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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2391Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06625Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.468Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06083InformativeInherited
Disease Ontology (DO)physical disorder0.1493InformativeInherited
Disease Ontology (DO)viral infectious disease0.313InformativeInherited
Disease Ontology (DO)gallbladder disease0.00006761Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001507Highly InformativeDirect
Disease Ontology (DO)rubella0.0001851Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0008161Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3955Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9893Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1358Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.1781Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.3077Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4751Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.9632Moderately InformativeInherited
Phenotypic Abnormality (PA)Gonadal neoplasm0.0561InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1188InformativeInherited
Phenotypic Abnormality (PA)Abnormal testis morphology0.7095InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0008345Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pancreas morphology0.006598Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac atrium morphology0.2126Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000001302Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002373Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007125Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003823Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005405Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3798Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.414Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4608Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0004818Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0005058Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005124Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00436Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006107Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03437Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04668Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06844Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.129Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1969Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2944Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005147InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001507InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00102InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001133InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.008065InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03726InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03966InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.04708InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06119InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3672InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3844InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4354InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4763InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5035InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6583InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9328InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9641InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.000000408Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007115Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002229Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002229Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.00000443Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004734Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007293Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002038Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004409Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003105Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0003246Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003639Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004467Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007405Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007652Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002347Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003415Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01586Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02177Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02427Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03462Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03844Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07912Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3059Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3552Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.02401Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0000001816Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.8618Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9402Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant1Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000005231InformativeDirect
Worm Phenotype (WP)fat content variant0.8499InformativeInherited
Worm Phenotype (WP)fat content increased0.00001708Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00005598Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0001533Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0009567Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.002791Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01805Highly InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.06177Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0000002051InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.01106Least InformativeInherited
Fly Anatomy (FA)adult0.01403Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.0000001618Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.00001302Moderately InformativeDirect
Fly Anatomy (FA)region of integument0.00005507Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.00006376Moderately InformativeDirect
Fly Anatomy (FA)thorax0.0005544Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.279Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.5706Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.03088Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1213Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1397Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.4905Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2129InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.2857InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.0006008Highly InformativeDirect
Zebrafish Anatomy (ZA)heart0.02425Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02452Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1161Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4224Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.7747Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.832Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9451Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001073Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0001962Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.5787Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8076Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.8534Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00001146InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00003609InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00005762InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0003893InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000835InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.002591InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.03244InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.48InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.00000002617Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000003828Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior placodal area0.00003408Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00008216Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002088Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.001851Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.03174Highly InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.06248Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.4589Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001243Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0004591InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5849InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000001676Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]