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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (176) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 31,786 84,109 82
Proteins 6,968 19,171 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06666Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0000001044Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0006361Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0006462Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.02076Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.0304Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.07993Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.01425InformativeInherited
Disease Ontology (DO)nephritis0.03088InformativeInherited
Disease Ontology (DO)degeneration of macula and posterior pole0.0000000002208Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1986Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2104Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4366Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.7478Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.9862Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.0002557Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.009731Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.153Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.1608Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.2189Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3809Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.562Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.713Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.000006381InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.000313InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.0007317InformativeDirect
Phenotypic Abnormality (PA)Generalized abnormality of skin0.002094InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.005594InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.01576InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.02629InformativeInherited
Phenotypic Abnormality (PA)Edema0.05984InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.454InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.6045InformativeInherited
Phenotypic Abnormality (PA)Recurrent Neisserial infections0.000002146Highly InformativeDirect
Phenotypic Abnormality (PA)Yellow/white lesions of the retina0.0007002Highly InformativeDirect
Phenotypic Abnormality (PA)Diarrhea0.0009589Highly InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0.001258Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enzyme/coenzyme activity0.05607Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07225Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2649Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7397Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01868Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.00515InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00605InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.02341InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.0578InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.101InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1441InformativeInherited
Mammalian Phenotype (MP)biphasic excitatory postsynaptic current amplitude0.00000007289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0000005484Highly InformativeDirect
Mammalian Phenotype (MP)short excitatory postsynaptic current rise time0.00001441Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0001706Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.0002139Highly InformativeDirect
Mammalian Phenotype (MP)lymph node hypoplasia0.0006308Highly InformativeDirect
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.02647Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.04157Highly InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.05008Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.09625Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.5747Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.02314Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4463Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000003035InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000001332InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]