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beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (573) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 283,318 732,602 212
Proteins 83,479 249,271 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0006722Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.9352Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.1167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6626Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.1868InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00002903Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000364Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001054Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006511Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.01429Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.05863Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9394Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.00000005518InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0002193InformativeDirect
Worm Phenotype (WP)protruding vulva0.0003898InformativeDirect
Worm Phenotype (WP)male morphology variant0.0004971InformativeDirect
Worm Phenotype (WP)egg laying variant0.307InformativeInherited
Worm Phenotype (WP)drug resistant0.3361InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.3632InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.000008192Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.00629Highly InformativeInherited
Worm Phenotype (WP)sex determination variant0.03026Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.000000005109Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000005788Least InformativeDirect
Fly Anatomy (FA)nervous system1Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0000000000001914Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0000000000002706Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.0000000002742Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0.0000004021Moderately InformativeDirect
Fly Anatomy (FA)central nervous system1Moderately InformativeInherited
Fly Anatomy (FA)neuron1Moderately InformativeInherited
Fly Anatomy (FA)ganglion1Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.3123Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6933Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.751Least InformativeInherited
Zebrafish Anatomy (ZA)cell1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3459Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.2782InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5385Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.09241Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2417Moderately InformativeInherited
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.0006619InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01839InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.0001594Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0008961Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.003172Highly InformativeInherited
Xenopus ANatomical entity (XAN)non-neural ectoderm0.004854Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001537Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)gastrula stage0.00004825Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7782Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003757InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002404Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004575Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00002318Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.01362Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.05624Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.485e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0000000001824InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.00000000000001841Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]