SUPERFAMILY 1.75 HMM library and genome assignments server

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Clathrin adaptor core protein family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Family:   Clathrin adaptor core protein [ 74771] (2)


Family statistics
Genomes (506) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,809 11,413 5
Proteins 3,794 11,396 5


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.7243Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Microcephaly0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of upper lip0.0005154InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.04023InformativeInherited
Phenotypic Abnormality (PA)Coarse facial features0.0002912Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004794Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.0005833InformativeDirect
Mammalian Phenotype (MP)abnormal hearing electrophysiology0.000278Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001517Least InformativeInherited
Worm Phenotype (WP)cell development variant0.02036Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.00000423Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00006219Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0006873Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001328Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.003025Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.07314Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.1164Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.3846Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4251Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.4866Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.5166Moderately InformativeInherited
Worm Phenotype (WP)diplotene progression during oogenesis variant0.00004795InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000933InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0001637InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.000166InformativeDirect
Worm Phenotype (WP)body length variant0.0002229InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.000232InformativeDirect
Worm Phenotype (WP)gonad development variant0.0003616InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0007381InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.000005068Highly InformativeDirect
Worm Phenotype (WP)diplotene region organization variant0.000008895Highly InformativeDirect
Worm Phenotype (WP)rachis narrow0.00003605Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.00005287Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)epithelium0.01446Moderately InformativeInherited
Fly Anatomy (FA)epithelial tube0.0007275InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]