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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,776 44,568 8
Proteins 10,430 31,039 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5362Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.1035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.3602Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.7565Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.02964InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.522InformativeInherited
Phenotypic Abnormality (PA)Glomerulonephritis0.0001159Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0007843Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0092Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1668Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0004123Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.06297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.06632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5215Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02827InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1566InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7518InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8572InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002428Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004028Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02778Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001335Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001305Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002178Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.003146Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004402Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005552Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04747Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0009124Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.00665Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02251Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.02299Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.02993Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1043Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1835Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2005Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2564Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3027Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.7483Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.9278Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00000852InformativeDirect
Worm Phenotype (WP)odorant chemosensory response variant0.0002657InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0002677InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0004485InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.001278InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.003017InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00544InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.014InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.02282InformativeInherited
Worm Phenotype (WP)cell component localization variant0.04064InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.04432InformativeInherited
Worm Phenotype (WP)tail morphology variant0.04718InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1453InformativeInherited
Worm Phenotype (WP)cell stress response variant0.1911InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3658InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000004128Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.000000542Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.000008114Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0001963Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.09577Highly InformativeInherited
Worm Phenotype (WP)pathogen resistance increased0.1614Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.435Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2552Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0002513InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1931Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007818InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8746Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.001072InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0.4529InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000008709Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008919Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]