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Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (142) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 3,325 48
Proteins 966 3,310 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3805Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0003831Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000448Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.007041Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01772Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01813Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1154Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)overnutrition0.00003626InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001116InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001191InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001849InformativeInherited
Disease Ontology (DO)liver disease0.005829InformativeInherited
Disease Ontology (DO)pancreas disease0.1591InformativeInherited
Disease Ontology (DO)hyperandrogenism0.00000008696Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.00000371Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00008965Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.1053Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1572Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.04332Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1625Moderately InformativeInherited
Phenotypic Abnormality (PA)Hypoglycemia0.0001321InformativeDirect
Phenotypic Abnormality (PA)Decreased body weight0.03083InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04028Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1299Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00005592Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal glucose homeostasis0.02418InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.05085InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1194InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000002494Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0007754Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.001205Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000000008417Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.006174Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2415Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000000009962Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000000001054Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.002375Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.6007Moderately InformativeInherited
Worm Phenotype (WP)body bend variant0.00000000003421InformativeDirect
Worm Phenotype (WP)body posture variant0.0000007335InformativeDirect
Worm Phenotype (WP)localized movement variant0.000006966InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00007694InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001903InformativeDirect
Worm Phenotype (WP)small0.0002111InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0002657InformativeDirect
Worm Phenotype (WP)directionality variant0.01052InformativeInherited
Worm Phenotype (WP)organism temperature response variant0.05358InformativeInherited
Worm Phenotype (WP)locomotion reduced0.7847InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)dauer development variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.000000000003337Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0000000000153Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000000002174Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.000005175Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0005456Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0003015Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]