SUPERFAMILY 1.75 HMM library and genome assignments server

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SNARE fusion complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   SNARE fusion complex [ 58038]
Families:   SNARE fusion complex [ 58039] (11)


Superfamily statistics
Genomes (515) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,593 30,487 29
Proteins 10,536 27,745 29


Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.04205Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.002844InformativeInherited
Disease Ontology (DO)endocrine organ benign neoplasm0.0000925Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.1864Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.192Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.349Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0.05759Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.08721Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.09955Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1608Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.3573Moderately InformativeInherited
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.0008487InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the synovia0.001374InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.002418InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.002448InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.002456InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007017InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.007671InformativeInherited
Phenotypic Abnormality (PA)Functional motor deficit0.01406InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.01979InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.04353InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.1818InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.1864InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.2765InformativeInherited
Phenotypic Abnormality (PA)Areflexia0.00000731Highly InformativeDirect
Phenotypic Abnormality (PA)EEG with generalized epileptiform discharges0.00002163Highly InformativeDirect
Phenotypic Abnormality (PA)Dysarthria0.0002321Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1911Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8692Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.04958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.4505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.06482InformativeInherited
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.00006391Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0001511Least InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.07294Moderately InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.4241Moderately InformativeInherited
Fly Phenotype (FP)neurophysiology defective0.0004985InformativeDirect
Fly Phenotype (FP)locomotor behavior defective0.1502InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000001027InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.000001883Moderately InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 20 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SNARE fusion complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 20 hidden Markov models representing the SNARE fusion complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]