SUPERFAMILY 1.75 HMM library and genome assignments server

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DEP domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   DEP domain [ 63483] (4)


Family statistics
Genomes (120) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 612 1,964 6
Proteins 612 1,961 6


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002919Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1446Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.2779Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.001161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.007792Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.03295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.05752Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.08357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.3292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.3572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0005207InformativeDirect
Mammalian Phenotype (MP)abnormal heart septum morphology0.02596InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.06577InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.0000003173Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.000005677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.00001908Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.00002047Highly InformativeDirect
Mammalian Phenotype (MP)persistent truncus arteriosis0.00009123Highly InformativeDirect
Mammalian Phenotype (MP)double outlet right ventricle0.0003106Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02667Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05177Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06178Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2352Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0005995Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0006648Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.001686Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.005433Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.008219Moderately InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00001546InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00002526InformativeDirect
Worm Phenotype (WP)cell number increased0.00002749InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0001034InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000891InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000000001429Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.00000009291Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.0000001116Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.000001762Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]