SUPERFAMILY 1.75 HMM library and genome assignments server

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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (281) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 76,348 179,056 117
Proteins 23,656 57,550 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000002572 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000006968 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000000009829 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000000002342 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0004252 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000001031 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000007411 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000006379 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0009907 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000006013 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000004234 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5371 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9609 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7455 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.4386 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001284 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1151 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9943 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9947 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9686 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8971 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8465 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.3345 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0106 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00001771 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.00000002904 Informative Direct
Biological Process (BP) behavior 0.00000000000002102 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0000000008506 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00002779 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00001043 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000002765 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000000000001418 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of growth 0.00000000000004085 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000000004597 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00005719 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.00008543 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000001541 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00002055 Informative Direct
Biological Process (BP) cell development 0.000000000001951 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00002893 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000000008181 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000000001763 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000000006679 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000001042 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0002869 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002042 Informative Direct
Biological Process (BP) circulatory system development 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1742 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.002226 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.6152 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8047 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.03588 Informative Inherited
Biological Process (BP) protein oligomerization 0.0218 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.7394 Informative Inherited
Biological Process (BP) system process 0.595 Informative Inherited
Biological Process (BP) generation of neurons 0.07764 Informative Inherited
Biological Process (BP) negative regulation of transport 0.3133 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.6685 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00628 Informative Inherited
Biological Process (BP) epithelium development 0.2536 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.2166 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005388 Informative Inherited
Biological Process (BP) secondary metabolic process 0.8964 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3573 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.6214 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.5496 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001866 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.003863 Informative Inherited
Biological Process (BP) phosphorylation 0.05466 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5321 Informative Inherited
Biological Process (BP) response to radiation 0.3932 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) protein transport 0.5234 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.5753 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) immune response 0.7403 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.04238 Informative Inherited
Biological Process (BP) proteolysis 0.3597 Informative Inherited
Biological Process (BP) embryo development 0.01668 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) cell activation 0.8968 Informative Inherited
Biological Process (BP) hemopoiesis 0.3812 Informative Inherited
Biological Process (BP) immune effector process 0.1641 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.4167 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2707 Informative Inherited
Biological Process (BP) MAPK cascade 0.000002256 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001158 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000002323 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000000000009834 Highly Informative Direct
Biological Process (BP) kidney development 0.00002377 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.000000000001279 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000001789 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.0000005692 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.000001278 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0001396 Highly Informative Direct
Biological Process (BP) heart development 0.0000006579 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00000008755 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00001557 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000000006013 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000000004492 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.000000004809 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000001687 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00001271 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) forebrain development 0.0000000001299 Highly Informative Direct
Biological Process (BP) regeneration 0.00005992 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0007188 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00005395 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000001819 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00000000988 Highly Informative Direct
Biological Process (BP) wound healing 0.00000001639 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00000000213 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0000401 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000003357 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0001311 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00000000002385 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000000003624 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00009082 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00000001739 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000006814 Highly Informative Direct
Biological Process (BP) neuron development 0.00000004609 Highly Informative Direct
Biological Process (BP) appendage development 0.000000000002619 Highly Informative Direct
Biological Process (BP) coagulation 0.00000000986 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.0004271 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00000000256 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000000003104 Highly Informative Direct
Biological Process (BP) protein maturation 0.000000001433 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000000000001251 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000000001213 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0001183 Highly Informative Direct
Biological Process (BP) response to growth factor 0 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00008183 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0000005491 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000000246 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.0000005785 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000000001301 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000000004717 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.000000000006144 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.007674 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.002787 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.01358 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.004357 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.01407 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.08901 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1967 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.05919 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.03307 Highly Informative Inherited
Biological Process (BP) regulation of interleukin-1 production 0.001212 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.002289 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.002046 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6722 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.02306 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.1686 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.3947 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.9846 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.747 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.001963 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 1 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.2137 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.1177 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.4088 Highly Informative Inherited
Biological Process (BP) maintenance of location 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01437 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.04086 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.05538 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.4356 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.4751 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.0196 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.04347 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.2014 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.9825 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.196 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.747 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1692 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.007439 Highly Informative Inherited
Biological Process (BP) viral process 0.1335 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.6356 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.001008 Highly Informative Inherited
Biological Process (BP) protein import 0.04411 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.127 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.05516 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.9533 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.8153 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.6909 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.118 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.09186 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5545 Highly Informative Inherited
Biological Process (BP) gastrulation 0.1104 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.002224 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.00881 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.005288 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000003392 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0000000009743 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002003 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6565 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.4218 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001374 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000000024 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0002062 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000000001152 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000000004728 Informative Direct
Molecular Function (MF) enzyme binding 0.7619 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001485 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.03363 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.1074 Informative Inherited
Molecular Function (MF) signal transducer activity 0.0508 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.9609 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.01009 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.615 Informative Inherited
Molecular Function (MF) phospholipid binding 0.5448 Informative Inherited
Molecular Function (MF) protease binding 0.00002671 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.00002494 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0006846 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0009034 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.00000000003671 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.00004701 Highly Informative Direct
Molecular Function (MF) heme binding 0.0001306 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00001756 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0001082 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0001371 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0998 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.1456 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.9543 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.7327 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1004 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00003406 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.7956 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.02526 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.4468 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.2314 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00006066 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000000000009741 Informative Direct
Cellular Component (CC) apical part of cell 0.00000000000003104 Informative Direct
Cellular Component (CC) side of membrane 0.00000000355 Informative Direct
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.1267 Informative Inherited
Cellular Component (CC) vacuolar part 0.009404 Informative Inherited
Cellular Component (CC) lytic vacuole 0.0116 Informative Inherited
Cellular Component (CC) secretory granule 0.02975 Informative Inherited
Cellular Component (CC) neuron projection 0.08221 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.001732 Informative Inherited
Cellular Component (CC) membrane region 0.008006 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.6101 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.0005513 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00000000000009234 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.0000009409 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000009115 Highly Informative Direct
Cellular Component (CC) main axon 0.00000002085 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.00002537 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.2946 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.02718 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0.00000000000987Moderately InformativeDirect
Biological processHost-virus interaction0.00005932Moderately InformativeDirect
Biological processLipid metabolism0.09093Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processInflammatory response0.0000001233InformativeDirect
Biological processWnt signaling pathway0.000003351InformativeDirect
Biological processInnate immunity0.00002272InformativeDirect
Biological processSteroid metabolism0.0001394InformativeDirect
Biological processFatty acid metabolism0.0005354InformativeDirect
Biological processSensory transduction0.000627InformativeDirect
Biological processLipid biosynthesis0.6541InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement pathway0.00000000000001079Highly InformativeDirect
Biological processUnfolded protein response0.0000000000000287Highly InformativeDirect
Biological processPhagocytosis0.000000000001072Highly InformativeDirect
Biological processFertilization0.00000003287Highly InformativeDirect
Biological processCholesterol metabolism0.0000007703Highly InformativeDirect
Biological processVision0.0002709Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.000000001857Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000003832Moderately InformativeDirect
Cellular componentEndosome0.0004375Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.000001548InformativeDirect
Cellular componentBasement membrane0.0000000000009451Highly InformativeDirect
Cellular componentSarcoplasmic reticulum0.000000000004471Highly InformativeDirect
Cellular componentCoated pit0.00000001809Highly InformativeDirect
Cellular componentMicrosome0.000008186Highly InformativeDirect
Coding sequence diversityPolymorphism0.000005059Moderately InformativeDirect
Developmental stageMerozoite0InformativeDirect
DiseaseDisease mutation0.0000009242Least InformativeDirect
DiseaseMalaria0.0000000431InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000000000003893Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
DomainKringle0.00000000000004664Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationGrowth factor binding0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationPeroxidase8.797e-16Highly InformativeDirect
Post-translational modificationDioxygenase0.0000000001682Highly InformativeDirect
Post-translational modificationG-protein coupled receptor0.0000000737Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.000003545Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000000006247Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.000001769InformativeDirect
Post-translational modificationSulfation0.0001107InformativeDirect
Post-translational modificationZymogen0.0008451InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 64 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 64 hidden Markov models representing the EGF/Laminin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]