SUPERFAMILY 1.73 HMM library and genome assignments server


HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   HAD-like [ 56783]
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
Superfamily:   HAD-like [ 56784] (23)
Families:   Probable phosphatase YrbI [ 69467]
  the insertion subdomain is a beta-hairpin involved into tetramerisation
  HAD-related [ 56785] (2)
  the insertion subdomain is a 4-helical bundle
  beta-Phosphoglucomutase-like [ 75173] (9)
  the insertion subdomain is a 4-helical bundle
  YihX-like [ 56789] (2)
  the insertion subdomain is a 4-helical bundle
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  the insertion subdomain is a 4-helical bundle
  Phosphoserine phosphatase [ 64511]
  the insertion subdomain is a 4-helical bundle
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
  Homoserine kinase ThrH [ 102304]
  the insertion subdomain is a rudiment 4-helical bundle
  Class B acid phosphatase, AphA [ 102307]
  the insertion subdomain is a helical hairpin
  Hypothetical protein MW1667 (SA1546) [ 102310]
  the insertion subdomain is multi-helical
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  no insertion subdomains
  Predicted hydrolases Cof [ 82388] (11)
  contains an alpha+beta subdomain inserted into a new site after strand 3
  NagD-like [ 102317] (6)
  duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  interrupted by a large insertion, domain N
  Trehalose-phosphatase [ 110506]
  Pfam 02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family
  NLI interacting factor-like phosphatase [ 110509]
  Pfam 03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  the insertion subdomain is a 3-stranded beta-sheet different from the NIF family
  Hypothetical protein VC0232 [ 117512]
  contains a deletion in the common fold; segment-swapped tetramer
  Histidinol phosphatase [ 142177]
  no insertion subdomains
  MtnX-like [ 142180]
  Pfam 06888; the insertion subdomain is a rudiment 4-helical bundle
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Pfam 05822; the insertion subdomain is a rudiment 4-helical bundle
  Enolase-phosphatase E1 [ 142186] (2)
  the insertion subdomain is a 4-helical bundle
  5' nucleotidase-like [ 142191]
  Pfam 05761; the insertion domain cosists of 3-helical bundle and a pseudo beta-barrel; contains extra C-terminal long alpha hairpin subdomain (scop_cf 46556)


Superfamily statistics
Genomes (1,369) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 38,992 32,793 71
Proteins 38,883 32,732 71


Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]