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Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,053 12,772 76
Proteins 3,718 11,554 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1963Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.01973Moderately InformativeInherited
Disease Ontology (DO)artery disease0.391Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8283Moderately InformativeInherited
Disease Ontology (DO)asthma0.0007383InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001886Highly InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0002549Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1923Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4434Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.712Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02506Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.0286Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03265Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2736Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2846Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3081Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.0131InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.02505InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04892InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1124InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.181InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2344InformativeInherited
Phenotypic Abnormality (PA)Abnormal sputum0.0002904Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00034Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal subarachnoid space morphology0.0007114Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0009849Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.001882Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.003314Highly InformativeInherited
Phenotypic Abnormality (PA)Intracranial hemorrhage0.04402Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.08501Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01091Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.03894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.0006759InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1031InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.000000206Highly InformativeDirect
Mammalian Phenotype (MP)absent allantois0.00006395Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0002016Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary circulation0.0005883Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0009397Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology0.04316Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.8414Least InformativeInherited
Worm Phenotype (WP)fat content variant0.00403InformativeInherited
Worm Phenotype (WP)fat content reduced0.0001779Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1868Least InformativeInherited
Fly Phenotype (FP)lethal0.02219Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0001402InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.2001Least InformativeInherited
Fly Anatomy (FA)adult0.2068Least InformativeInherited
Fly Anatomy (FA)larva0.2953Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)appendage0.008828Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01408Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.0185Moderately InformativeInherited
Fly Anatomy (FA)thorax0.02163Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.0252Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.03288Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05698Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1146Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2002Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.4066Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.0000968InformativeDirect
Fly Anatomy (FA)cell component0.0005449InformativeDirect
Fly Anatomy (FA)tracheal system0.0007436InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.005InformativeInherited
Fly Anatomy (FA)cuticular specialization0.007599InformativeInherited
Fly Anatomy (FA)leg0.008232InformativeInherited
Fly Anatomy (FA)wing blade0.01037InformativeInherited
Fly Anatomy (FA)epithelial tube0.01423InformativeInherited
Fly Anatomy (FA)male organism0.01871InformativeInherited
Fly Anatomy (FA)ovariole0.05475InformativeInherited
Fly Anatomy (FA)germline cell0.1138InformativeInherited
Fly Anatomy (FA)female germline stem cell0.00006819Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0001626Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0002688Highly InformativeDirect
Fly Anatomy (FA)tarsal segment0.0005587Highly InformativeDirect
Fly Anatomy (FA)wing vein0.0008764Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.009706Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.2107Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.07313Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.113Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1649Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3317Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6992Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8286Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.002243Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002947Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.05435Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.000000824InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0000643InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0001135InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000324InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0003999InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.00000001186Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0000004814Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000004818Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0000153Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000539Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0004138Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]