SUPERFAMILY 1.75 HMM library and genome assignments server

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Scorpion toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Scorpion toxin-like [ 57095] (5)
Families:   Long-chain scorpion toxins [ 57096] (4)
  Short-chain scorpion toxins [ 57116] (34)
  Defensin MGD-1 [ 57160]
  Insect defensins [ 57163] (5)
  Plant defensins [ 57170] (8)


Superfamily statistics
Genomes (119) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,007 3,798 99
Proteins 996 3,772 99


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00.00000000000002102Least InformativeDirect
Biological Process (BP)defense response00Moderately InformativeDirect
Biological Process (BP)response to external stimulus0.000000000060640.000000000006188Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)defense response to other organism0.000087230.00000006511InformativeDirect
Biological Process (BP)interspecies interaction between organisms0.017760.00249InformativeInherited
Biological Process (BP)pathogenesis0.00000029230.00000003515Highly InformativeDirect
Biological Process (BP)response to fungus00Highly InformativeDirect
Molecular Function (MF)molecular function regulator00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000000002102 Least Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000006188 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) defense response to other organism 0.00000006511 Informative Direct
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.00249 Informative Inherited
Biological Process (BP) pathogenesis 0.00000003515 Highly Informative Direct
Biological Process (BP) response to fungus 0 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.00007593 Highly Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityRNA editing0.0000000004071Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainKnottin0Highly InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationNeurotoxin0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationAmidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 74 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Scorpion toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 74 hidden Markov models representing the Scorpion toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]