SUPERFAMILY 1.75 HMM library and genome assignments server

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RING finger domain, C3HC4 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Family:   RING finger domain, C3HC4 [ 57851] (14)


Family statistics
Genomes (473) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,236 14,724 14
Proteins 2,236 14,711 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0003445Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.09462Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.001834Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1171Moderately InformativeInherited
Phenotypic Abnormality (PA)Breast carcinoma0.0002374Highly InformativeDirect
Phenotypic Abnormality (PA)Prostate neoplasm0.0002899Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2909Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4183Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3435Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.4235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05592InformativeInherited
Mammalian Phenotype (MP)increased interleukin-2 secretion0.0005486Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0007324Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000000008661Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002224Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.2813Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.3436Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00000001054Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.004086Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.06108Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0InformativeDirect
Worm Phenotype (WP)cell stress response variant0.03101InformativeInherited
Worm Phenotype (WP)germ cell physiology variant0.09092InformativeInherited
Worm Phenotype (WP)cell ionizing radiation response variant0.01113Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.0003186Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)trichome0.00008578Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]