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Snake toxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Families:   Snake venom toxins [ 57303] (27)
  Dendroaspin [ 57351]
  Extracellular domain of cell surface receptors [ 57354] (6)


Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,053 12,772 76
Proteins 3,718 11,554 68


Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cardiovascular system disease0.007779Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1962Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.01972Moderately InformativeInherited
Disease Ontology (DO)artery disease0.3909Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8285Moderately InformativeInherited
Disease Ontology (DO)asthma0.0007378InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001886Highly InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0002547Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1896Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4089Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6948Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02654Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03168Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.07101Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2665Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.272Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2788Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3064Moderately InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.006215InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.02442InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04857InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1167InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.221InformativeInherited
Phenotypic Abnormality (PA)Subarachnoid hemorrhage0.00004715Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal sputum0.0003482Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.0003482Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricular function0.0009653Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.002055Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.002979Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.08524Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01091Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.03885Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4382Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.0006816InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1032InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0000002059Highly InformativeDirect
Mammalian Phenotype (MP)absent allantois0.00006397Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic-extraembryonic boundary morphology0.0002024Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary circulation0.0005893Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0009441Highly InformativeDirect
Mammalian Phenotype (MP)abnormal primitive streak morphology0.04329Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1872Least InformativeInherited
Fly Phenotype (FP)lethal0.02161Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0001361InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult0.1196Least InformativeInherited
Fly Anatomy (FA)larva0.1636Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1977Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.009739Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01537Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.02055Moderately InformativeInherited
Fly Anatomy (FA)thorax0.02095Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02609Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.03333Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05477Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1146Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1975Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.4048Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5567Moderately InformativeInherited
Fly Anatomy (FA)cell component0.000409InformativeDirect
Fly Anatomy (FA)tracheal system0.0007333InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.007024InformativeInherited
Fly Anatomy (FA)cuticular specialization0.007652InformativeInherited
Fly Anatomy (FA)wing blade0.01058InformativeInherited
Fly Anatomy (FA)germarium0.01145InformativeInherited
Fly Anatomy (FA)epithelial tube0.01367InformativeInherited
Fly Anatomy (FA)male organism0.01881InformativeInherited
Fly Anatomy (FA)germline cell0.1164InformativeInherited
Fly Anatomy (FA)female germline stem cell0.00006907Highly InformativeDirect
Fly Anatomy (FA)epithelial furrow0.000166Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0002742Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.00965Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1983Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.07375Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.107Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1644Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3306Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.693Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8263Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.001673Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002454Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.05089Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8216Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.0000005225InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.00005956InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00006944InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0002143InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0003211InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.00000001049Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.00000005555Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000002946Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00001596Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00003884Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0004411Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0006144Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Snake toxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]