SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Family:   Integrin domains [ 69180] (2)


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 997 2,361 5
Proteins 487 1,168 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2441Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004246Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01108Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.12Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4724Moderately InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.0005409InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.001873InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.00317InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.003709InformativeInherited
Disease Ontology (DO)infertility0.000001774Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000006413Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0005397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.06718Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09797Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1997Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5218Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7975Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.06784Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1718Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2387Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3893Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5267Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.00005993InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01201InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.01233InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.01766InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0338InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.1588InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4306InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.527InformativeInherited
Phenotypic Abnormality (PA)Spontaneous hematomas0.000001881Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.001677Highly InformativeInherited
Phenotypic Abnormality (PA)Diarrhea0.004245Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.2164Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.000621Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0009559Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.006701Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.008438Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2426Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4365Least InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.002165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01783Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.08041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09583Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1076Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3133Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3735Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.5803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.6687Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.8197Moderately InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.0002236InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.0002777InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0007079InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0007741InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.004094InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.007543InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.0374InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.05379InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.05574InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.07252InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.1059InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.15InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.2987InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3018InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.3962InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000006703Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001234Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0002314Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD4-positive, alpha beta T cell number0.0002693Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0003057Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus basement membrane morphology0.0003633Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0006006Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular extravasation0.0007515Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.004482Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01065Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb development0.01598Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.04051Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.04683Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2641Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)cell migration variant0InformativeDirect
Worm Phenotype (WP)egg laying variant0InformativeDirect
Worm Phenotype (WP)level of protein expression variant0InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0InformativeDirect
Worm Phenotype (WP)protein metabolism variant0InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein expression reduced0Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)visible0Moderately InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)cell number defective0InformativeDirect
Fly Phenotype (FP)partially lethal0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult external thorax0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)digestive system0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0InformativeDirect
Fly Anatomy (FA)embryonic/larval neuron0InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0InformativeDirect
Fly Anatomy (FA)germline cell0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)nerve0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)midgut0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)female germline cyst0InformativeDirect
Fly Anatomy (FA)epithelial tube0InformativeDirect
Fly Anatomy (FA)germ layer derivative0Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0Highly InformativeDirect
Fly Anatomy (FA)oocyte0Highly InformativeDirect
Fly Anatomy (FA)endocuticle0Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0Highly InformativeDirect
Fly Anatomy (FA)salivary gland0Highly InformativeDirect
Fly Anatomy (FA)integumentary specialisation0Highly InformativeDirect
Fly Anatomy (FA)primary trachea0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8385Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8446Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2672InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]