SUPERFAMILY 1.75 HMM library and genome assignments server

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Laminin-type module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Family:   Laminin-type module [ 57233]


Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 57 127 3
Proteins 57 127 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.05711Moderately InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.00000002909Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.01785Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.02104Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.09175Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3359Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.542Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.002692Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1178Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.1191Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.1529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1717Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.203Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.2624Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3076Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.7371Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.0000539InformativeDirect
Phenotypic Abnormality (PA)Epidermal thickening0.01468InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.02237InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.07684InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.1411InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.1477InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.1488InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.1707InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.3208InformativeInherited
Phenotypic Abnormality (PA)Weak cry0.000001216Highly InformativeDirect
Phenotypic Abnormality (PA)Squamous cell carcinoma of the skin0.000004611Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal larynx morphology0.0001198Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory insufficiency0.0001565Highly InformativeDirect
Phenotypic Abnormality (PA)Atypical scarring of skin0.0002896Highly InformativeDirect
Phenotypic Abnormality (PA)EMG abnormality0.0004484Highly InformativeDirect
Phenotypic Abnormality (PA)Palmoplantar keratoderma0.0006196Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent skin infections0.0009852Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.0025Highly InformativeInherited
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.01216Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the skin0.0133Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal esophagus morphology0.01961Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental structure0.0199Highly InformativeInherited
Phenotypic Abnormality (PA)Sparse hair0.02859Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.03015Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx physiology0.04569Highly InformativeInherited
Phenotypic Abnormality (PA)Alopecia0.06077Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.1457Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0008431Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.005393Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1364Least InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.003176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.004842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.005517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.005544Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.009343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.03624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.07147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.1629Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.000252InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell morphology0.0005573InformativeDirect
Mammalian Phenotype (MP)abnormal mouth morphology0.0005894InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0.01144InformativeInherited
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.1575InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1671InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3018InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000000001009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle mass0.0001899Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.0003002Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0003054Highly InformativeDirect
Mammalian Phenotype (MP)abnormal somatic motor system morphology0.002067Highly InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus basement membrane morphology0.005319Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.1172Highly InformativeInherited
Mammalian Phenotype (MP)abnormal involuntary movement0.1339Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0003615Least InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00001668Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00005799Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00005799Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00005828Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00005857Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00006318Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.00007482Moderately InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00007615InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001087InformativeDirect
Worm Phenotype (WP)egg laying variant0.1018InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000001586Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.0000001943Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000006461Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.00005992Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0001366Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0InformativeDirect
Fly Anatomy (FA)muscle cell0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)syncytium0InformativeDirect
Fly Anatomy (FA)epithelial tube0InformativeDirect
Fly Anatomy (FA)embryonic/larval dorsal vessel0Highly InformativeDirect
Fly Anatomy (FA)nephrocyte0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1086Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)electrically active cell0.1892Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle cell0.2362InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.242InformativeInherited
Zebrafish Anatomy (ZA)slow muscle cell0.0004507Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]