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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06444Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004488Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.008848Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1133Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1201Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.00007173InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002304InformativeDirect
Disease Ontology (DO)malignant glioma0.0004312InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.0757InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3374InformativeInherited
Disease Ontology (DO)neurofibroma0.000001183Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008401Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001026Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009536Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02174Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.829Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.00386InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.3031Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001107Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01383Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08637Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1297Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2081Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2251Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6147Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001966Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005174Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0000998Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000199Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001179Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00129Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001309Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001333Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0037Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02944Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2601Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009729InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00007023InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002452InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.009128InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03187InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1349InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.245InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3824InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3993InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4208InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4635InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4833InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5876InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007486Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002249Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001175Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.000162Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002613Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002725Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005483Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.0006307Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.05666Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.0853Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1013Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6284Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6311Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0001586Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0002007Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002241Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02313Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1253Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1376Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4178Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7653Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0001445Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.02733Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1973Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2728Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00006791InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00007805InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002251InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003936InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0005577InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.003116InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000004641Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001377Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003538Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000009299Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00001019Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002179Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00003451Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00008876Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0004719Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0003885InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0004153InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.08298Least InformativeInherited
Fly Anatomy (FA)anatomical group0.248Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3117Least InformativeInherited
Fly Anatomy (FA)nervous system0.367Least InformativeInherited
Fly Anatomy (FA)adult0.3938Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4363Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5436Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02383Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.03976Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06622Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.07623Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.08059Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1427Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2117Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2128Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2153Moderately InformativeInherited
Fly Anatomy (FA)gonad0.2381Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.261Moderately InformativeInherited
Fly Anatomy (FA)head0.3327Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.367Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4848Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.495Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5638Moderately InformativeInherited
Fly Anatomy (FA)appendage0.7119Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.747Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.8039Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.8958Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00006513InformativeDirect
Fly Anatomy (FA)adult heart0.000212InformativeDirect
Fly Anatomy (FA)endocuticle0.0008398InformativeDirect
Fly Anatomy (FA)tracheal system0.001008InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01011InformativeInherited
Fly Anatomy (FA)adult external head0.01371InformativeInherited
Fly Anatomy (FA)interneuron0.01384InformativeInherited
Fly Anatomy (FA)muscle system0.01417InformativeInherited
Fly Anatomy (FA)anatomical space0.01419InformativeInherited
Fly Anatomy (FA)primordium0.01577InformativeInherited
Fly Anatomy (FA)wing blade0.01713InformativeInherited
Fly Anatomy (FA)syncytium0.01985InformativeInherited
Fly Anatomy (FA)male organism0.05944InformativeInherited
Fly Anatomy (FA)cuticular specialization0.1147InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1375InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.1471InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.1646InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1902InformativeInherited
Fly Anatomy (FA)tract0.3253InformativeInherited
Fly Anatomy (FA)neuroblast0.755InformativeInherited
Fly Anatomy (FA)hub cell0.000001861Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.000009264Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00004405Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001546Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0002068Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002586Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0007027Highly InformativeDirect
Fly Anatomy (FA)acute muscle0.001654Highly InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.001964Highly InformativeInherited
Fly Anatomy (FA)ventral nerve cord primordium0.006143Highly InformativeInherited
Fly Anatomy (FA)embryonic neuroblast0.0206Highly InformativeInherited
Fly Anatomy (FA)wing vein0.0664Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.1114Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.002378Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.1875Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8993Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001727Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03965Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7719Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.01555InformativeInherited
Zebrafish Anatomy (ZA)intramembranous bone0.0000837Highly InformativeDirect
Zebrafish Anatomy (ZA)lymphatic system0.0006943Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.005984Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.7906Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.008153Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.09695Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2178Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6177Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7457Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000698Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.005711Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.6968Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.000005735InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000006669InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00001001InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0000488InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0002281InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0002963InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0004966InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01918InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.03753InformativeInherited
Xenopus ANatomical entity (XAN)tail0.2571InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.2777InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.00006164Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00006385Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0001532Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0006891Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuromere0.0007176Highly InformativeDirect
Xenopus ANatomical entity (XAN)proximal tubule0.0008962Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.01926Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.8047Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0004766Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.7558Moderately InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000002621Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007482InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]