SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Tudor/PWWP/MBT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Tudor/PWWP/MBT [ 63748] (4)
Families:   Tudor domain [ 63749] (7)
  PWWP domain [ 69250] (5)
  MBT repeat [ 89299] (4)
  CPH domain [ 159021]


Superfamily statistics
Genomes (508) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,100 49,259 34
Proteins 11,507 32,384 25


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000008956Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.000000000478Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.00000000000008783Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.368e-16InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase0.0000000006493Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0.03341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1688Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1075Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1888Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.09194InformativeInherited
Phenotypic Abnormality (PA)Sandal gap0.0006555Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mouth shape0.04347Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01364Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.0291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.08218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.542Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.00009722InformativeDirect
Mammalian Phenotype (MP)abnormal fertility/fecundity0.0001029InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.1891InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.2172InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.3091InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.00007459Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0001076Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.004318InformativeInherited
Fly Phenotype (FP)size defective0.05905InformativeInherited
Fly Phenotype (FP)increased cell number0.2638Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.06338Least InformativeInherited
Zebrafish Anatomy (ZA)reproductive system0.0002692Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.003124Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.09748Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0000009202Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000008853Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.9579Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.00000000006418Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.00000001329Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.008243Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000001843InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.0000001769Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tudor/PWWP/MBT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Tudor/PWWP/MBT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]