highly InformativeDirect
Phenotypic Abnormality (PA)Increased antibody level in blood0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.33Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.00003462InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000005537Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00000265Least InformativeDirect
Worm Phenotype (WP)cell division variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000008441Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0000001639Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000007821Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.0007243Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0008997Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.1309Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.3698Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5259Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.5926Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.000000000000003117InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000000000000006229InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.000000009182InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00001337InformativeDirect
Worm Phenotype (WP)cell component localization variant0.001971InformativeInherited
Worm Phenotype (WP)mitosis variant0.01154InformativeInherited
Worm Phenotype (WP)gonad development variant0.02277InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03367InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2264InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.3615InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.3972InformativeInherited
Worm Phenotype (WP)rachis narrow0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0Highly InformativeDirect
Worm Phenotype (WP)cell cycle arrest0.00000000000401Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000000000006223Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.0000000003545Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.000000001986Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000005678Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.000002656Highly InformativeDirect
Worm Phenotype (WP)molt variant0.00004827Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.00006191Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0007988Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.0008106Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.001174Moderately InformativeInherited
Yeast Phenotype (YP)heat sensitivity0.0000005238InformativeDirect
Yeast Phenotype (YP)killer toxin resistance0.0000001011Highly InformativeDirect
Yeast Phenotype (YP)colony sectoring0.00000256Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.02913Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0009885Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0.000004045InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.000007193InformativeDirect
Xenopus ANatomical entity (XAN)muscle0.00001859InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0.00007701InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008948InformativeDirect
Xenopus ANatomical entity (XAN)limb0.000132InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.002639InformativeInherited
Xenopus ANatomical entity (XAN)thymus0.000002492Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660.0000006687InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.000000000006435InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]