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Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,927) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,630 38,162 6
Proteins 10,274 32,361 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.15731Least InformativeInherited
Biological Process (BP)biosynthetic process0.24780.9271Least InformativeInherited
Biological Process (BP)biological regulation0.28961Least InformativeInherited
Biological Process (BP)single-organism cellular process0.4471Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.028950.4946Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000055370.000005411Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000070010.1115Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0024320.3104Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.00086840.3089Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0084630.6857Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000003280.0169Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0020640.007437Moderately InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.00000000069310.00000001661InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000017730.0000002016InformativeDirect
Biological Process (BP)water-soluble vitamin biosynthetic process0.000000000055190.00000000006072InformativeDirect
Biological Process (BP)ion homeostasis0.0000000036780.00008475InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.0000000013290.00003278InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.0031970.001766InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.00000030450.006066InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.000000010250.0153InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.000000000000033460.0000000571Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.0000000000081460.000000000006549Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling00.000000000001097Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000000022180.0008019Least InformativeDirect
Molecular Function (MF)binding0.16961Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00.00000000000004924Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.00000000000063470.000000001146Moderately InformativeDirect
Molecular Function (MF)zinc ion binding0.000000000024110.000000004373InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.000000000000001370Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9271 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.4946 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000005411 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.1115 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3104 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3089 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6857 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.0169 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.007437 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8584 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4268 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00000001661 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000002016 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0.00000000006072 Informative Direct
Biological Process (BP) ion homeostasis 0.00008475 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00003278 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.001766 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.006066 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.0153 Informative Inherited
Biological Process (BP) response to acid chemical 0.00849 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.0000000571 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000000000006549 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.000000000001097 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0008019 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00000000000004924 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.00000001224 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000001146 Moderately Informative Direct
Molecular Function (MF) zinc ion binding 0.000000004373 Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.4563 Least Informative Inherited
Cellular Component (CC) lipid particle 0.0000000000001782 Informative Direct
Cellular Component (CC) cell surface 0.000001994 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.06557Least InformativeInherited
Disease Ontology (DO)nervous system disease0.09985Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.004014Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008251Moderately InformativeInherited
Disease Ontology (DO)artery disease0.008596Moderately InformativeInherited
Disease Ontology (DO)motor neuron disease0.00004293InformativeDirect
Disease Ontology (DO)celiac disease0.000004013Highly InformativeDirect
Disease Ontology (DO)lateral sclerosis0.000006896Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0.00002456Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0Moderately InformativeDirect
Variable expressivity0Moderately InformativeDirect
Adult onset0InformativeDirect
Rapidly progressive0Highly InformativeDirect
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Mode of Inheritance (MI)Heterogeneous0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nose0Moderately InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the tongue0InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the upper limbs0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0InformativeDirect
Phenotypic Abnormality (PA)Respiratory insufficiency0InformativeDirect
Phenotypic Abnormality (PA)Neurological speech impairment0InformativeDirect
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0InformativeDirect
Phenotypic Abnormality (PA)Abnormal pattern of respiration0InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0InformativeDirect
Phenotypic Abnormality (PA)Proximal muscle weakness0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle size0InformativeDirect
Phenotypic Abnormality (PA)Cognitive impairment0InformativeDirect
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0Highly InformativeDirect
Phenotypic Abnormality (PA)Disinhibition0Highly InformativeDirect
Phenotypic Abnormality (PA)Apathy0Highly InformativeDirect
Phenotypic Abnormality (PA)Personality changes0Highly InformativeDirect
Phenotypic Abnormality (PA)Spasticity0Highly InformativeDirect
Phenotypic Abnormality (PA)Hyporeflexia0Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0Highly InformativeDirect
Phenotypic Abnormality (PA)Tongue fasciculations0Highly InformativeDirect
Phenotypic Abnormality (PA)Dystonia0Highly InformativeDirect
Phenotypic Abnormality (PA)Brisk reflexes0Highly InformativeDirect
Phenotypic Abnormality (PA)Hoarse voice0Highly InformativeDirect
Phenotypic Abnormality (PA)Frontotemporal dementia0Highly InformativeDirect
Phenotypic Abnormality (PA)Postural tremor0Highly InformativeDirect
Phenotypic Abnormality (PA)Mutism0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lower motor neuron morphology0Highly InformativeDirect
Phenotypic Abnormality (PA)Distal muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Language impairment0Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar signs0Highly InformativeDirect
Phenotypic Abnormality (PA)Aspiration0Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated alkaline phosphatase0Highly InformativeDirect
Phenotypic Abnormality (PA)Progressive muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle cramps0Highly InformativeDirect
Phenotypic Abnormality (PA)Sensory impairment0Highly InformativeDirect
Phenotypic Abnormality (PA)Babinski sign0Highly InformativeDirect
Phenotypic Abnormality (PA)Distal amyotrophy0Highly InformativeDirect
Phenotypic Abnormality (PA)Rimmed vacuoles0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior horn cell morphology0Highly InformativeDirect
Phenotypic Abnormality (PA)Loss of ability to walk0Highly InformativeDirect
Phenotypic Abnormality (PA)Pseudobulbar paralysis0Highly InformativeDirect
Phenotypic Abnormality (PA)Amyotrophic lateral sclerosis0Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration involving the corticospinal tracts0Highly InformativeDirect
Phenotypic Abnormality (PA)Bowing of the vocal cords0Highly InformativeDirect
Phenotypic Abnormality (PA)Sleep apnea0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of peripheral nervous system electrophysiology0Highly InformativeDirect
Phenotypic Abnormality (PA)Perseveration0Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.004899Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.0273Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0001819Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.01907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.0002143InformativeDirect
Mammalian Phenotype (MP)abnormal redox activity0.00001624Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000006008Least InformativeDirect
Enzyme Commission (EC)Lyases0.01061Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9755Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.0000000000293InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0009042InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.1927Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle0.0001992Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0.0000000000013Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0.00006159InformativeDirect
DomainSignal-anchor0.00009757InformativeDirect
Molecular functionMetal-binding0.0000000000009494Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000001257Least InformativeDirect
Post-translational modificationLyase0.00000001515Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.000002237Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0001391Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.00000003485Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.00000008866Moderately InformativeDirect
UniPathway (UP)alkaloid metabolism0.00000000000001027InformativeDirect
UniPathway (UP)terpene biosynthesis0.00000000003736InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]