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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2391Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06625Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.468Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06083InformativeInherited
Disease Ontology (DO)physical disorder0.1493InformativeInherited
Disease Ontology (DO)viral infectious disease0.313InformativeInherited
Disease Ontology (DO)gallbladder disease0.00006761Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001507Highly InformativeDirect
Disease Ontology (DO)rubella0.0001851Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0007206Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3038Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4081Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9912Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.138Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.3073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4862Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.9671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1155InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.2294InformativeInherited
Phenotypic Abnormality (PA)Abnormal testis morphology0.7217InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0008073Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pancreas morphology0.007074Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.2312Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000000132Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002361Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007087Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003808Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005392Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3801Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4147Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4613Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0004791Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0005048Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.000511Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.002894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.004348Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006095Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03438Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005149InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001502InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00102InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001134InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007979InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03727InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03967InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0469InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06101InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3673InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3845InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4354InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4763InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5035InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6582InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9328InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9643InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004071Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007097Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002224Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002224Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.00000442Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004721Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007291Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002038Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004405Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001667Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003105Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0003249Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.000364Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004469Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007402Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007641Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002349Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003418Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01586Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02176Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02428Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03464Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03845Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07915Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3049Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3553Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.08178Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0000002882Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.8878Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.000000474InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.01191InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.2791InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)fat content increased0.00001896Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00006039Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002048Highly InformativeDirect
Worm Phenotype (WP)social behavior variant0.01807Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.000000124InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.002688Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.005736Least InformativeInherited
Fly Anatomy (FA)adult0.006146Least InformativeInherited
Fly Anatomy (FA)appendage0.0000001449Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.000006104Moderately InformativeDirect
Fly Anatomy (FA)region of integument0.00002789Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.0000686Moderately InformativeDirect
Fly Anatomy (FA)thorax0.0005151Moderately InformativeDirect
Fly Anatomy (FA)adult tagma0.00414Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.06075Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.3413Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.02744Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1193Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.4223Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2507InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.2963InformativeInherited
Zebrafish Anatomy (ZA)heart0.01213Highly InformativeInherited
Zebrafish Anatomy (ZA)CNS interneuron0.2619Highly InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.4287Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02407Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1149Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4405Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.7683Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8412Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9478Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00003868Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000188Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.5738Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8041Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.8527Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00001017InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00003523InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00006404InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004052InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0008223InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.002682InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.03505InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.4797InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.00000002533Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000004562Highly InformativeDirect
Xenopus ANatomical entity (XAN)preplacodal ectoderm0.00001732Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00008731Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002097Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.001946Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.0343Highly InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.06167Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.4529Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001493Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0004584InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5842InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000001656Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]