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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (281) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 76,348 214,533 117
Proteins 23,656 69,342 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.02251Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03204Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1463Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6974Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0003032InformativeDirect
Disease Ontology (DO)atherosclerosis0.0009571InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0002263Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0004228Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.02632Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.298Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.7116Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.03606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.04187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.07985Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1139Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.6517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.0007073InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.4771InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.4941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.5132InformativeInherited
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.1373Highly InformativeInherited
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.4023Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00000008308Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.01155Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02281Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02906Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1302Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5282Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8258Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.00001462Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0000994Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0001112Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001334Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002169Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001185Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.003967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03681Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3811Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.000000303InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0001883InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0006699InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.006702InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03637InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03781InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.06229InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1024InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1285InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1706InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1787InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2298InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2415InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4675InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.588InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.595InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7463InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000000005164Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002198Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002198Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.00008209Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00008846Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0001155Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0005125Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.0005641Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland duct morphology0.0006494Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0008856Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0009397Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.008616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01289Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.317Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9274Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000001146Least InformativeDirect
Worm Phenotype (WP)larval lethal0.002317Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.003581Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.008642Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0189Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6255Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0005147Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.001906Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.05782Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.08616Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1196Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6069Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.0000001293InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0006243InformativeDirect
Worm Phenotype (WP)VPC competence variant0.003023InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.007597InformativeInherited
Worm Phenotype (WP)vulva development variant0.01823InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.0368InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000003997Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00006391Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.000198Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0002009Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0002873Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.0003211Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0005548Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0009899Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.002533Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01377Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.01737Highly InformativeInherited
Worm Phenotype (WP)neuropil development variant0.02158Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.3032Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.5355Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.3531Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.001217Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0000003429InformativeDirect
Fly Phenotype (FP)planar polarity defective0.00004257InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0004436InformativeDirect
Fly Phenotype (FP)size defective0.007626InformativeInherited
Fly Phenotype (FP)cell number defective0.01834InformativeInherited
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000008163Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000001542Highly InformativeDirect
Fly Phenotype (FP)cell migration defective0.0002315Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0.0003627Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.04471Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.06964Least InformativeInherited
Fly Anatomy (FA)adult0.07649Least InformativeInherited
Fly Anatomy (FA)larva0.07792Least InformativeInherited
Fly Anatomy (FA)anatomical group0.08315Least InformativeInherited
Fly Anatomy (FA)nervous system0.2185Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4811Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00001971Moderately InformativeDirect
Fly Anatomy (FA)developing embryonic structure0.01173Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01468Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01623Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02371Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.03024Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.03331Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.03654Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.05708Moderately InformativeInherited
Fly Anatomy (FA)appendage0.07107Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09319Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1454Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1881Moderately InformativeInherited
Fly Anatomy (FA)head0.2341Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2495Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.3127Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3435Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7286Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.8719Moderately InformativeInherited
Fly Anatomy (FA)endocuticle0.000003162InformativeDirect
Fly Anatomy (FA)primordium0.0001038InformativeDirect
Fly Anatomy (FA)wing blade0.0004223InformativeDirect
Fly Anatomy (FA)muscle system0.0007715InformativeDirect
Fly Anatomy (FA)syncytium0.0008101InformativeDirect
Fly Anatomy (FA)digestive system0.00276InformativeInherited
Fly Anatomy (FA)tracheal system0.002954InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.002981InformativeInherited
Fly Anatomy (FA)abdominal segment0.003219InformativeInherited
Fly Anatomy (FA)hemocyte0.003272InformativeInherited
Fly Anatomy (FA)larval abdomen0.006851InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007148InformativeInherited
Fly Anatomy (FA)adult external head0.01007InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.03251InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.0583InformativeInherited
Fly Anatomy (FA)cell component0.06095InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.07522InformativeInherited
Fly Anatomy (FA)gastrula embryo0.1484InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.1742InformativeInherited
Fly Anatomy (FA)male organism0.2217InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.3004InformativeInherited
Fly Anatomy (FA)hub cell0.00005003Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001615Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0006158Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0008698Highly InformativeDirect
Fly Anatomy (FA)pigment cell0.0008846Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0008865Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0009639Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.002188Highly InformativeInherited
Fly Anatomy (FA)early extended germ band embryo0.02083Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.06513Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.09259Highly InformativeInherited
Fly Anatomy (FA)longitudinal muscle0.1635Highly InformativeInherited
Fly Anatomy (FA)acute muscle0.2782Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0001605Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.2115Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9832Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.006444Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03523Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.596Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.00003132Highly InformativeDirect
Zebrafish Anatomy (ZA)multi fate stem cell0.0009238Highly InformativeDirect
Zebrafish Anatomy (ZA)ganglion0.05595Highly InformativeInherited
Zebrafish Anatomy (ZA)inner ear0.07847Highly InformativeInherited
Zebrafish Anatomy (ZA)lateral line system0.1451Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.6974Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9211Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01031Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1741Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.4591Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002317InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000956InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.008846InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.01042InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.00001125Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00001561Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000339Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0006671Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0008631Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001811Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.9902InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0008345Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0001132Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0003338InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.1376InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 64 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 64 hidden Markov models representing the EGF/Laminin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]