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Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (182) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,402 16,498 21
Proteins 5,216 15,843 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.08381Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.004274InformativeInherited
Disease Ontology (DO)congenital afibrinogenemia0.0000003126Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.483Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5409Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.549Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5938Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.7005Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7028Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.08555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1056Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.135Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.195Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.2058Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.2378Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3638Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.0001732InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.000238InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.0002437InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.001472InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the coagulation cascade0.001804InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombosis0.006364InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.05069InformativeInherited
Phenotypic Abnormality (PA)Edema0.0566InformativeInherited
Phenotypic Abnormality (PA)Abnormal spleen morphology0.0575InformativeInherited
Phenotypic Abnormality (PA)Splenic rupture0.000000006041Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous abortion0.000007843Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.00002728Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating fibrinogen0.00002885Highly InformativeDirect
Phenotypic Abnormality (PA)Joint swelling0.00005919Highly InformativeDirect
Phenotypic Abnormality (PA)Menometrorrhagia0.00007362Highly InformativeDirect
Phenotypic Abnormality (PA)Venous thrombosis0.0007047Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2878Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)sensory system0Moderately InformativeDirect
Fly Anatomy (FA)eo-type sensillum0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]