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Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,053 12,772 76
Proteins 3,718 11,554 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1963Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.01973Moderately InformativeInherited
Disease Ontology (DO)artery disease0.391Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8283Moderately InformativeInherited
Disease Ontology (DO)asthma0.0007383InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001886Highly InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0002549Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1982Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4481Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7181Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02537Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.03143Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03382Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2837Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2854Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3123Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.3915Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.01276InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.02543InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04855InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.111InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.1799InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2305InformativeInherited
Phenotypic Abnormality (PA)Abnormal sputum0.0002817Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.0003293Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal subarachnoid space morphology0.0007276Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.000988Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.00189Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.003317Highly InformativeInherited
Phenotypic Abnormality (PA)Intracranial hemorrhage0.04341Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.08519Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0109Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.03892Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.0006755InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1031InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0000002057Highly InformativeDirect
Mammalian Phenotype (MP)absent allantois0.00006388Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0002016Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary circulation0.0005883Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0009392Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology0.04314Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.8826Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.005527InformativeInherited
Worm Phenotype (WP)fat content reduced0.0001996Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1791Least InformativeInherited
Fly Phenotype (FP)lethal0.02158Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0001398InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0.1484Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.182Least InformativeInherited
Fly Anatomy (FA)adult0.1836Least InformativeInherited
Fly Anatomy (FA)larva0.306Least InformativeInherited
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)appendage0.007923Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01255Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.01655Moderately InformativeInherited
Fly Anatomy (FA)thorax0.01948Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02301Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02984Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05706Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.06098Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.06849Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1076Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2001Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.3896Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.00001813InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0.00008977InformativeDirect
Fly Anatomy (FA)cell component0.0005847InformativeDirect
Fly Anatomy (FA)tracheal system0.0006124InformativeDirect
Fly Anatomy (FA)larval segment0.0006667InformativeDirect
Fly Anatomy (FA)cuticular specialization0.006859InformativeInherited
Fly Anatomy (FA)leg0.008061InformativeInherited
Fly Anatomy (FA)germarium0.01117InformativeInherited
Fly Anatomy (FA)epithelial tube0.01332InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.01472InformativeInherited
Fly Anatomy (FA)germline cell0.1128InformativeInherited
Fly Anatomy (FA)wing0.5264InformativeInherited
Fly Anatomy (FA)neuromuscular junction0.00001473Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.00006237Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0001565Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0002468Highly InformativeDirect
Fly Anatomy (FA)tarsal segment0.0005139Highly InformativeDirect
Fly Anatomy (FA)wing vein0.0007863Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.2113Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.07306Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1129Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1673Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3304Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.698Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8262Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002924Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00392Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.05398Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.0000008162InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.00006224InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0001128InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0003287InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0004002InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.00000001163Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0000004715Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000004858Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00001535Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00005441Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0004192Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]