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Zn2/Cys6 DNA-binding domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Regulation |
| Detailed category | DNA-binding |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR001138 SSF57701 Protein matches |
| Abstract | The N-terminal region of a number of fungal transcriptional regulatory
proteins contains a Cys-rich motif that is involved in zinc-dependent
binding of DNA. The region forms a binuclear Zn cluster, in which two Zn
atoms are bound by six Cys residues
[ 2107541, 1557122].
A wide range of proteins are known to contain this domain. These include the
proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose
metabolism; amide and GABA catabolism; leucine biosynthesis and others.
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 7 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Zn2/Cys6 DNA-binding domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 7 hidden Markov models representing the Zn2/Cys6 DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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