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Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,053 12,772 76
Proteins 3,718 11,554 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1963Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.01973Moderately InformativeInherited
Disease Ontology (DO)artery disease0.391Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8283Moderately InformativeInherited
Disease Ontology (DO)asthma0.0007383InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001886Highly InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0002549Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1923Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4434Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.712Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02506Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.0286Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03265Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2736Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2846Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3081Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.0131InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.02505InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04892InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1124InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.181InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.2344InformativeInherited
Phenotypic Abnormality (PA)Abnormal sputum0.0002904Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00034Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal subarachnoid space morphology0.0007114Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0009849Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.001882Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.003314Highly InformativeInherited
Phenotypic Abnormality (PA)Intracranial hemorrhage0.04402Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.08502Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01091Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.03894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.0006757InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1031InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.000000206Highly InformativeDirect
Mammalian Phenotype (MP)absent allantois0.00006395Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0002017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary circulation0.0005881Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0009399Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology0.04313Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.8403Least InformativeInherited
Worm Phenotype (WP)fat content variant0.003997InformativeInherited
Worm Phenotype (WP)fat content reduced0.0001763Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.188Least InformativeInherited
Fly Phenotype (FP)lethal0.022Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0001377InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult0.1199Least InformativeInherited
Fly Anatomy (FA)larva0.1658Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2007Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.009622Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01505Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.02003Moderately InformativeInherited
Fly Anatomy (FA)thorax0.02104Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.0259Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.0308Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.03316Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05526Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.07409Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1139Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1962Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5663Moderately InformativeInherited
Fly Anatomy (FA)cell component0.0005166InformativeDirect
Fly Anatomy (FA)tracheal system0.000757InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.007388InformativeInherited
Fly Anatomy (FA)cuticular specialization0.007606InformativeInherited
Fly Anatomy (FA)wing blade0.01037InformativeInherited
Fly Anatomy (FA)epithelial tube0.0136InformativeInherited
Fly Anatomy (FA)male organism0.01859InformativeInherited
Fly Anatomy (FA)ovariole0.05473InformativeInherited
Fly Anatomy (FA)germline cell0.1134InformativeInherited
Fly Anatomy (FA)female germline stem cell0.00007012Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.0001682Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0002673Highly InformativeDirect
Fly Anatomy (FA)wing vein0.0009017Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.009998Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.2111Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.0734Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1132Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.167Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3319Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7007Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8286Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002974Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.05477Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.000000823InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.00006453InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0001069InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0003068InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0003904InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.00000001232Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0000003462Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000004775Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00001591Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000519Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0004264Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]