SUPERFAMILY 1.75 HMM library and genome assignments server

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Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,925) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,731 38,162 6
Proteins 10,375 32,361 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.88081Least InformativeInherited
Biological Process (BP)biosynthetic process0.30450.443Least InformativeInherited
Biological Process (BP)regulation of cellular process0.064111Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0086191Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0089790.14Least InformativeInherited
Biological Process (BP)regulation of biological quality0.000065360.09629Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000016540.2027Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.01245Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.000046490.02779Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0050960.7094Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000000031550.001547Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0016870.0000182Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000026090.01251Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process0.000000086950.0000002694InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.00000000000084270.000006077InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000073440.000009076InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.000000017880.0003309InformativeDirect
Biological Process (BP)cation homeostasis0.00000000034730.00004051InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.00000000031960.00002782InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.000000000014740.0000361InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.000000000035570.002234InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.0000000000000032610.00000001672Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.00000029180.0000002155Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling00.000000000000001938Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000097320.00009411Least InformativeDirect
Molecular Function (MF)binding0.24851Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00.0000009619Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000000000059950.00004569Moderately InformativeDirect
Molecular Function (MF)zinc ion binding0.0000000000001290.0000000002455InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.443 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.14 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.0000182 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.09629 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2027 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01245 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.02779 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7094 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001547 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01251 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.0002536 Informative Direct
Biological Process (BP) vitamin metabolic process 0.0000002694 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000006077 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000009076 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0003309 Informative Direct
Biological Process (BP) cation homeostasis 0.00004051 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00002782 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000361 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.002234 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.00000001672 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000002155 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.000000000000001938 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00009411 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000009619 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000002053 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00004569 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.0000000002455 Informative Direct
Molecular Function (MF) peptidase activity 0.214 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.000001498 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0001393 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0007541 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.00001206 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.9379 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0004555 Moderately Informative Direct
Cellular Component (CC) cell surface 0.0000104 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0506Least InformativeInherited
Mammalian Phenotype (MP)oxidative stress0.000009789Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000000003864Least InformativeDirect
Enzyme Commission (EC)Lyases0.006613Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9505Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.000000000002801InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0006607InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.3699Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle0.0000371Moderately InformativeDirect
Cellular componentVacuole0.0000000628InformativeDirect
DomainSignal0.00000007352Least InformativeDirect
DomainTransmembrane0.8041Least InformativeInherited
DomainEGF-like domain0.00001911InformativeDirect
DomainSignal-anchor0.00009979InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000000002202Least InformativeDirect
Post-translational modificationLyase0.0000000009091Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.0000021Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0001514Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000000008438Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.00000003475Moderately InformativeDirect
UniPathway (UP)alkaloid metabolism0.000000000000001792InformativeDirect
UniPathway (UP)terpene metabolism0.0000000000286InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]