SUPERFAMILY 1.75 HMM library and genome assignments server

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YjeF N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   YjeF N-terminal domain-like [ 64152]
Superfamily:   YjeF N-terminal domain-like [ 64153]
Families:   YjeF N-terminal domain-like [ 64154] (2)


Superfamily statistics
Genomes (2,322) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,820 14,631 2
Proteins 2,805 14,543 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic cyclic compound metabolic process 0.005711 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.5595 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.524 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.00759 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.002703 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.002991 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3365 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.00000334 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000006363 Moderately Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.000000001544 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000000001689 Informative Direct
Molecular Function (MF) hydrolase activity 0.2045 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.000009008 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.001035 Moderately Informative Inherited
Molecular Function (MF) racemase and epimerase activity 0.0000000008492 Informative Direct
Molecular Function (MF) nuclease activity 0.0000001919 Informative Direct
Molecular Function (MF) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo 0.000000000001669 Highly Informative Direct
Molecular Function (MF) endoribonuclease activity 0.00000000002821 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5744 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3593 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.000001794 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMitochondrion0.000000000002956Moderately InformativeDirect
DomainTransit peptide0.00008158Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0.0000000003761Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004443 SSF64153 Protein matches
Abstract The C-terminal region of yjeF from Escherichia coli shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Saccharomyces cerevisiae YKL151C and Bacillus subtilis yxkO match the yjeF C-terminal domain but lack this region. The proteins in this group are of unknown function.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a YjeF N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the YjeF N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]