SUPERFAMILY 1.75 HMM library and genome assignments server

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Nuclear receptor family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Family:   Nuclear receptor [ 57721] (12)


Family statistics
Genomes (141) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,484 10,977 26
Proteins 3,481 10,975 26


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02782Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.000000237Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.005285Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.006763Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.007756Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.04678Moderately InformativeInherited
Disease Ontology (DO)overnutrition0.0000001805InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0001014InformativeDirect
Disease Ontology (DO)hypotrichosis0.0001851InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0001928InformativeDirect
Disease Ontology (DO)physical disorder0.01014InformativeInherited
Disease Ontology (DO)breast carcinoma0.02248InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06693InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.1134InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3331InformativeInherited
Disease Ontology (DO)pancreas disease0.6241InformativeInherited
Disease Ontology (DO)hypospadias0.000004021Highly InformativeDirect
Disease Ontology (DO)gallbladder disease0.00004269Highly InformativeDirect
Disease Ontology (DO)rubella0.00006087Highly InformativeDirect
Disease Ontology (DO)lipid storage disease0.00008531Highly InformativeDirect
Disease Ontology (DO)uterine benign neoplasm0.0002876Highly InformativeDirect
Disease Ontology (DO)breast lobular carcinoma0.0003575Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.0004603Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.0007795Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3772Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.002592Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.4428Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0008326InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.04216InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.7372InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.0001258Highly InformativeDirect
Phenotypic Abnormality (PA)Primary amenorrhea0.0003659Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000003142Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0000178Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001914Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002706Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00006464Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0005618Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.004308Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.007294Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04729Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00000007825Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0000005735Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.00000478Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00002141Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.004018Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.006873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.00934Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.01558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.02499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.05488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.06393Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.06412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.0663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.09924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1251Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.128Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.14Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.5774Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.7369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.00007223InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.0001333InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0003427InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0004009InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0005394InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.001132InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.002139InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.002398InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.002865InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.00363InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.004429InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004833InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.01366InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.03749InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.05679InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.08051InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1172InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.133InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.209InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2306InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.247InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.5915InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.6095InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.6267InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.6387InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.8045InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.9802InformativeInherited
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.000005017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight0.00002017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vasodilation0.0001228Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.0001432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0002291Highly InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0.0002773Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating insulin-like growth factor I level0.0003065Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0003292Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.0003402Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.000393Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.0004582Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0005487Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.0006544Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.0006702Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.0006854Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0007926Highly InformativeDirect
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.0008564Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.0008754Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory conducting tube morphology0.004185Highly InformativeInherited
Mammalian Phenotype (MP)abnormal social/conspecific interaction0.005772Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.006151Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.008428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart tube morphology0.01216Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01291Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.01606Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02031Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.02407Highly InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.02907Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.02978Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.03569Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.03587Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04195Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0525Highly InformativeInherited
Mammalian Phenotype (MP)abnormal temporal bone morphology0.05925Highly InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.06027Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.07425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.0798Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08804Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.09255Highly InformativeInherited
Mammalian Phenotype (MP)vertebral fusion0.1013Highly InformativeInherited
Mammalian Phenotype (MP)abnormal occipital bone morphology0.1069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid hormone level0.1422Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.1888Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.3667Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.6163Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.7578Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0183Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.000001283InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.4745InformativeInherited
Worm Phenotype (WP)fat content variant0.8842InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)fat content increased0.000002726Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.001159Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.02388Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.03751Least InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.00171Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02051Least InformativeInherited
Fly Anatomy (FA)adult0.02066Least InformativeInherited
Fly Anatomy (FA)tagma0.05321Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2124Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2798Least InformativeInherited
Fly Anatomy (FA)nervous system0.5739Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5896Least InformativeInherited
Fly Anatomy (FA)larva0.778Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.004919Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.007581Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1106Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.2067Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.2549Moderately InformativeInherited
Fly Anatomy (FA)neuron0.3041Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.4042Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.00005836InformativeDirect
Fly Anatomy (FA)synaptic neuropil block0.0002169InformativeDirect
Fly Anatomy (FA)neuromere0.003991InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.02221InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.05246InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.07349InformativeInherited
Fly Anatomy (FA)labral segment0.08715InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1726InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2139InformativeInherited
Fly Anatomy (FA)mushroom body intrinsic neuron0.0000006116Highly InformativeDirect
Fly Anatomy (FA)mushroom body gamma-lobe0.000001241Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.000007834Highly InformativeDirect
Fly Anatomy (FA)larval neuromere0.00317Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.02303Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1395Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.757Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7814Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1877Moderately InformativeInherited
Zebrafish Anatomy (ZA)endocrine system0.001561InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.0192InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.03113InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.0902InformativeInherited
Zebrafish Anatomy (ZA)male organism0.00004457Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.0001053Highly InformativeDirect
Zebrafish Anatomy (ZA)gonad0.0001102Highly InformativeDirect
Zebrafish Anatomy (ZA)hypophysis0.0001699Highly InformativeDirect
Zebrafish Anatomy (ZA)otic vesicle0.000468Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]