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TB module/8-cys domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TB module/8-cys domain [ 57580]
Superfamily:   TB module/8-cys domain [ 57581]
Families:   TB module/8-cys domain [ 57582] (2)

Superfamily statistics
Genomes (105) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,234 9,135 3
Proteins 732 2,165 3

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.1789Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.03546Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3631Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.6362Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.01814InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.06063InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.07765InformativeInherited
Phenotypic Abnormality (PA)Ectopia lentis0.000001842Highly InformativeDirect
Phenotypic Abnormality (PA)Mitral valve prolapse0.00002238Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal tracheobronchial morphology0.001019Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02861Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0007516Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.06524Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1418Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.00004743Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.009976Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.0159Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.1395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2189Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.2797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.00005514InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.0001579InformativeDirect
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.0005811InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.09627InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000004185Highly InformativeDirect
Mammalian Phenotype (MP)abnormal incisor morphology0.00003529Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0003686Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR002212 SSF57581 Protein matches

Transforming growth factor beta (TGF-beta)-binding protein-like (TB) domain comes from human fibrillin-1[PubMed8364578]. This domain is found in fibrillins and latent TGF-beta-binding proteins (LTBPs) which are localized to fibrillar structures in the extracellular matrix.[PubMed9362480].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a TB module/8-cys domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the TB module/8-cys domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]