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SNARE fusion complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   SNARE fusion complex [ 58038]
Families:   SNARE fusion complex [ 58039] (11)


Superfamily statistics
Genomes (515) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,593 26,156 29
Proteins 10,536 23,804 29


Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00000000036860Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000013670.000000005013Least InformativeDirect
Biological Process (BP)biological regulation0.0014060.9828Least InformativeInherited
Biological Process (BP)protein complex biogenesis0.00055910.00005923Moderately InformativeDirect
Biological Process (BP)organelle organization0.33230.001746Moderately InformativeInherited
Biological Process (BP)cellular localization0.003270Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0052130.0000007446Moderately InformativeInherited
Biological Process (BP)single-organism transport11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.20720.8362Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0014020.005528Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.015590.01986Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.58090.9621Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.68691Moderately InformativeInherited
Biological Process (BP)organic substance transport0.93991Moderately InformativeInherited
Biological Process (BP)vesicle-mediated transport00InformativeDirect
Biological Process (BP)single-organism membrane organization0.00000000077450InformativeDirect
Biological Process (BP)secretion by cell0.0000000034580InformativeDirect
Biological Process (BP)protein transport0.000014610InformativeDirect
Biological Process (BP)single-organism cellular localization0.0030470.0000007588InformativeInherited
Biological Process (BP)organelle localization0.15360.01684InformativeInherited
Biological Process (BP)cellular protein complex assembly0.0087620.00008007InformativeInherited
Biological Process (BP)organelle fusion00Highly InformativeDirect
Biological Process (BP)vesicle organization00Highly InformativeDirect
Biological Process (BP)autophagy0.00000015870Highly InformativeDirect
Biological Process (BP)single-organism membrane fusion0.0000034150Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.000015920.00000002Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.000094610.00000000000001079Highly InformativeDirect
Molecular Function (MF)binding0.0050930.0000007768Least InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)protein complex0.000000000000080670Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00092220Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00030210.03031Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.46361Least InformativeInherited
Cellular Component (CC)membrane protein complex0.00000000047020Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.00000000095110Moderately InformativeDirect
Cellular Component (CC)vesicle0.00000026060Moderately InformativeDirect
Cellular Component (CC)whole membrane0.000001480.000000005721Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.0000024410.000000003483Moderately InformativeDirect
Cellular Component (CC)vacuole0.000022920Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.00034620.00000000002856Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.94251Moderately InformativeInherited
Cellular Component (CC)cytoplasmic vesicle part0.000000000075390InformativeDirect
Cellular Component (CC)vacuolar part0.000000066290InformativeDirect
Cellular Component (CC)Golgi apparatus0.0000028880InformativeDirect
Cellular Component (CC)endosome0.00054210.0000000002728InformativeDirect
Cellular Component (CC)lytic vacuole0.00000000014430.02905InformativeInherited
Cellular Component (CC)SNARE complex00Highly InformativeDirect
Cellular Component (CC)Golgi subcompartment0.000000092490.00000048Highly InformativeDirect
Cellular Component (CC)presynapse0.00000020010.00000000000004986Highly InformativeDirect
Cellular Component (CC)lysosomal membrane0.000029120.00003997Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000005013 Least Informative Direct
Biological Process (BP) biological regulation 0.9828 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein complex biogenesis 0.00005923 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00005624 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000007446 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001746 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6697 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.08084 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3277 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8362 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.005528 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01986 Moderately Informative Inherited
Biological Process (BP) cell communication 0.07602 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9621 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4586 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0000007588 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00008007 Informative Direct
Biological Process (BP) intracellular transport 0 Informative Direct
Biological Process (BP) regulation of protein localization 0.2474 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4912 Informative Inherited
Biological Process (BP) regulation of secretion 0.008695 Informative Inherited
Biological Process (BP) positive regulation of transport 0.008602 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01099 Informative Inherited
Biological Process (BP) organelle localization 0.01684 Informative Inherited
Biological Process (BP) cell activation 0.05141 Informative Inherited
Biological Process (BP) system process 0.38 Informative Inherited
Biological Process (BP) behavior 0.1439 Informative Inherited
Biological Process (BP) immune effector process 0.00116 Informative Inherited
Biological Process (BP) immune response 0.04032 Informative Inherited
Biological Process (BP) cell cycle process 0.4862 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5211 Informative Inherited
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) vesicle organization 0 Highly Informative Direct
Biological Process (BP) autophagy 0 Highly Informative Direct
Biological Process (BP) single-organism membrane fusion 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00000002 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00000000000001079 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.00001822 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000000000003306 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.000000000001269 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00000002154 Highly Informative Direct
Biological Process (BP) granulocyte activation 0.00000003276 Highly Informative Direct
Biological Process (BP) myeloid cell activation involved in immune response 0.00000008716 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000002788 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.00009482 Highly Informative Direct
Biological Process (BP) leukocyte degranulation 0.334 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.2298 Highly Informative Inherited
Biological Process (BP) nervous system process 0.4144 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.34 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.002768 Highly Informative Inherited
Molecular Function (MF) binding 0.0000007768 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.001399 Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.03031 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000000005721 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000003483 Moderately Informative Direct
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00000000002856 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00028 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.002428 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) endosome 0.0000000002728 Informative Direct
Cellular Component (CC) neuron projection 0.08391 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.03894 Informative Inherited
Cellular Component (CC) cilium 0.4774 Informative Inherited
Cellular Component (CC) plasma membrane region 1 Informative Inherited
Cellular Component (CC) lytic vacuole 0.02905 Informative Inherited
Cellular Component (CC) SNARE complex 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.00000048 Highly Informative Direct
Cellular Component (CC) presynapse 0.00000000000004986 Highly Informative Direct
Cellular Component (CC) lysosomal membrane 0.00003997 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.0003985 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.0001539 Highly Informative Direct
Cellular Component (CC) late endosome 0.00005186 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.0000009704 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.8552 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.1617 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processAutophagy0.00000000002002InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processNeurotransmitter transport0.0000000000001807Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000003866Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell projection0.03887Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentVacuole0.000002028InformativeDirect
Cellular componentCilium0.00000465InformativeDirect
Cellular componentSynaptosome0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0003749Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.000000008083Least InformativeDirect
Post-translational modificationAcetylation0.00000003513Least InformativeDirect
Post-translational modificationMethylation0.00000009879Moderately InformativeDirect
Post-translational modificationPalmitate0.00001775Moderately InformativeDirect
Post-translational modificationPrenylation0.0000000001292InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 20 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SNARE fusion complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 20 hidden Markov models representing the SNARE fusion complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]