SUPERFAMILY 1.75 HMM library and genome assignments server


Calcium-dependent phosphotriesterase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Families:   SGL-like [ 63830] (3)
  Serum paraoxonase/arylesterase 1, PON1 [ 101895]
  All0351-like [ 159252]


Superfamily statistics
Genomes (1,916) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,611 38,162 6
Proteins 10,255 32,361 6


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.88471Least InformativeInherited
Biological Process (BP)biosynthetic process0.29720.3553Least InformativeInherited
Biological Process (BP)regulation of cellular process0.04991Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0075031Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0057950.09216Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.000010980.1534Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.008542Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.000062610.02107Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00540.6237Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000000033560.001094Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.001560.000009078Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000020180.009436Moderately InformativeInherited
Biological Process (BP)homeostatic process0.0011230.04902Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process0.000000083720.0000002367InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.0000000000013350.00000451InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000056060.000006333InformativeDirect
Biological Process (BP)cellular cation homeostasis0.000000000049910.000004319InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.000000024360.0002081InformativeDirect
Biological Process (BP)metal ion homeostasis0.000000000011830.000003414InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.000000000020810.00002611InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000000005160.002506InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.00000000000000330.00000001128Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.00000027040.0000002137Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling00Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000000005390.0001022Least InformativeDirect
Molecular Function (MF)binding0.18191Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00.0000008154Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000000000020440.00003867Moderately InformativeDirect
Molecular Function (MF)transition metal ion binding0.10060.187InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3553 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.09216 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.000009078 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.1534 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.008542 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.02107 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.6237 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001094 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.009436 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.04902 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0.0000002367 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.00000451 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000006333 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.000004319 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002081 Informative Direct
Biological Process (BP) metal ion homeostasis 0.000003414 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00002611 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.002506 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.002048 Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.00000001128 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000002137 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0001022 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000008154 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000001822 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00003867 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 0.187 Informative Inherited
Molecular Function (MF) peptidase activity 0.2133 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.000001001 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0000969 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0005609 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.8217 Least Informative Inherited
Cellular Component (CC) cell surface 0.00000639 Informative Direct
Cellular Component (CC) lipid particle 0.0000000000001739 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00446Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000006457InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04684Least InformativeInherited
Mammalian Phenotype (MP)oxidative stress0.000009189Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000000003485Least InformativeDirect
Enzyme Commission (EC)Lyases0.006499Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.9505Least InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000279InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0006627InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0.3726Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Cellular componentCytoplasmic vesicle0.00003616Moderately InformativeDirect
Cellular componentVacuole0.00000006316InformativeDirect
DomainSignal0.00000007533Least InformativeDirect
DomainTransmembrane0.8015Least InformativeInherited
DomainEGF-like domain0.00001935InformativeDirect
DomainSignal-anchor0.0001008InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000000001944Least InformativeDirect
Post-translational modificationLyase0.0000000008587Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.00000211Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0001507Least InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000000008143Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.00000003456Moderately InformativeDirect
UniPathway (UP)alkaloid metabolism0.000000000000001566InformativeDirect
UniPathway (UP)terpene metabolism0.00000000002569InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Calcium-dependent phosphotriesterase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]