SUPERFAMILY 1.75 HMM library and genome assignments server

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Growth factor receptor domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Family:   Growth factor receptor domain [ 57185] (8)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,418 4,221 21
Proteins 1,035 2,959 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0007136Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000002121Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.005651Least InformativeInherited
Disease Ontology (DO)cell type cancer0.0004214Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.005034Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.03909Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.0516Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.05413Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.06108Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.09088Moderately InformativeInherited
Disease Ontology (DO)liver carcinoma0.00001976InformativeDirect
Disease Ontology (DO)urinary system cancer0.00003346InformativeDirect
Disease Ontology (DO)physical disorder0.0001152InformativeDirect
Disease Ontology (DO)large intestine cancer0.0001715InformativeDirect
Disease Ontology (DO)osteosarcoma0.000173InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0003726InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0006389InformativeDirect
Disease Ontology (DO)lung carcinoma0.00064InformativeDirect
Disease Ontology (DO)malignant glioma0.000755InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.1419InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1612InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.2181InformativeInherited
Disease Ontology (DO)neurofibroma0.00000002208Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.000005917Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.00001083Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0002157Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.0754Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1429Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.0003571Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.02InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.09976InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1824InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.2461InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.3085InformativeInherited
Phenotypic Abnormality (PA)Ventricular septal defect0.0002959Highly InformativeDirect
Phenotypic Abnormality (PA)Bicuspid aortic valve0.0008202Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000004263Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.002719Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.08641Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.187Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3946Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4469Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.000001356Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.00001054Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0003846Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0006085Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001214Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.002157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.002374Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004632Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.02808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.08383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1464Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2983Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4316Moderately InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.00007406InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0007592InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.01222InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.02968InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.07702InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08781InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.1094InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1775InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.2137InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2373InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3417InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.3572InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.6164InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.8426InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular cushion morphology0.000004527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001174Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.0001174Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000306Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0005973Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0006558Highly InformativeDirect
Mammalian Phenotype (MP)sex reversal0.0007106Highly InformativeDirect
Mammalian Phenotype (MP)abnormal insulin secretion0.02806Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.1946Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4109Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.002172Least InformativeInherited
Worm Phenotype (WP)cell development variant0.007314Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1933Least InformativeInherited
Worm Phenotype (WP)larval lethal0.3907Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0008765Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000896Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.9024Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00002989InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00005679InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.001485InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.0206InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.000001023Highly InformativeDirect
Worm Phenotype (WP)molt variant0.000002833Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00000496Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000006019Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0003324Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0004444Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0002884InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000306InformativeDirect
Fly Phenotype (FP)immune response defective0.0009147InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1261Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1869Least InformativeInherited
Fly Anatomy (FA)segment0.2901Least InformativeInherited
Fly Anatomy (FA)tagma0.382Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4227Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4456Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6217Least InformativeInherited
Fly Anatomy (FA)adult0.677Least InformativeInherited
Fly Anatomy (FA)digestive system0.0131Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02566Moderately InformativeInherited
Fly Anatomy (FA)circulatory system0.02849Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05304Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.1404Moderately InformativeInherited
Fly Anatomy (FA)gonad0.167Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1702Moderately InformativeInherited
Fly Anatomy (FA)appendage0.1835Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3634Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval tracheal system0.00002965InformativeDirect
Fly Anatomy (FA)adult external head0.003381InformativeInherited
Fly Anatomy (FA)anatomical space0.004564InformativeInherited
Fly Anatomy (FA)leg0.007458InformativeInherited
Fly Anatomy (FA)appendage segment0.01921InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.02912InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.05789InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.06847InformativeInherited
Fly Anatomy (FA)proventriculus0.00005071Highly InformativeDirect
Fly Anatomy (FA)somatic cell of testis0.00009063Highly InformativeDirect
Fly Anatomy (FA)integumentary specialisation0.0001095Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001511Highly InformativeDirect
Fly Anatomy (FA)primary lobe of embryonic/larval lymph gland0.0002934Highly InformativeDirect
Fly Anatomy (FA)salivary gland0.0004538Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0004857Highly InformativeDirect
Fly Anatomy (FA)germinal proliferation center0.0005527Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.0008384Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.01471Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.2801Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.003379Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1123Moderately InformativeInherited
Zebrafish Anatomy (ZA)otic epithelium0.0009073Highly InformativeDirect
Zebrafish Anatomy (ZA)anatomical conduit0.001526Highly InformativeInherited
Zebrafish Anatomy (ZA)pars superior ear0.0111Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.03907Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.0429Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1265Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2002Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.3406Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.8942Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00003182Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004414Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.4714Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0000004899InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00003559InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003868InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00006933InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000752InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0002763InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0006445InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.1775InformativeInherited
Xenopus ANatomical entity (XAN)fin0.000248Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.000000000004983Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.001322Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.1241Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.0000004861InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.0006891InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]