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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2386Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06628Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4681Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06083InformativeInherited
Disease Ontology (DO)physical disorder0.1493InformativeInherited
Disease Ontology (DO)viral infectious disease0.3131InformativeInherited
Disease Ontology (DO)gallbladder disease0.00006747Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001504Highly InformativeDirect
Disease Ontology (DO)rubella0.0001851Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9513Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.06522Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.2635Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3144Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1271InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.2176InformativeInherited
Phenotypic Abnormality (PA)Abnormal testis morphology0.5018InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0007813Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pancreas morphology0.00389Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000001325Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002409Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007048Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.000383Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005417Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3803Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4139Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4608Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002485Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004881Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0005069Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005135Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.002946Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.004341Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006053Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008672Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03438Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06844Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.13Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005486InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001529InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.001024InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001137InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.00799InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03727InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03969InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0469InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06116InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3673InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3845InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4353InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5036InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6587InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9327InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004638Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007097Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002225Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002225Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000004426Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.00000473Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007304Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002043Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004409Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001678Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003102Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0003246Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003648Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004476Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007428Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007666Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.00236Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02177Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02428Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03463Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03845Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07914Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3049Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3552Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01024Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00000001238Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.6778Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.8582Moderately InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.02131InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000001854Highly InformativeDirect
Worm Phenotype (WP)fat content increased0.000017Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.000059Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0001639Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0008703Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.002347Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01751Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000009125Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.001143Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01003Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.00001107Moderately InformativeDirect
Fly Anatomy (FA)region of integument0.00005099Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001398Moderately InformativeDirect
Fly Anatomy (FA)thorax0.0005978Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.02499Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.2643Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.01918Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1881Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.2194Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6002Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2134InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.4615InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.0006685Highly InformativeDirect
Zebrafish Anatomy (ZA)heart0.05961Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09786Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3437Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.7694Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.835Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.947Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000337Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0007456Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.5374Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.9042Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9398Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.000001021InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000008921InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00001319InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00003872InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0008214InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.008926InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.01103InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.633InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.00000001959Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuromere0.000001791Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior placodal area0.00001953Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0000672Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00009141Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0008802Highly InformativeDirect
Xenopus ANatomical entity (XAN)proximal tubule0.006888Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.009852Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.4574Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.00009014Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0002293InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5912InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000001182Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]