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Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,934) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,812 103,058 6
Proteins 10,449 85,483 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.09783Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.004245Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008409Moderately InformativeInherited
Disease Ontology (DO)artery disease0.008637Moderately InformativeInherited
Disease Ontology (DO)motor neuron disease0.00004418InformativeDirect
Disease Ontology (DO)coronary artery disease0.0003768InformativeDirect
Disease Ontology (DO)celiac disease0.000003859Highly InformativeDirect
Disease Ontology (DO)lateral sclerosis0.000006944Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0.00002481Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1869Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.2612Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4477Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.01898Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.06919Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1484Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.001018InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.008162InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.009443InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01892InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.03599InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1011InformativeInherited
Phenotypic Abnormality (PA)Fatigable weakness of swallowing muscles0.000000335Highly InformativeDirect
Phenotypic Abnormality (PA)Amyotrophic lateral sclerosis0.0000004875Highly InformativeDirect
Phenotypic Abnormality (PA)Xerostomia0.000001622Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0.000002069Highly InformativeDirect
Phenotypic Abnormality (PA)Agitation0.000006227Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0.00001505Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis0.00002131Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal larynx morphology0.00003172Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.0002341Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.005548Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02543Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0001681Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.01739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.0002031InformativeDirect
Mammalian Phenotype (MP)abnormal redox activity0.00001686Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000001908Least InformativeDirect
Enzyme Commission (EC)Lyases0.01293Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9884Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000003672InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.001242InformativeInherited
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.2087Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]