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Leucine zipper domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Leucine zipper domain [ 57959]
Families:   Leucine zipper domain [ 57960] (16)


Superfamily statistics
Genomes (480) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,938 36,803 97
Proteins 15,887 36,673 97


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0020870.00001612Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0021110.000003147Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0031520.00008105Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0033870.0006462Least InformativeInherited
Biological Process (BP)primary metabolic process0.036771Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.0052860.2163Least InformativeInherited
Biological Process (BP)response to stimulus0.0046120Least InformativeInherited
Biological Process (BP)multi-organism process0.00075350.00000000001802Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.0017690.005908Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.01320.00004947Moderately InformativeInherited
Molecular Function (MF)binding0.011570Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000019940Moderately InformativeDirect
Molecular Function (MF)DNA binding0.0000000047380InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.000000089980InformativeDirect
Molecular Function (MF)sequence-specific DNA binding0.000000000042330.0000000000004316Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00049020Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00001612 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000003147 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00008105 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0006462 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0001041 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.2163 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.00000000001802 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000003361 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00004947 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000000000001422 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000000008562 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000001349 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000001373 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000003399 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000002585 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000003027 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00001763 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001083 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03177 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01811 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4956 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.1526 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.008279 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.005908 Moderately Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) hemopoiesis 0.000000001106 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0000002552 Informative Direct
Biological Process (BP) cell activation 0.00003697 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00008364 Informative Direct
Biological Process (BP) growth 0.0002338 Informative Direct
Biological Process (BP) cell death 0.0008666 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.4858 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9559 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.09579 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9237 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.6049 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.3452 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1157 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1846 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.6789 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) behavior 0.002835 Informative Inherited
Biological Process (BP) response to oxidative stress 0.1082 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.3792 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.8352 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9339 Informative Inherited
Biological Process (BP) defense response to other organism 0.218 Informative Inherited
Biological Process (BP) cell cycle process 0.02763 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2438 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.05847 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4811 Informative Inherited
Biological Process (BP) response to acid chemical 0.003852 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01868 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.003532 Informative Inherited
Biological Process (BP) immune effector process 0.4374 Informative Inherited
Biological Process (BP) immune response 0.7415 Informative Inherited
Biological Process (BP) circulatory system development 0.7686 Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0000000000005455 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.0000000000199 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000000003298 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.0000001019 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00001383 Highly Informative Direct
Biological Process (BP) aging 0.00003886 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.00004267 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.00006964 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0009369 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.003701 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.02111 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9951 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.0426 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.001396 Highly Informative Inherited
Biological Process (BP) response to ketone 0.434 Highly Informative Inherited
Biological Process (BP) nervous system process 0.09131 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.2299 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.4557 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.03128 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.2213 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.2067 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.01164 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.02047 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.09169 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.18 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001139 Highly Informative Inherited
Biological Process (BP) DNA replication 0.01206 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.01974 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4319 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.737 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.02981 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2862 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.2514 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.0227 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.07543 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.4253 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.1912 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) identical protein binding 0.00000002126 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.0000000000004316 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000000001306 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0000000002302 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00001569 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0002437 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.2884 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.009312 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.03094 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1291 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00003677 Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0.00000000000004454 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0000001815 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.000000000000001442Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processPlant defense0.00000000001154InformativeDirect
Biological processStress response0.00001487InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processAbscisic acid signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.00000291Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainTransmembrane0.8758Least InformativeInherited
DomainCoiled coil0.0000000006881Moderately InformativeDirect
DomainSignal-anchor0InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001433Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leucine zipper domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Leucine zipper domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]