SUPERFAMILY 1.75 HMM library and genome assignments server

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Neurotrophin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Family:   Neurotrophin [ 57520] (4)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 297 7,207 9
Proteins 297 7,206 9


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)asthma0InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006667Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)postnatal growth retardation0InformativeDirect
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0.0001228InformativeDirect
Mammalian Phenotype (MP)abnormal sensory ganglion morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal involuntary movement0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.00004168Highly InformativeDirect
Mammalian Phenotype (MP)infertility0.000826Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cranial ganglia morphology0.00716Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cystine-knot cytokines domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]