SUPERFAMILY 1.73 HMM library and genome assignments server


RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (85)
  Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold:   RING/U-box [ 57849]
  dimetal(zinc)-bound alpha+beta motif; structurally diverse
Superfamily:   RING/U-box [ 57850] (4)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Associated with multi-ubiquitination; lacks the RING-domain metal ion-binding residues
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Smart 00647; RING-associated domain


Superfamily statistics
Genomes (299) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 46,660 21,831 25
Proteins 42,974 20,371 25


Functional annotation
General category Information
Detailed category DNA replication/repair

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]