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Intermediate filament protein, coiled coil region family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Family:   Intermediate filament protein, coiled coil region [ 64594] (2)


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 797 1,949 3
Proteins 797 1,947 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.437Least InformativeInherited
Disease Ontology (DO)integumentary system disease0.000003652Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.06599Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.0938Moderately InformativeInherited
Disease Ontology (DO)lung carcinoma0.0451InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000000005308Least InformativeDirect
Mode of Inheritance (MI)Heterogeneous0.0006282InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.01807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2673Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.345Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5726Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7855Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8242Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9661Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.01889Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.03522Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2484Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2713Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.457Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.5077Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7105Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.9444Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.0000000006815InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palm0.0001695InformativeDirect
Phenotypic Abnormality (PA)Regional abnormality of skin0.0057InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.01889InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.03375InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.1956InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4998InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7568InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8695InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.8755InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.9486InformativeInherited
Phenotypic Abnormality (PA)Abnormal synaptic transmission at the neuromuscular junction1InformativeInherited
Phenotypic Abnormality (PA)Slow-growing hair0.000001323Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.000001324Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000001487Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.000004454Highly InformativeDirect
Phenotypic Abnormality (PA)Palmar hyperkeratosis0.000007247Highly InformativeDirect
Phenotypic Abnormality (PA)Nail dystrophy0.00001525Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00002453Highly InformativeDirect
Phenotypic Abnormality (PA)Squamous cell carcinoma of the skin0.000226Highly InformativeDirect
Phenotypic Abnormality (PA)Plantar hyperkeratosis0.0004955Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis0.0222Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.37Highly InformativeInherited
Phenotypic Abnormality (PA)Dysarthria0.4679Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of esophagus physiology0.5612Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3611Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7235Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.8716Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8832Least InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002017Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.004453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.04319Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1832Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001106InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.007039InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04052InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2361InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.3947InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.4248InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7074InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9202InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.000129Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0004812Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0008168Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1275Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.008016Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04012Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.04844Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000003948Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0004896Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0004996Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0009712Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.09668Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.2338Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.004956InformativeInherited
Worm Phenotype (WP)antibody staining variant0.00000000001792Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00001923Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.0000316Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0002721Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.0004629Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.2854Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.4446Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5295Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8786Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.9025Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001702Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail region0.0001917Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.04707Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1202Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6564Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.000001143InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0002087InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0003133InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0003622InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0104InformativeInherited
Xenopus ANatomical entity (XAN)eye0.07086InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system1InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.000000005478Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.0000001108Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000009231Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000003796Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0002537Highly InformativeDirect
Xenopus ANatomical entity (XAN)pelvic appendage0.0003868Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000596Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.1092Highly InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.2931Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.05049Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.000004955Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]