SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin alpha N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Integrin alpha N-terminal domain [ 69318]
Families:   Integrin alpha N-terminal domain [ 69319]


Superfamily statistics
Genomes (1,162) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,680 57,564 2
Proteins 6,081 45,004 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000001942Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000000000008892Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)infertility0.00009761Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02296Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03093Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2067Least InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.185Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.4597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.8157Moderately InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.0008947InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.015InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.368InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.00000007076Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular extravasation0.000009091Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.00007015Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0001167Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung development0.007816Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.01174Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)reproductive system development variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.004294Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000000000305InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin alpha N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Integrin alpha N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]