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Frizzled cysteine-rich domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Family:   Frizzled cysteine-rich domain [ 63502] (2)


Family statistics
Genomes (143) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,243 3,133 2
Proteins 1,242 3,103 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06379Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.007722Moderately InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.000163InformativeDirect
Disease Ontology (DO)myeloid leukemia0.0009999InformativeDirect
Disease Ontology (DO)multiple myeloma0.00001376Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0004267Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01033Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08279Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0001474Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.0008394Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.003338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.03391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.08853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.4176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00002433InformativeDirect
Mammalian Phenotype (MP)abnormal neural tube morphology0.003595InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.003967InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.02359InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.03013InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.00000005619Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.000001182Highly InformativeDirect
Mammalian Phenotype (MP)pigmentation phenotype0.0004009Highly InformativeDirect
Mammalian Phenotype (MP)impaired somite development0.001171Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.004582Highly InformativeInherited
Mammalian Phenotype (MP)abnormal visceral yolk sac morphology0.05284Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.4019Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.004736Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006058Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02517Least InformativeInherited
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004846Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.01159Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1444Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000002824InformativeDirect
Worm Phenotype (WP)cell number increased0.00002749InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00006063InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000891InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0876InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.9693InformativeInherited
Worm Phenotype (WP)nervous system development variant0Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000000000000939Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.00000005048Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.0000001116Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0000001892Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000001612Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.000001762Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000002541Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult external thorax0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)adult procephalic segment0InformativeDirect
Fly Anatomy (FA)adult optic lobe neuron0InformativeDirect
Fly Anatomy (FA)photoreceptor cell0InformativeDirect
Fly Anatomy (FA)ommatidium0InformativeDirect
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)sensory organ cell0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)female germline cyst0InformativeDirect
Fly Anatomy (FA)histaminergic neuron0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)epithelial cell0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect
Fly Anatomy (FA)somatic cell of ovariole0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.7754Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1065Moderately InformativeInherited
Zebrafish Anatomy (ZA)mesenchyme0.0009591Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.01101Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.01416Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.05759Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3733Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9022Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0000006083Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000001428Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.000001702Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.00225Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01915Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03545Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1865Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.4823Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9899Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0000000001584InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.000000009083InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000005611InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000006889InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001309InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00001545InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00004771InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0005332InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0007431InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.03255InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.1946InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3696InformativeInherited
Xenopus ANatomical entity (XAN)liver and biliary system0.6813InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.00000003102Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000000783Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001615Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00002191Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00008728Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.000111Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0001851Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0002047Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0002119Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0002451Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0002584Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0002596Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0002657Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.000504Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin0.003141Highly InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]