SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Clathrin adaptor core protein family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Family:   Clathrin adaptor core protein [ 74771] (2)


Family statistics
Genomes (506) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,809 11,413 5
Proteins 3,794 11,396 5


Human Phenotype (HP)

(
show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.03491Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0.1251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal appendicular skeleton morphology0.3581Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4465Moderately InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of eye movement0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of upper lip0.0006968InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.0007965InformativeDirect
Phenotypic Abnormality (PA)Functional motor deficit0.005616InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the central nervous system0.009197InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.009341InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.3117InformativeInherited
Phenotypic Abnormality (PA)Cerebral atrophy0.0001369Highly InformativeDirect
Phenotypic Abnormality (PA)Coarse facial features0.0002869Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar atrophy0.0004542Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the corpus callosum0.0006777Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.1321Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004784Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.0005805InformativeDirect
Mammalian Phenotype (MP)abnormal auditory brainstem response0.0002454Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02113Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.000004326Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00006173Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0006792Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00137Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.003056Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.0734Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.1131Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.3827Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.431Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.4909Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.5002Moderately InformativeInherited
Worm Phenotype (WP)diplotene progression during oogenesis variant0.00004838InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00009422InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.0001653InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0001653InformativeDirect
Worm Phenotype (WP)body length variant0.0002322InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0002434InformativeDirect
Worm Phenotype (WP)body width variant0.0003225InformativeDirect
Worm Phenotype (WP)gonad development variant0.0003569InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0007384InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.000004934Highly InformativeDirect
Worm Phenotype (WP)diplotene region organization variant0.000008973Highly InformativeDirect
Worm Phenotype (WP)rachis narrow0.00003635Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0000523Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]