SUPERFAMILY 1.75 HMM library and genome assignments server

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DEP domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   DEP domain [ 63483] (4)

Family statistics
Genomes (120) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 612 1,964 6
Proteins 612 1,961 6

Human Phenotype (HP)

show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00292Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1443Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.2779Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.001161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.007792Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.03295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.05753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06472Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.08366Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.3291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.3573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0005208InformativeDirect
Mammalian Phenotype (MP)abnormal heart septum morphology0.02603InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.06575InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.0000003178Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.00000568Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.00001909Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.00002049Highly InformativeDirect
Mammalian Phenotype (MP)persistent truncus arteriosis0.00009119Highly InformativeDirect
Mammalian Phenotype (MP)double outlet right ventricle0.0003106Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02659Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05171Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06152Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2345Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0005961Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0006653Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.001685Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.005423Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0082Moderately InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00001537InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00002512InformativeDirect
Worm Phenotype (WP)cell number increased0.00002734InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0001028InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0008865InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000000001421Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.00000009239Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.000000111Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.000001752Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]