SUPERFAMILY 1.75 HMM library and genome assignments server

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SMAD MH1 domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SMAD MH1 domain [ 56365]
Superfamily:   SMAD MH1 domain [ 56366]
Family:   SMAD MH1 domain [ 56367]


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 912 2,712 2
Proteins 910 2,706 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01347Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03912Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.0000019InformativeDirect
Disease Ontology (DO)scleroderma0.0001326InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.008326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.0542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.05623Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0006906InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.00289InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.004245InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.02075InformativeInherited
Phenotypic Abnormality (PA)Aortic dissection0.0000002401Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.00003133Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0002311Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.004735Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.008765Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.0092Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02339Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000001511Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.000006926Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00002059Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.00002984Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0000591Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001252Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.000728Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.009354Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1177Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.000001092InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.000002101InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00002687InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0002259InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.000527InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.001005InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.009131InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.04125InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.1759InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.2758InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.307InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8189InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.0000000186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.0000003112Highly InformativeDirect
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.00000258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.000003416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.000007691Highly InformativeDirect
Mammalian Phenotype (MP)abnormal chorioallantoic fusion0.00001314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.00002984Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.0000358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.00003974Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0005148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0005668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system development0.0006262Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.001563Highly InformativeInherited
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.01125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.04988Highly InformativeInherited
Mammalian Phenotype (MP)abnormal female germ cell morphology0.05192Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0004937Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0001097Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0006569Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0006669Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.005358Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.0135Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.04886Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3779Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000003277InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000002146InformativeDirect
Worm Phenotype (WP)male morphology variant0.000008156InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.000011InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.00001516InformativeDirect
Worm Phenotype (WP)head movement variant0.00001726InformativeDirect
Worm Phenotype (WP)fat content variant0.00001875InformativeDirect
Worm Phenotype (WP)body posture variant0.002129InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.008659InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.009278InformativeInherited
Worm Phenotype (WP)small0.08674InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)short0.000002707Highly InformativeDirect
Worm Phenotype (WP)sexually dimorphic development variant0.000004152Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.000004268Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.000004959Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.000008802Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000009029Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.000009975Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant0.00001208Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00001801Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.00002082Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.00003472Highly InformativeDirect
Worm Phenotype (WP)tail morphology variant0.001184Highly InformativeInherited
Worm Phenotype (WP)male ray morphology variant0.0396Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)size defective0InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)cell number defective0InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)abdomen0Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0Moderately InformativeDirect
Fly Anatomy (FA)larval segment0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult external thorax0Moderately InformativeDirect
Fly Anatomy (FA)digestive system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.00637Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.008879Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01814Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.07825Moderately InformativeInherited
Fly Anatomy (FA)larval thoracic segment0InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)cuticular specialization0InformativeDirect
Fly Anatomy (FA)synaptic neuropil domain0.0005571InformativeDirect
Fly Anatomy (FA)egg0.0007083InformativeDirect
Fly Anatomy (FA)ovariole0.0068InformativeInherited
Fly Anatomy (FA)cell component0.008177InformativeInherited
Fly Anatomy (FA)germline cell0.01698InformativeInherited
Fly Anatomy (FA)larval mesothoracic segment0Highly InformativeDirect
Fly Anatomy (FA)dorsal thoracic disc0Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.000002485Highly InformativeDirect
Fly Anatomy (FA)bouton0.0004912Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.05224Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.09787Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.0001293InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.01071InformativeInherited
Zebrafish Anatomy (ZA)immune system0.01546InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.08996InformativeInherited
Zebrafish Anatomy (ZA)floor plate0.00000001662Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.000007539Highly InformativeDirect
Zebrafish Anatomy (ZA)mononuclear phagocyte0.00007818Highly InformativeDirect
Zebrafish Anatomy (ZA)professional antigen presenting cell0.0000985Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.1086Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail region0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004973Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.1373Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.000001682InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0002023InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0002498InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0003824InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0004608InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0006252InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0006773InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.04043InformativeInherited
Xenopus ANatomical entity (XAN)ciliated cell0.0000007316Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00001085Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD MH1 domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]