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Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (142) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 3,325 48
Proteins 966 3,310 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3805Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0003831Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000448Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.007041Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01772Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01813Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1154Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)overnutrition0.00003626InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001116InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001191InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001849InformativeInherited
Disease Ontology (DO)liver disease0.005829InformativeInherited
Disease Ontology (DO)pancreas disease0.1591InformativeInherited
Disease Ontology (DO)hyperandrogenism0.00000008696Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.00000371Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00008965Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.1016Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.155Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2477Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.0414Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1578Moderately InformativeInherited
Phenotypic Abnormality (PA)Hypoglycemia0.0001246InformativeDirect
Phenotypic Abnormality (PA)Decreased body weight0.0292InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04024Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.13Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00005604Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal glucose homeostasis0.0242InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.05082InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1194InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.0000025Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0007762Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.001205Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000003569Least InformativeDirect
Worm Phenotype (WP)cell development variant0.05593Least InformativeInherited
Worm Phenotype (WP)larval development variant0.9364Least InformativeInherited
Worm Phenotype (WP)body morphology variant0.00000003868Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000002508Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000002508Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000002531Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.000002554Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003427Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1052Moderately InformativeInherited
Worm Phenotype (WP)body bend variant0.00000000002476InformativeDirect
Worm Phenotype (WP)body posture variant0.0000002837InformativeDirect
Worm Phenotype (WP)localized movement variant0.000001219InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00001512InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0001093InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001984InformativeDirect
Worm Phenotype (WP)small0.0002188InformativeDirect
Worm Phenotype (WP)directionality variant0.01147InformativeInherited
Worm Phenotype (WP)locomotion reduced0.8InformativeInherited
Worm Phenotype (WP)dauer arrest variant0Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.000000000002784Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.00000000001412Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000000001896Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000004733Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0006048Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0002436Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]