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beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (573) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 283,318 732,602 212
Proteins 83,479 249,271 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001626Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.9354Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1159Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.666Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.1865InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00006276Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001428Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00131Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.0309Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.002229Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.002229Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.002253Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.00228Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.003023Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.8633Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9075Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.00000004372InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0002264InformativeDirect
Worm Phenotype (WP)protruding vulva0.0003652InformativeDirect
Worm Phenotype (WP)male morphology variant0.0005173InformativeDirect
Worm Phenotype (WP)egg laying variant0.1998InformativeInherited
Worm Phenotype (WP)drug resistant0.2271InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.000008089Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.03225Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.00000000126Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000005191Least InformativeDirect
Fly Anatomy (FA)nervous system1Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)region of integument0.000000000000001901Moderately InformativeDirect
Fly Anatomy (FA)thorax0.00000000000003226Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.000000000001238Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.0000000003186Moderately InformativeDirect
Fly Anatomy (FA)central nervous system1Moderately InformativeInherited
Fly Anatomy (FA)neuron1Moderately InformativeInherited
Fly Anatomy (FA)ganglion1Moderately InformativeInherited
Fly Anatomy (FA)subesophageal ganglion0.01882Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.2909Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.668Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7015Least InformativeInherited
Zebrafish Anatomy (ZA)cell1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3017Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.2037InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.6612Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1297Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.258Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0193InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1645InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural ridge0.00006052Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0002449Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.002587Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001856Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 100.0001089Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7781Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003773InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002415Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004596Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00002115Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.003594Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.02285Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0000000003686InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.0000000000002455Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]