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Tropomyosin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Family:   Tropomyosin [ 57998]


Family statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 3,786 7
Proteins 926 3,602 7


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.0285Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1013Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1246Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.347Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3901Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6352Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0004098Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.001534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.01965Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.0289Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.03372Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.03772Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.05369Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.07817Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3586Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5077Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.0005282InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.00132InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.003592InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.004511InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.006215InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.01766InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.01832InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.03787InformativeInherited
Phenotypic Abnormality (PA)Abnormal myocardium morphology0.04133InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.07697InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.08149InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1217InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.000001109Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.000004462Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0001651Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the shoulder girdle musculature0.0003539Highly InformativeDirect
Phenotypic Abnormality (PA)Waddling gait0.0003539Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0005047Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0007052Highly InformativeDirect
Phenotypic Abnormality (PA)Talipes0.001042Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the elbow0.002908Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.004548Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the scapula0.005811Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.0222Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.1936Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0001593Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.01661Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.00187Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.0616Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.8708Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001214InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0004104InformativeDirect
Worm Phenotype (WP)sluggish0.000004483Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.000921Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.4786Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6857Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7434Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1675Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.08596InformativeInherited
Zebrafish Anatomy (ZA)heart0.016Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.08369Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.391Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4965Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5672Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.8225Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05753Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1032Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1928Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.002216InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.006375InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.05474InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.09275InformativeInherited
Xenopus ANatomical entity (XAN)somite0.002371Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.8091Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.00008874Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.01816Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.000004794Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]