SUPERFAMILY 1.75 HMM library and genome assignments server

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FAD-dependent thiol oxidase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   FAD-dependent thiol oxidase [ 69000]
Families:   FAD-dependent thiol oxidase [ 69001] (2)


Superfamily statistics
Genomes (498) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,353 3,649 2
Proteins 1,349 3,629 2


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.000001872 Moderately Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.000000000008315 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002011 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000564 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.2483 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.000002792 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.001377 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0002399 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentGolgi apparatus0.000008873Moderately InformativeDirect
Cellular componentSecreted0.0001345Moderately InformativeDirect
Cellular componentMitochondrion0.000136Moderately InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainTransmembrane0.00002254Least InformativeDirect
DomainSignal0.0003529Least InformativeDirect
DomainRedox-active center0.00000004262InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006863 SSF69000 Protein matches
Abstract Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian ortholog of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane and it is thought to operate downstream of the mitochondrial ABC transporter. [PubMed11493598].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-dependent thiol oxidase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the FAD-dependent thiol oxidase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]