SUPERFAMILY 1.75 HMM library and genome assignments server

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Insulin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Family:   Insulin-like [ 56995] (4)

Family statistics
Genomes (64) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 212 941 9
Proteins 212 941 9

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.344Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003294Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.005835Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01463Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01466Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.09947Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition0.00002747InformativeDirect
Disease Ontology (DO)interstitial lung disease0.00009403InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001404InformativeInherited
Disease Ontology (DO)liver disease0.004786InformativeInherited
Disease Ontology (DO)pancreas disease0.1238InformativeInherited
Disease Ontology (DO)polycystic ovary syndrome0.0000008597Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.000002395Highly InformativeDirect
Disease Ontology (DO)Parkinson's disease0.00005966Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00006761Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.0000841Highly InformativeDirect
Disease Ontology (DO)liver cirrhosis0.0001379Highly InformativeDirect
Disease Ontology (DO)gonadal disease0.006322Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.07627Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1312Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2085Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.0205Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.02477Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.03306Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1349Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.001973InformativeInherited
Phenotypic Abnormality (PA)Deviation of finger0.0004441Highly InformativeDirect
Phenotypic Abnormality (PA)Clinodactyly0.0005496Highly InformativeDirect
Phenotypic Abnormality (PA)Intrauterine growth retardation0.0006607Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00007126Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.01859Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03326Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1134Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0008025Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1612Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4506Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.001266InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.008075InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.07231InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.09715InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.4566InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000001372Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0001236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.0002046Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0004369Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0000006159Least InformativeDirect
Worm Phenotype (WP)cell development variant0.3329Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00000001005Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0006043Moderately InformativeDirect
Worm Phenotype (WP)dauer arrest variant0InformativeDirect
Worm Phenotype (WP)body length variant0.000000007491InformativeDirect
Worm Phenotype (WP)body width variant0.0000000184InformativeDirect
Worm Phenotype (WP)body posture variant0.0000008086InformativeDirect
Worm Phenotype (WP)localized movement variant0.00001175InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0001108InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001986InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0002232InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.003903InformativeInherited
Worm Phenotype (WP)locomotion reduced0.8198InformativeInherited
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00000000003667Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.000000000128Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0000000001764Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.00001431Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0006417Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant0.0184Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)decreased fecundity0.0001804Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]