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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,776 44,568 8
Proteins 10,430 31,039 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5359Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.1034Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.3608Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.7566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.02962InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.522InformativeInherited
Phenotypic Abnormality (PA)Glomerulonephritis0.0001158Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000788Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.009231Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1666Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0004156Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.0628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.06631Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.5195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5215Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02822InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.156InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7519InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8579InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002427Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004003Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02778Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001368Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00133Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002204Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.003203Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004431Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005582Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04774Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0009123Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.006669Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02273Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.02322Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.03006Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1045Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1834Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2013Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2563Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3037Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.7474Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.9276Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.000008621InformativeDirect
Worm Phenotype (WP)odorant chemosensory response variant0.0002675InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0002699InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0004526InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.001278InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.003037InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.005458InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.01404InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.02281InformativeInherited
Worm Phenotype (WP)cell component localization variant0.04073InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.04441InformativeInherited
Worm Phenotype (WP)tail morphology variant0.04717InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1453InformativeInherited
Worm Phenotype (WP)cell stress response variant0.191InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3644InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000004137Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.0000005467Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.000008112Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0001977Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.09601Highly InformativeInherited
Worm Phenotype (WP)pathogen resistance increased0.1614Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.4349Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2654Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0004814InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1931Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007818InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8746Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.001072InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0.4529InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000008709Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008919Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]