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Apolipoprotein A-I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Apolipoprotein A-I [ 58112]
Superfamily:   Apolipoprotein A-I [ 58113]
Families:   Apolipoprotein A-I [ 58114]


Superfamily statistics
Genomes (1,450) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,299 13,624 2
Proteins 2,911 12,173 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.10750.0003973Least InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00043230.0000006921Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.00062160.000008167Moderately InformativeDirect
Biological Process (BP)response to acid chemical0.000011190.00000000006369InformativeDirect
Biological Process (BP)response to water deprivation0.000000027650Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0003973 Least Informative Direct
Biological Process (BP) biological regulation 0.925 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.0682 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9175 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2899 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6825 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.208 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.3059 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9702 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6894 Least Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0000006921 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000008167 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00005853 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0002019 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002856 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.02225 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002785 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.08158 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03331 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.713 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6199 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.07408 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.003598 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001566 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.00000000006369 Informative Direct
Biological Process (BP) lipid localization 0.000000000001268 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000006821 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0001424 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0001508 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0003523 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.005459 Informative Inherited
Biological Process (BP) response to wounding 0.04876 Informative Inherited
Biological Process (BP) generation of neurons 0.08122 Informative Inherited
Biological Process (BP) cell development 0.3835 Informative Inherited
Biological Process (BP) response to water deprivation 0 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.0000000007595 Highly Informative Direct
Biological Process (BP) regeneration 0.00000002844 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.0000000434 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0000001146 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000002494 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000005975 Highly Informative Direct
Biological Process (BP) response to axon injury 0.00003742 Highly Informative Direct
Biological Process (BP) neuron development 0.03043 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.0417 Highly Informative Inherited
Molecular Function (MF) binding 0.2807 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.004655 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.02448 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.01655 Moderately Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0003146 Informative Direct
Molecular Function (MF) phospholipid binding 0.0008228 Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.00000000003272 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.6915 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.000001235 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.06207 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0000002013 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationOxidation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Apolipoprotein A-I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Apolipoprotein A-I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]