SUPERFAMILY 1.75 HMM library and genome assignments server

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Classic zinc finger, C2H2 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Family:   Classic zinc finger, C2H2 [ 57668] (30)


Family statistics
Genomes (54) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 138 348 3
Proteins 138 348 3


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1457Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.324Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02076Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.04811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.2575InformativeInherited
Phenotypic Abnormality (PA)Polydactyly0.005925Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.9005Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.005626Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.02921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.0008423InformativeDirect
Mammalian Phenotype (MP)abnormal long bone morphology0.001738InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.06582InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.002493Least InformativeInherited
Worm Phenotype (WP)cell number increased0.00009297InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.0008251Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.0008988Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0000001196Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.00007673Least InformativeDirect
Fly Anatomy (FA)adult0.001389Least InformativeInherited
Fly Anatomy (FA)tagma0.001963Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.004143Least InformativeInherited
Fly Anatomy (FA)anatomical group0.7241Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.00000000002407Moderately InformativeDirect
Fly Anatomy (FA)appendage0.0000000121Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.00000002405Moderately InformativeDirect
Fly Anatomy (FA)developing embryonic structure0.002981Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2749Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.3495Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.432Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.517Moderately InformativeInherited
Fly Anatomy (FA)ganglion mother cell0.4007InformativeInherited
Fly Anatomy (FA)embryonic/larval head sense organ0.001769Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval sensillum0.001893Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.7683Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.8349Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.8623Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9223Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5681Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.1409InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5743Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.5991Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8785Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8822Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.06161Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1137Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1539Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6634Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0006115InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.001046InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.03005InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001438Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001919Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00002627Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0003077Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0003349Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0005771Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.003588Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0004811Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)gastrula stage0.000005719Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00001891InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0.000000000001006Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]