SUPERFAMILY 1.75 HMM library and genome assignments server

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MoeA N-terminal region -like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   MoeA N-terminal region -like [ 63881]
Superfamily:   MoeA N-terminal region -like [ 63882]
Families:   MoeA N-terminal region -like [ 63883] (2)


Superfamily statistics
Genomes (2,211) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,492 19,514 17
Proteins 3,472 19,450 17


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.00000004812 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000004955 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000001734 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00002086 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00005252 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0003201 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.9196 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.002416 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000005563 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000000004411 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000000003564 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000002958 Moderately Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000001331 Informative Direct
Biological Process (BP) protein localization to membrane 0 Highly Informative Direct
Biological Process (BP) Mo-molybdopterin cofactor metabolic process 0.05013 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00002377Least InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.000001104Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0.00000000000158Least InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationTransferase0.00000000000001759Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005110 SSF63882 Protein matches
Abstract

Proteins in this family contain two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MoeA N-terminal region -like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the MoeA N-terminal region -like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]