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Intermediate filament protein, coiled coil region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Families:   Intermediate filament protein, coiled coil region [ 64594] (2)


Superfamily statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,439 24,274 4
Proteins 5,423 12,807 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4422Least InformativeInherited
Disease Ontology (DO)cell type cancer0.06978Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.1066Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6968Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.0561InformativeInherited
Disease Ontology (DO)respiratory system cancer0.06571InformativeInherited
Disease Ontology (DO)carcinoma0.128InformativeInherited
Disease Ontology (DO)pulmonary large cell neuroendocrine carcinoma0.000000002344Highly InformativeDirect
Disease Ontology (DO)neuroendocrine carcinoma0.0000001139Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000000002034Least InformativeDirect
Mode of Inheritance (MI)Heterogeneous0.0005265InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.0222Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3971Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3987Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.641Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7936Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8577Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.009743Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.02899Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.05138Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2502Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2793Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2903Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.6372Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7825Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8485Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.9516Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9787Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.0004101InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0007473InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nail0.001012InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.008959InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01067InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.04552InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.2138InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4634InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.793InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.8821InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.9707InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.00000000123Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the plantar skin of foot0.00000002683Highly InformativeDirect
Phenotypic Abnormality (PA)Slow-growing hair0.000001593Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000001735Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.000004934Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.000009442Highly InformativeDirect
Phenotypic Abnormality (PA)Nail dystrophy0.00002017Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00008938Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.001203Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skin of the palm0.02802Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.02859Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.3974Highly InformativeInherited
Phenotypic Abnormality (PA)Dysarthria0.5194Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of esophagus physiology0.6024Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8798Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3643Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7143Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.878Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.000007088Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.005044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.07887Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.8033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002454InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001121InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.255InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.3564InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.424InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7068InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.951InformativeInherited
Mammalian Phenotype (MP)hyperkeratosis0.000001913Highly InformativeDirect
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.000008169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.00001309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.00006436Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.0002437Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0006458Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1585Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.325Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00067Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003351Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.004406Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01702Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02186Least InformativeInherited
Worm Phenotype (WP)larval development variant0.5416Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000001194Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001754Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001796Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.01361Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1048Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.6252Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00001148InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002818InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000000000006287Highly InformativeDirect
Worm Phenotype (WP)somatic cell death variant0.000000001934Highly InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000008935Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0000001667Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001953Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0001818Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.2751Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.4135Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8967Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.9089Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000006856Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0375Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1309Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6694Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.0000009197InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000002224InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001551InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0002313InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0003045InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.007633InformativeInherited
Xenopus ANatomical entity (XAN)eye0.06164InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.00000007546Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000006039Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.00000368Highly InformativeDirect
Xenopus ANatomical entity (XAN)pelvic appendage0.0003316Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000456Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0006812Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.0009391Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal neural layer0.001296Highly InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.09673Highly InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.2686Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.04923Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.000003963Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Intermediate filament protein, coiled coil region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]