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Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,932) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,786 75,202 6
Proteins 10,423 61,987 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.18621Least InformativeInherited
Biological Process (BP)multicellular organismal process0.65811Least InformativeInherited
Biological Process (BP)biosynthetic process0.21970.8631Least InformativeInherited
Biological Process (BP)biological regulation0.25911Least InformativeInherited
Biological Process (BP)primary metabolic process0.044041Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.011650.3328Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000035480.000002982Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.00021190.1839Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.00071270.1802Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0027920.3839Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0000087710.04313Moderately InformativeInherited
Biological Process (BP)animal organ development0.12271Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.21720.9773Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0049640.01287Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.00000068150.006447Moderately InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.000000000065550.00000000005353InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00000000013430.000008497InformativeDirect
Biological Process (BP)cation homeostasis0.00000000016830.000009557InformativeDirect
Biological Process (BP)inorganic ion homeostasis0.00000000017780.00001121InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000018580.0000001864InformativeDirect
Biological Process (BP)monosaccharide metabolic process0.0000000019130.00000003564InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.00000000052640.008525InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0023140.00103InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.000000019650.001484InformativeInherited
Biological Process (BP)post-embryonic development0.0059570.1391InformativeInherited
Biological Process (BP)animal organ morphogenesis0.0067510.3462InformativeInherited
Biological Process (BP)regulation of calcium-mediated signaling00.00000000000008895Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis0.000000000000006150.00000001226Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000000000062240.0002631Highly InformativeDirect
Biological Process (BP)post-embryonic animal morphogenesis0.000015480.001865Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0000000024090.0005217Least InformativeDirect
Molecular Function (MF)binding0.22931Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00.000000000000002411Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.000000000000088990.0000000001973Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00InformativeDirect
Molecular Function (MF)zinc ion binding0.0000000000017120.0000000004626InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8631 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3328 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000002982 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.1839 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1802 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3839 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.04313 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9773 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01287 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.006447 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8856 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3695 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4297 Moderately Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.00000000005353 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000008497 Informative Direct
Biological Process (BP) cation homeostasis 0.000009557 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.00001121 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000001864 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.00000003564 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.008525 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.00103 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.001484 Informative Inherited
Biological Process (BP) post-embryonic development 0.1391 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.3462 Informative Inherited
Biological Process (BP) response to acid chemical 0.007557 Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.00000000000008895 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00000001226 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0002631 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.001865 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0005217 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000000000000002411 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0000000001973 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.00000001551 Moderately Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0000000004626 Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Cellular Component (CC) endomembrane system 0.00005585 Moderately Informative Direct
Cellular Component (CC) cell surface 0.000002478 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processAlkaloid metabolism0.0000000000026Highly InformativeDirect
Cellular componentCytoplasmic vesicle0.0002371Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0.000000000001737Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0.00006254InformativeDirect
DomainSignal-anchor0.00009818InformativeDirect
Molecular functionMetal-binding0.0000000000005403Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.000000000004133Least InformativeDirect
Post-translational modificationLyase0.00000002489Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]