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Clc chloride channel family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Clc chloride channel [ 81341]
Superfamily:   Clc chloride channel [ 81340]
Family:   Clc chloride channel [ 69912]


Family statistics
Genomes (1,692) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,887 17,453 14
Proteins 2,887 17,452 14


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1339Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3412Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.006623Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.2052Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.05738InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.6868InformativeInherited
Phenotypic Abnormality (PA)Hypokalemia0.000009924Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0001088Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.09341Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5927Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01049Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.01318Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.01379Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.07711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.00141InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2432InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.2632InformativeInherited
Mammalian Phenotype (MP)abnormal spine curvature0.001132Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)nervous system physiology variant0.0000000002178InformativeDirect
Worm Phenotype (WP)electrophysiology variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Clc chloride channel domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]