SUPERFAMILY 1.75 HMM library and genome assignments server

  Home > SCOP hierarchy > Calcium-dependent phosphotriesterase superfamily


Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]

 Superfamily statistics
Genomes (1,524) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,462 20,990 6
Proteins 8,341 17,162 6

 Functional annotation
General category Metabolism
Detailed category Other enzymes

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.73171Least InformativeInherited
Biological Process (BP)biosynthetic process0.15770.1236Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0051290.8641Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0047291Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.00031270.003088Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process5.868e-070.0005502Moderately InformativeDirect
Biological Process (BP)regulation of cell communication3.162e-050.01943Moderately InformativeInherited
Biological Process (BP)regulation of signaling6.684e-060.01875Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.00038990.1881Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.030360.004973Moderately InformativeInherited
Biological Process (BP)regulation of molecular function1.724e-070.002568Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.0011370.2674Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.000870.6028Moderately InformativeInherited
Biological Process (BP)homeostatic process0.0020120.05015Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process3.998e-082.784e-07InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process7.85e-102.868e-06InformativeDirect
Biological Process (BP)regulation of cellular catabolic process2.951e-092.047e-06InformativeDirect
Biological Process (BP)metal ion homeostasis7.721e-148.272e-08InformativeDirect
Biological Process (BP)cellular cation homeostasis3.542e-120.004735InformativeInherited
Biological Process (BP)regulation of hydrolase activity2.772e-100.007191InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.00096660.001497InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis01.178e-09Highly InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process02.055e-08Highly InformativeDirect
Biological Process (BP)regulation of purine nucleotide catabolic process01.353e-08Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process4.523e-072.521e-07Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling00Highly InformativeDirect
Molecular Function (MF)hydrolase activity1.073e-090.000179Least InformativeDirect
Molecular Function (MF)binding0.0033731Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds07.719e-07Moderately InformativeDirect
Molecular Function (MF)cation binding2.671e-143.428e-05Moderately InformativeDirect
Molecular Function (MF)transition metal ion binding0.092520.2058InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity11InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)zinc ion binding2.587e-151.065e-11Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1236 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8641 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.003088 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0005502 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0001056 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.01943 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01875 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1881 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.004973 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002568 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.2674 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.6028 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.05015 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 2.784e-07 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 2.868e-06 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.047e-06 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0005928 Informative Direct
Biological Process (BP) metal ion homeostasis 8.272e-08 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.004735 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.007191 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.001497 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1.178e-09 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.055e-08 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 1.353e-08 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.521e-07 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000179 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 7.719e-07 Moderately Informative Direct
Molecular Function (MF) lyase activity 7.711e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 3.428e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 0.2058 Informative Inherited
Molecular Function (MF) peptidase activity 0.2639 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) endopeptidase activity 4.623e-07 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 3.919e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) serine-type peptidase activity 5.099e-09 Highly Informative Direct
Molecular Function (MF) zinc ion binding 1.065e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000206 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.319 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0.000801 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0003023 Moderately Informative Direct
Cellular Component (CC) cell surface 3.537e-07 Informative Direct
Cellular Component (CC) lipid particle 3.76e-14 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases6.457e-14InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases5.063e-14Least InformativeDirect
Enzyme Commission (EC)Lyases0.006889Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9458Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0006076InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.3367Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle2.837e-05Moderately InformativeDirect
Cellular componentVacuole6.294e-08InformativeDirect
DomainSignal3.314e-07Least InformativeDirect
DomainTransmembrane0.8572Least InformativeInherited
DomainSignal-anchor9.005e-05Moderately InformativeDirect
DomainEGF-like domain2.168e-05InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase2.826e-14Least InformativeDirect
Post-translational modificationLyase7.189e-10Moderately InformativeDirect
Post-translational modificationGlycoprotein5.244e-12Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism2.072e-06Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0001461Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism5.426e-09Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism3.263e-08Moderately InformativeDirect
UniPathway (UP)alkaloid metabolism4.459e-16InformativeDirect
UniPathway (UP)terpene metabolism2.2e-11InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.