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Casein kinase II beta subunit superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Rubredoxin-like [ 57769] (17)
Superfamily:   Casein kinase II beta subunit [ 57798]
Families:   Casein kinase II beta subunit [ 57799]


Superfamily statistics
Genomes (495) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,398 3,155 4
Proteins 1,385 3,098 4


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.050390.06241Least InformativeInherited
Biological Process (BP)biological regulation0.000022190.00698Least InformativeInherited
Biological Process (BP)multicellular organismal process0.01630.4165Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.12160.0418Least InformativeInherited
Biological Process (BP)primary metabolic process0.35760.2899Least InformativeInherited
Biological Process (BP)regulation of molecular function0.00000027910.0000003622Moderately InformativeDirect
Biological Process (BP)cellular protein modification process0.00046610.0002022Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.018760.001032Moderately InformativeInherited
Biological Process (BP)reproduction0.00017830.002535Moderately InformativeInherited
Biological Process (BP)regulation of protein modification process0.0000000000037220.000000003642InformativeDirect
Biological Process (BP)phosphorylation0.00000041180.00000003319InformativeDirect
Biological Process (BP)multicellular organism reproduction0.000035080.0004893InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.0000000000002240.002935InformativeInherited
Molecular Function (MF)transferase activity0.086530.08323Least InformativeInherited
Molecular Function (MF)molecular function regulator00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00068630.003197Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000055530.0006633InformativeDirect
Molecular Function (MF)kinase activity0.0002290.001187InformativeInherited
Molecular Function (MF)kinase regulator activity00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.0000077170.0001396Highly InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0000000000049090.0000000003198Least InformativeDirect
Cellular Component (CC)protein kinase CK2 complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.06241 Least Informative Inherited
Biological Process (BP) biological regulation 0.00698 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4165 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.0418 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2899 Least Informative Inherited
Biological Process (BP) regulation of molecular function 0.0000003622 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002022 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.001032 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002535 Moderately Informative Inherited
Biological Process (BP) regulation of protein modification process 0.000000003642 Informative Direct
Biological Process (BP) phosphorylation 0.00000003319 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0004893 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.002935 Informative Inherited
Molecular Function (MF) transferase activity 0.08323 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003197 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0006633 Informative Direct
Molecular Function (MF) kinase activity 0.001187 Informative Inherited
Molecular Function (MF) kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0001396 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000003198 Least Informative Direct
Cellular Component (CC) protein kinase CK2 complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processWnt signaling pathway0InformativeDirect
Coding sequence diversityAlternative splicing0.00007869Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000704 SSF57798 Protein matches
Abstract

Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Ser or Thr in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits [PubMed2666134, PubMed1856204]. However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta') [PubMed7737972]. The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif [PubMed7737972]. The beta subunit is a highly conserved protein of about 25 kD that contains, in its central section, a cysteine-rich motif that could be involved in binding a metal such as zinc [PubMed8027080]. The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase [PubMed7737972].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Casein kinase II beta subunit domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Casein kinase II beta subunit superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]