SUPERFAMILY 1.75 HMM library and genome assignments server

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Leucine zipper domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Leucine zipper domain [ 57959]
Families:   Leucine zipper domain [ 57960] (16)


Superfamily statistics
Genomes (480) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,938 43,418 97
Proteins 15,887 43,270 97


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.006248Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0002507Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02622Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.06485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1072Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal liver physiology0.001328InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.1067InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.2775InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3097InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.692InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8359InformativeInherited
Mammalian Phenotype (MP)thick epidermis0.0006922Highly InformativeDirect
Mammalian Phenotype (MP)hyperkeratosis0.005412Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00177Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01823Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00004067Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8545Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000000656InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.005801InformativeInherited
Worm Phenotype (WP)RNA expression variant0.05388InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0008341Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0008565Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.02061Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0006977InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0005267Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.2199Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5608Least InformativeInherited
Fly Anatomy (FA)adult heart0.0007642InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.13Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.4502Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.02457InformativeInherited
Plant ANatomical entity (PAN)primary root0.0007654Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leucine zipper domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Leucine zipper domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]