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Nitric oxide (NO) synthase oxygenase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nitric oxide (NO) synthase oxygenase domain [ 56511]
Superfamily:   Nitric oxide (NO) synthase oxygenase domain [ 56512]
Families:   Nitric oxide (NO) synthase oxygenase domain [ 56513]


Superfamily statistics
Genomes (343) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 582 2,996 31
Proteins 566 2,976 31


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system cancer0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect
Disease Ontology (DO)brain disease0Moderately InformativeDirect
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)nephritis0InformativeDirect
Disease Ontology (DO)migraine0InformativeDirect
Disease Ontology (DO)peripheral nervous system neoplasm0InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0InformativeDirect
Disease Ontology (DO)asthma0InformativeDirect
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)lupus erythematosus0Highly InformativeDirect
Disease Ontology (DO)Alzheimer's disease0Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0Highly InformativeDirect
Disease Ontology (DO)ischemia0Highly InformativeDirect
Disease Ontology (DO)autonomic nervous system neoplasm0Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal myeloid cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urination0InformativeDirect
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0InformativeDirect
Mammalian Phenotype (MP)increased body weight0InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton development0InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal glucose homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal smooth muscle morphology0InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal ion homeostasis0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0InformativeDirect
Mammalian Phenotype (MP)seizures0InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol level0InformativeDirect
Mammalian Phenotype (MP)abnormal fertility/fecundity0InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0InformativeDirect
Mammalian Phenotype (MP)polydipsia0Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0Highly InformativeDirect
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovulation cycle0Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR004030 SSF56512 Protein matches
Abstract

Nitric oxide synthase (NOS) enzymes produce nitric oxide (NO) by catalyzing a five-electron oxidation of a guanidino nitrogen of L-arginine (L-Arg). Oxidation of L-Arg to L-citrulline occurs via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine as an intermediate. 2 mol of O(2) and 1.5 mol of NADPH are consumed per mole of NO formed [PubMed8782597].

Arginine-derived NO synthesis has been identified in mammals, fish, birds, invertebrates, plants, and bacteria [PubMed8782597]. Best studied are mammals, where three distinct genes encode NOS isozymes: neuronal (nNOS or NOS-1), cytokine-inducible (iNOS or NOS-2) and endothelial (eNOS or NOS-3) [PubMed7510950]. iNOS and nNOS are soluble and found predominantly in the cytosol, while eNOS is membrane associated. The enzymes exist as homodimers, each monomer consisting of two major domains: an N-terminal oxygenase domain, which belongs to the class of heme-thiolate proteins, and a C-terminal reductase domain, which is homologous to NADPH:P450 reductase . The interdomain linker between the oxygenase and reductase domains contains a calmodulin (CaM)-binding sequence. NOSs are the only enzymes known to simultaneously require five bound cofactors animal NOS isozymes are catalytically self-sufficient. The electron flow in the NO synthase reaction is: NADPH --> FAD --> FMN --> heme --> O(2).

eNOS localisation to endothelial membranes is mediated by cotranslational N-terminal myristoylation and post-translational palmitoylation [PubMed9199168]. The subcellular localisation of nNOS in skeletal muscle is mediated by anchoring of nNOS to dystrophin. nNOS contains an additional N-terminal domain, the PDZ domain [PubMed7535955]. Some bacteria, like Bacillus halodurans, Bacillus subtilis or Deinococcus radiodurans, contain homologs of NOS oxygenase domain. The pattern is directed against the N-terminal heme binding site.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nitric oxide (NO) synthase oxygenase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Nitric oxide (NO) synthase oxygenase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]