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C-type lectin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Families:   C-type lectin domain [ 56437] (28)
  Aerolysin/Pertussis toxin (APT) domain [ 56467] (2)
  Invasin/intimin cell-adhesion fragment, C-terminal domain [ 56472] (2)
  Link domain [ 56477] (2)
  Endostatin [ 56480] (2)
  Noncollagenous (NC1) domain of collagen IV [ 75585]
  Sulfatase-modifying factor-like [ 143959] (2)
  Mtd variable domain [ 143964]


Superfamily statistics
Genomes (1,628) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,595 74,513 125
Proteins 18,207 59,713 121


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00029640.000000000001163Least InformativeDirect
Biological Process (BP)biological regulation0.0051670.00009955Least InformativeInherited
Biological Process (BP)multicellular organismal process0.006160.00000000002572Least InformativeInherited
Biological Process (BP)immune system process0.000000018530Moderately InformativeDirect
Biological Process (BP)defense response0.0000012570Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.00013210.0002098Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.001040.00000000000003101Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.035330.82Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0097441Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.009830.001831Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00000071260.00228Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.035231Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.045660.1025Moderately InformativeInherited
Biological Process (BP)single organism signaling0.021090.08131Moderately InformativeInherited
Biological Process (BP)cell communication0.042820.004447Moderately InformativeInherited
Biological Process (BP)immune response0.000000057040.000000000001854InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.0008750.01472InformativeInherited
Biological Process (BP)response to bacterium0.0022110.0002608InformativeInherited
Biological Process (BP)defense response to other organism0.27150.2122InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0012261InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00010420.5748InformativeInherited
Biological Process (BP)regulation of immune response0.0031240InformativeInherited
Biological Process (BP)positive regulation of immune system process0.20540.0000000000008618InformativeInherited
Biological Process (BP)regulation of defense response10.01068InformativeInherited
Biological Process (BP)biological adhesion0.000000032020.00000000000246Highly InformativeDirect
Biological Process (BP)regulation of response to wounding0.0000050450.1052Highly InformativeInherited
Biological Process (BP)antimicrobial humoral response0.0000010010.008599Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation0.000075890.1486Highly InformativeInherited
Biological Process (BP)activation of innate immune response0.011490.2967Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.6170.9083Highly InformativeInherited
Molecular Function (MF)binding0.000000000001350.00000000000006593Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.18650.000001381Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.26190.00000000000001156Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.16140.03948Moderately InformativeInherited
Molecular Function (MF)molecular transducer activity0.000032850InformativeDirect
Molecular Function (MF)calcium ion binding0.00046040.0000000001544Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.0000820Highly InformativeDirect
Cellular Component (CC)extracellular region part0.00017050Moderately InformativeDirect
Cellular Component (CC)cell surface0.000058930InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000000002572 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000001163 Least Informative Direct
Biological Process (BP) biological regulation 0.00009955 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.05679 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0002098 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000000003101 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8592 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.8643 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.00228 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1025 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.82 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1123 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.523 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.08131 Moderately Informative Inherited
Biological Process (BP) cell communication 0.004447 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2325 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.8969 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001831 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02538 Moderately Informative Inherited
Biological Process (BP) cell activation 0.000000001488 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0001232 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000000000008618 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000004322 Informative Direct
Biological Process (BP) immune response 0.000000000001854 Informative Direct
Biological Process (BP) mitochondrion organization 0.00000589 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00001658 Informative Direct
Biological Process (BP) response to bacterium 0.0002608 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000000000122 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00007504 Informative Direct
Biological Process (BP) locomotion 0.000000000005742 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0005132 Informative Direct
Biological Process (BP) localization of cell 0.0000958 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.007713 Informative Inherited
Biological Process (BP) regulation of ion transport 0.0712 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) cell development 0.8243 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9106 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.7451 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.01472 Informative Inherited
Biological Process (BP) secretion by cell 0.02134 Informative Inherited
Biological Process (BP) response to wounding 0.004952 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.44 Informative Inherited
Biological Process (BP) defense response to other organism 0.2122 Informative Inherited
Biological Process (BP) regulation of defense response 0.01068 Informative Inherited
Biological Process (BP) response to oxidative stress 0.4959 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001355 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.5748 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1761 Informative Inherited
Biological Process (BP) generation of neurons 0.3989 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.007035 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) immune effector process 0.01586 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01409 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.00002181 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.000006001 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.000002068 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.00000000003015 Highly Informative Direct
Biological Process (BP) muscle system process 0.000000003141 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.000006343 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000000000246 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.000801 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) granulocyte activation 0.000003263 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0004036 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.00000002566 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000161 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0004341 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.0002102 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0.000006944 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00004246 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00001241 Highly Informative Direct
Biological Process (BP) aging 0.08507 Highly Informative Inherited
Biological Process (BP) neuron development 0.005365 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.1052 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.506 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.3814 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.01217 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.6831 Highly Informative Inherited
Biological Process (BP) wound healing 0.005065 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02627 Highly Informative Inherited
Biological Process (BP) antimicrobial humoral response 0.008599 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.4052 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.06437 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.01037 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.5037 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.1486 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.02502 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 0.2967 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.9083 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.001001 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.3217 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1223 Highly Informative Inherited
Biological Process (BP) innate immune response 0.02079 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000006593 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.0002543 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000000001156 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000001381 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01462 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.03948 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.0000000194 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000001975 Informative Direct
Molecular Function (MF) enzyme binding 0.008823 Informative Inherited
Molecular Function (MF) receptor binding 0.001037 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.1352 Informative Inherited
Molecular Function (MF) signal transducer activity 0.003837 Informative Inherited
Molecular Function (MF) calcium ion binding 0.0000000001544 Highly Informative Direct
Molecular Function (MF) heparin binding 0.000000000354 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.02441 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.19 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001438 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.8557 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1456 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) secretory granule 0.0000001153 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0001095 Informative Direct
Cellular Component (CC) side of membrane 0.000000000000003036 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000001233 Informative Direct
Cellular Component (CC) plasma membrane region 0.4779 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.6939 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.000282 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.00000005296 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.1493 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.000000004817InformativeDirect
Biological processCytolysis0.0002053InformativeDirect
Biological processAngiogenesis0.0005354InformativeDirect
Biological processAcute phase0.00000000003331Highly InformativeDirect
Biological processHemolysis0.00002115Highly InformativeDirect
Biological processAdaptive immunity0.0004955Highly InformativeDirect
Biological processComplement pathway0.0007244Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Coding sequence diversityPolymorphism0.00004205Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.000000777Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainImmunoglobulin domain0.00000001567InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
DomainLaminin EGF-like domain0.0000000001269Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0.0000000009166InformativeDirect
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the C-type lectin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]