SUPERFAMILY 1.75 HMM library and genome assignments server

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EGF-type module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Family:   EGF-type module [ 57197] (22)


Family statistics
Genomes (2) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3 9 3
Proteins 3 9 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.001093Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.746e-16Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000008316Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000008316Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4452Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.004467Moderately InformativeInherited
Disease Ontology (DO)artery disease0.07266Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.253Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.3154Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.04101InformativeInherited
Disease Ontology (DO)primary thrombocytopenia0.00003425Highly InformativeDirect
Disease Ontology (DO)gastritis0.0006161Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0009948Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.005763Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.005675Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.214Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3615Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.02313Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.1199Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3049Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.0007404InformativeDirect
Phenotypic Abnormality (PA)Hernia0.003065InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.003144InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.01924InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.1157InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.9781InformativeInherited
Phenotypic Abnormality (PA)Ventricular septal defect0.000004344Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.00003753Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal atrioventricular valve physiology0.0005495Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic valve stenosis0.0007848Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.0009986Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001162Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.02578Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.06479Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1275Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.146Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2533Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3393Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0001416Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001066Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.002958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.01148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.03258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.08174Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3373Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.6396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.7684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.8094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000001187InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.004438InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.01975InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.0355InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.04249InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.05289InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.06073InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.06762InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.1215InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.1339InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.141InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.1715InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1744InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1819InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.2181InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.3059InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3949InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.484InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00001617Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002992Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.00007082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.0002173Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tendon morphology0.0003041Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000577Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.0005976Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.0006332Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0006497Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.01881Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.03075Highly InformativeInherited
Mammalian Phenotype (MP)increased bone mass0.06346Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.2562Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology0.2969Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.3475Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.3689Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory ganglion morphology0.4328Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.2354Least InformativeInherited
Worm Phenotype (WP)movement variant0.02942Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1673Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.004312Moderately InformativeInherited
Fly Phenotype (FP)planar polarity defective0.000008224InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0001549InformativeDirect
Fly Phenotype (FP)cell number defective0.006306InformativeInherited
Fly Phenotype (FP)size defective0.01608InformativeInherited
Fly Phenotype (FP)increased occurrence of cell division0.00004036Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0003619Highly InformativeDirect
Fly Phenotype (FP)some die during pupal stage0.0007447Highly InformativeDirect
Fly Phenotype (FP)neoplasia0.02188Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.1006Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1987Least InformativeInherited
Fly Anatomy (FA)larva0.2405Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2612Least InformativeInherited
Fly Anatomy (FA)tagma0.3036Least InformativeInherited
Fly Anatomy (FA)adult0.3532Least InformativeInherited
Fly Anatomy (FA)somatic cell0.475Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5404Least InformativeInherited
Fly Anatomy (FA)nervous system0.5739Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00001225Moderately InformativeDirect
Fly Anatomy (FA)circulatory system0.001107Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.002045Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.004254Moderately InformativeInherited
Fly Anatomy (FA)digestive system0.01681Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02805Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.04357Moderately InformativeInherited
Fly Anatomy (FA)gonad0.06349Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1912Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.236Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.2931Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3532Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.0001183InformativeDirect
Fly Anatomy (FA)adult external head0.0002808InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0.0003029InformativeDirect
Fly Anatomy (FA)adult heart0.000387InformativeDirect
Fly Anatomy (FA)anatomical space0.0004349InformativeDirect
Fly Anatomy (FA)antennal segment0.001171InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.004978InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.0111InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.01545InformativeInherited
Fly Anatomy (FA)midgut0.01622InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.02055InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.02435InformativeInherited
Fly Anatomy (FA)syncytium0.02979InformativeInherited
Fly Anatomy (FA)muscle cell0.04601InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.1841InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.274InformativeInherited
Fly Anatomy (FA)ventral nervous system0.000008952Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00004057Highly InformativeDirect
Fly Anatomy (FA)primary lobe of embryonic/larval lymph gland0.0002271Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0003253Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0005767Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0006511Highly InformativeDirect
Fly Anatomy (FA)endocuticle0.0006724Highly InformativeDirect
Fly Anatomy (FA)somatic cell of testis0.001031Highly InformativeInherited
Fly Anatomy (FA)germinal proliferation center0.007297Highly InformativeInherited
Fly Anatomy (FA)nephrocyte0.01077Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.2542Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval hypodermal muscle0.2682Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.4069Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8126Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1347Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.9836Moderately InformativeInherited
Zebrafish Anatomy (ZA)otic epithelium0.0001223Highly InformativeDirect
Zebrafish Anatomy (ZA)anatomical conduit0.0006002Highly InformativeDirect
Zebrafish Anatomy (ZA)pars superior ear0.001819Highly InformativeInherited
Zebrafish Anatomy (ZA)peripheral nervous system0.1223Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0004665InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00009716Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0003129Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.1554Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]