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TNF receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TNF receptor-like [ 57585]
Superfamily:   TNF receptor-like [ 57586] (2)
Families:   TNF receptor-like [ 57587] (5)
  BAFF receptor-like [ 90174] (3)


Superfamily statistics
Genomes (117) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,273 9,605 36
Proteins 1,709 5,117 16


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002958Least InformativeInherited
Disease Ontology (DO)nervous system disease0.8136Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.000000000000258Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000008045Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.0000001167Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.000001618Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.00005411Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0006238Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.02235Moderately InformativeInherited
Disease Ontology (DO)artery disease0.7184Moderately InformativeInherited
Disease Ontology (DO)arthritis0.00000000000006044InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.000001666InformativeDirect
Disease Ontology (DO)alopecia0.0002046InformativeDirect
Disease Ontology (DO)multiple sclerosis0.000399InformativeDirect
Disease Ontology (DO)breast cancer0.0004218InformativeDirect
Disease Ontology (DO)atherosclerosis0.0007536InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.01628InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.02287InformativeInherited
Disease Ontology (DO)arthropathy0.1741InformativeInherited
Disease Ontology (DO)lupus erythematosus0.00000000001601Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia0.00000005029Highly InformativeDirect
Disease Ontology (DO)spondyloarthropathy0.00007139Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.2232Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01547Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3312Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3629Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8217Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.005859Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.008929Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.1193Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.2764Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.9762Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of B cell physiology0.000001173InformativeDirect
Phenotypic Abnormality (PA)Abnormal spleen morphology0.00001992InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.0001853InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.0005981InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.002856InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.0269InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.03688InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.9598InformativeInherited
Phenotypic Abnormality (PA)Abnormal immunoglobulin level0.00000107Highly InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.000002798Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphoma0.00001622Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.00004748Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent respiratory infections0.2103Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.000002479Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000003259Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6052Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6204Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0000000009061Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000000462Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.001484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.02009Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.05645Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.07062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.07267Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08223Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1207Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.6632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.9726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.00000008221InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000005977InformativeDirect
Mammalian Phenotype (MP)abnormal humoral immune response0.0003943InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0004944InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.0006646InformativeDirect
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.001762InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.009443InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.02048InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.0353InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.144InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1501InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.1749InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3679InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.4235InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4983InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.5284InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.5809InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.7054InformativeInherited
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG1 level0.000000003214Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node B cell domain morphology0.000008841Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0000282Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system regeneration0.00003574Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2a level0.00003621Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001396Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0001839Highly InformativeDirect
Mammalian Phenotype (MP)increased anti-nuclear antigen antibody level0.0002362Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002456Highly InformativeDirect
Mammalian Phenotype (MP)skin lesions0.0003313Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0.0006862Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus epithelium morphology0.0006975Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0009046Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0009118Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.001008Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.003211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.00768Highly InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.1574Highly InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.6476Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TNF receptor-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the TNF receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]